Human Papillomavirus (HPV)

  • Amelia B. ThompsonEmail author
  • Lisa C. Flowers


Human papillomavirus (HPV) is a double stranded DNA (dsDNA) virus that often causes an asymptomatic infection and clears spontaneously. However, HPV infection may result in genital warts, dysplasia, and squamous cell carcinoma of the head, neck and genitalia. Genital HPV is the most common sexually transmitted infection (STI) in the United States. HPV infection may lead to significant morbidity for both immunocompetent and immunocompromised persons. Immunocompromised persons, including those with human immunodeficiency virus (HIV) infection, are more likely to develop persistent HPV infection and its associated complications. All adolescents and young adults should get the HPV vaccine, ideally prior to initiation of sexual intercourse, in order to prevent infection and the subsequent potential for progression to malignancy.


Human papillomavirus Genital warts Recurrent respiratory papillomatosis Dysplasia Cancer 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Duke University School of MedicineDurhamUSA
  2. 2.Emory University School of MedicineAtlantaUSA

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