Abstract
Fiber tractography in baby diffusion MRI is challenging due to the low and spatially-varying diffusion anisotropy, causing most tractography algorithms to yield streamlines that fall short of reaching the cortex. In this paper, we introduce a method called asymmetry spectrum imaging (ASI) to improve the estimation of white matter pathways in the baby brain by (i) incorporating an asymmetric fiber orientation model to resolve subvoxel fiber configurations such as fanning and bending, and (ii) explicitly modeling the range (or spectrum) of typical diffusion length scales in the developing brain. We validated ASI using in-vivo baby diffusion MRI data from the Baby Connectome Project (BCP), demonstrating that ASI can characterize complex subvoxel fiber configurations and accurately estimate the fiber orientation distribution function in spite of changes in diffusion patterns. This, in turn, results in significantly better diffusion tractography in the baby brain.
This work was supported in part by NIH grants (NS093842, EB022880, MH104324 and 1U01MH110274), a research grant from Nestec Ltd., and the efforts of the UNC/UMN Baby Connectome Project Consortium.
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Wu, Y., Lin, W., Shen, D., Yap, PT., and the UNC/UMN Baby Connectome Project Consortium. (2019). Asymmetry Spectrum Imaging for Baby Diffusion Tractography. In: Chung, A., Gee, J., Yushkevich, P., Bao, S. (eds) Information Processing in Medical Imaging. IPMI 2019. Lecture Notes in Computer Science(), vol 11492. Springer, Cham. https://doi.org/10.1007/978-3-030-20351-1_24
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