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Alterations in Thyroid Function Testing with Aging

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Advances in Human Factors and Ergonomics in Healthcare and Medical Devices (AHFE 2019)

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 957))

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Abstract

In the present study, we investigated if there are any diurnal variations in serum thyroid stimulating hormone (TSH) levels in normal subjects and any alterations in serum TSH, free thyroxine (fT4), and free triiodothyronine (fT3) levels with aging. Our results showed the presence of a circadian rhythm in serum TSH levels in normal subjects (n = 11; 5 males, 6 females; age range 19–46) with no significant changes in fT3 and fT4, indicating that the regulation of TSH is central rather than peripheral. In addition, we examined samples from 1,571 euthyroid outpatients (513 males, 1,058 females; age range 10–90) over a 6-month period. Serum TSH levels in age groups 50–59, 60–69, 70–79, and 80–89 were found to be progressively higher than those in the age group 10–19 with no significant differences between male and female populations. These findings suggest the presence of an alteration in TSH secretion with aging.

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Authors and Affiliations

  1. Saskatoon Health Region, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK, S7N 0W8, Canada

    Jawahar (Jay) Kalra

  2. Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada

    Jawahar (Jay) Kalra & Zoher Rafid-Hamed

  3. Northern Medical Program, Faculty of Medicine, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada

    Patrick Seitzinger

Authors
  1. Jawahar (Jay) Kalra
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  2. Zoher Rafid-Hamed
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  3. Patrick Seitzinger
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Correspondence to Jawahar (Jay) Kalra .

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Editors and Affiliations

  1. Veterans Affairs - Center for Applied Systems Engineering, Indianapolis, IN, USA

    Nancy J. Lightner

  2. Department of Pathology, College of Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada

    Jay Kalra

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Kalra, J.(., Rafid-Hamed, Z., Seitzinger, P. (2020). Alterations in Thyroid Function Testing with Aging. In: Lightner, N., Kalra, J. (eds) Advances in Human Factors and Ergonomics in Healthcare and Medical Devices. AHFE 2019. Advances in Intelligent Systems and Computing, vol 957. Springer, Cham. https://doi.org/10.1007/978-3-030-20451-8_26

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  • DOI: https://doi.org/10.1007/978-3-030-20451-8_26

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-20450-1

  • Online ISBN: 978-3-030-20451-8

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