Abstract
Prosopis cineraria (L.) Druce (Family Leguminosae, subfamily Mimosoideae) has a number of uses in ethnomedicine. P. cineraria has social, ethnological, traditional and remedial effects on the lives of people. P. cineraria is an important herbal plant as mentioned in the ancient literature. It is used traditionally for treatment of various ailments like leprosy, dysentery, asthma, leukoderma, dyspepsia and earache. The objective is to review the phytochemicals and the bio potential of the plant. This paper includes an overview on the studies of different herbal extracts, metabolites and major classes of metabolites which are pharmacologically active, like alkaloids and flavonoids, which have anti-tumor, antioxidant, anti-diabetic, anti-nociceptive, estrogenic and antimicrobial activity. A comprehensive literature survey was performed on the phytochemicals present in the different parts of the plant P. cineraria and their pharmacological properties with chemical structures. This review was prepared with thorough advanced search by using key words P. cineraria (L.) Druce in Google, Google Scholar, PubMed, SciFinder, Scopus and ProQuest as well as from English language scientific journals, magazines and books. The phytochemicals discussed in the present review could be promising candidates to be utilized as bioactive compounds for direct use as drug or herbal extracts as botanical drugs.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Pasiecznik NM, Felker P, Harris PJ, Harsh L, Cruz G, Tewari J et al (2001) The ‘Prosopis juliflora’ -‘Prosopis pallida’ complex: a monograph. HDRA Publishing, Coventry, UK, p 172
Khatri A, Rathore A, Patil U (2010) Prosopis cineraria (L.) Druce: a boon plant of desert-an overview. Int J Biomed Adv Res 1:141–149
Gallacher DJ, Hill JP (2005) Status of Prosopis cineraria (Ghaf) tree clusters in the Dubai Desert Conservation Reserve. Tibullus 15:3–9
Pasiecznik N, Harris P, Smith S (2004) Identifying tropical Prosopis species: a field guide. HDRA Publishing, Coventry, UK, p 29
Chikuni M, Dudley C, Sambo E (2005) Prosopis glandulosa Torrey (leguminosae-Mimosoidae) at Swang’oma, Lake Chilwa plain: a blessing in disguise? Malawi J Sci Technol 7:10–16
Geesing D, Al-Khawlani M, Abba ML (2004) Management of introduced Prosopis species: can economic exploitation control an invasive species? Unasylva 55:36–5544
Arshad M, Ashraf M, Arif N (2006) Morphological variability of Prosopis cineraria (L.) Druce, from the Cholistan desert, Pakistan. Genet Resour Crop Evol 53:89–96
Shackleton RT, Le Maitre DC, Pasiecznik NM, Richardson DM (2014) Prosopis: a global assessment of the biogeography, benefits, impacts and management of one of the world’s worst woody invasive plant taxa. AoB Plants 6:1–18
Jongbloed MVD, Feulner GR, Böer B, Western AR, Environmental Research and Wildlife Development Agency (2003) The comprehensive guide to the wild flowers of the United Arab Emirates. Environmental Research and Wildlife Development Agency (ERWDA), Abu Dhabi, pp 1–574
Gallacher D, El-Keblawy A (2016) Macromorphology and recruitment of Prosopis cineraria in the United Arab Emirates. Ecol Environ Conserv 22:499–504
Abdel Bari E, Fahmy G, Al Thani N, Al Thani R, Abdel-Dayem M (2007) The Ghaf tree, Prosopis cineraria in Qatar. Environmental Studies Centre and National Council for Culture, Arts and Heritage, Doha, p 163
Böer B (1997) An introduction to the climate of the United Arab Emirates. J Arid Environ 35:3–16
Lemons J, Victor R, Schaffer D (2003) Conserving biodiversity in arid regions: best practices in developing nations. Springer Science & Business Media, The Netherlands
Orwa C, Mutua A, Kindt R, Jamadars R, Simons A (2009) Agroforestry database: a tree species reference and selection guide version 4.0. World Agroforestry Centre ICRAF, Nairobi, Kenya
Philp M (2013) UAE groups help to save Ghaf trees on UN ‘Combat Desertification Day’. 7 DAYS in Dubai, Al Sidra Media. Retrieved 11 Sept 2013
Alam H, Khattak JZ, Ppoyil SB, Kurup SS, Ksiksi TS (2017) Landscaping with native plants in the UAE: a review. Emirates J Food Agric 6:729–74117
Pareek AK, Garg S, Kuma M (2015) Prosopis cineraria: a gift of nature for pharmacy. Int J Pharma Sci Res 6:958–964
Chaudhry P (2011) Prosopis cineraria (L) Druce a lifeline tree species of the Thar Desert in danger. Biodivers Ecol Sci 1:289–293
Mann H, Shankar Narayan K (1980) The role of Prosopis cineraria in an agropastoral system in Western Rajasthan. Africa International Livestock Centre for Africa, Addis Ababa, pp 437–442
Panwar D, Pareek K, Bharti CS (2014) Unripe pods of Prosopis cineraria used as a vegetable (Sangri) in Shekhawati region. Int J Sci Eng Res 5:2014
Rogers KE (2000) The magnificent mesquite, 1st edn. University of Texas Press, USA. ISBN-10:0292771
Sharma D, Singla YP (2013) Evaluation of antihyperglycemic and anti-hyperlipidemic activity of Prosopis cineraria (Linn.) in Wistar rats. J Sci Innov Res 2:751–758
Ghazanfar SA, Al-Al-Sabahi AM (1993) Medicinal plants of Northern and Central Oman (Arabia). Econ Bot 47:89–98
Altemimi A, Lakhssassi N, Baharlouei A, Watson DG, Lightfoot DA (2017) Phytochemicals: extraction, isolation, and identification of bioactive compounds from plant extracts. Plants (Basel) 6:42
Altemimi A, Lightfoot DA, Kinsel M, Watson DG (2015) Employing response surface methodology for the optimization of ultrasound assisted extraction of lutein and β-carotene from spinach. Molecules 20:6611–6625
Liu Y, Singh D, Nair MG (2012) Pods of Khejri (Prosopis cineraria) consumed as a vegetable showed functional food properties. J Funct Foods 4:116–121
Corrales M, Toepfl S, Butz P, Knorr D, Tauscher B (2008) Extraction of anthocyanins from grape by-products assisted by ultrasonic, high hydrostatic pressure or pulsed electric fields: a comparison. Innov Food Sci Emerg Technol 9:85–91
Burkart A (1976) A monograph of the genus Prosopis (Leguminosae subfam. Mimosoideae). J Arnold Arboretum 57:450–525
Gallacher D, Hill J (2005) Status of Prosopis cineraria (ghaf) tree clusters in the Dubai Desert Conservation Reserve. Tribulus 15:3–9
Shiferaw H, Teketay D, Nemomissa S, Assefa F (2004) Some biological characteristics that foster the invasion of Prosopis juliflora (Sw.) DC. at Middle Awash Rift Valley Area, northeastern Ethiopia. J Arid Environ 58:135–154
Felker P, Cannell G, Osborn J, Clark P, Nash P (1983) Effects of irrigation on biomass production of 32 Prosopis (mesquite) accessions. Exp Agric 19:187–198
Mandaville JP (1990) Flora of eastern Saudi Arabia. Kegan Paul International London and New York jointly with the National Commission for Wildlife Conservation and Development, Riyadh. ISBN 07103-0371-8
Robertson S, Narayanan N, Raj Kapoor B (2011) Antitumor activity of Prosopis cineraria (L.) Druce against Ehrlich ascites carcinoma-induced mice. Nat Prod Res 25:857–862
Maideen N, Velayutham R, Manavalan G (2011) Protective activity of Prosopis cineraria against N-nitrosodiethylamine induced liver tumors in accordance to mitochondrial lipid peroxidation, mitochondrial antioxidant and liver weight. Cont J Pharm Sci 5:1e6
Satish PV, Somaiah K, Brahmam P, Rekha NS, Sunita K (2015) Antimalarial activity of Prosopis cineraria (L) Druce against chloroquine sensitive Plasmodium falciparum 3D7 strain. Eur J Pharm Med Res 2:295–303
Ramakrishnan G, Raghavendran HR, Vinodhkumar R, Devaki T (2006) Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chem Biol Interact 161:104–114
Jinu U, Gomathi M, Saiqa I, Geetha N, Benelli G, Venkatachalam P (2017) Green engineered biomolecule-capped silver and copper nanohybrids using Prosopis cineraria leaf extract: enhanced antibacterial activity against microbial pathogens of public health relevance and cytotoxicity on human breast cancer cells (MCF-7). Microb Pathog 105:86–95
Sumathi S, Dharani B, Sivaprabha J, Raj KS, Padma P (2013) Cell death induced by methanolic extract of Prosopis cineraria leaves in MCF-7 breast cancer cell line. Int J Pharmacol Sci Invent 2:21–26
Maideen NM, Velayutham R, Manavalan G (2012) Protective effect of Prosopis cineraria against N-nitrosodiethylamine induced liver tumor by modulating membrane bound enzymes and glycoproteins. Adv Pharm Bull 2:179
Dharani B, Sumathi S, Sivaprabha J, Padma P (2011) In vitro antioxidant potential of Prosopis cineraria leaves. J Nat Prod Plant Resour 1:26–32
Mohammad IS, Haji Muhammad Shoaib Khan NA, Rasool F (2013) Biological potential and phytochemical evaluation of Prosopis cineraria. World Appl Sci J 27:1489–1494
Bangaruswamy D, Jambunathan S, Padma PR, Sundaravadivelu S (2015) Prosopis cineraria leaf extract protect H2O2 induced oxidative stress-induced cell death in Saccharomyces cerevisiae. Asian J Pharm Clin Res 8:311–315
Karim AA, Azlan A (2012) Fruit pod extracts as a source of nutraceuticals and pharmaceuticals. Molecules 17:11931–11946
Sharma N, Garg V, Paul A (2010) Antihyperglycemic, antihyperlipidemic and antioxidative potential of Prosopis cineraria bark. Indian J Clin Biochem 25:193–200
Velmurugan V, Arunachalam G, Ravichandran V (2010) Antibacterial activity of stem bark of Prosopis cineraria (Linn.) Druce. Arch App Sci Res 2:147–150
Salar RK, Dhall A (2010) Antimicrobial and free radical scavenging activity of extracts of some Indian medicinal plants. J Med Plants Res 4:2313–2320
Preeti K, Avatar SR, Mala A (2015) Pharmacology, phytochemistry and therapeutic application of Prosopis cineraria Linn: a review. J Plant Sci 3:33–39
Robertson S, Narayanan N (2009) Pharmacognostical and antimicrobial studies of the stem barks of Prosopis cineraria (L) Druce. Res J Pharmacognosy Phytochem 1:227–231
Kapoor BB, Bansal R (2013) Antimicrobial screening of some medicinal tree species of Nagaur District of Rajasthan. Int J Herbal Med 1:10–11
George M, Joseph L, Sharma A (2012) Antidepressant and skeletal muscle relaxant effects of the aqueous extract of the Prosopis cineraria. Braz J Pharm Sci 48:577–581
Manikandar RV, Rajesh V, Kumar RS, Perumal P, Raj CD (2009) Analgesic and anti-pyretic activity of stem bark of Prosopis cineraria (Linn) Druce. J Pharm Res 2:660–662
Kumar A, Yadav SK, Singh S, Pandeya S (2011) Analgesic activity of ethanolic extract of roots of Prosopis cineraria (L.) Druce. J App Pharm Sci 1:158
Gupta A, Verma S, Gupta AK, Jangra M, Pratap R (2015) Evaluation of Prosopis cineraria (Linn.) Druce leaves for wound healing activity in rats. Ann Pharm Res 3:70–74
Asija S, Jeyabalan G, Ahuja A, Asija R (2015) Formulation and evaluation of Prosopis cineraria (Linn.) Druce phospholipid complex. Asian J Chem Pharm Res 3301–3305
Purohit A, Ram H (2012) Hypolipidemic and antiatherosclerotic effects of Prosopis cineraria bark extract in experimentally induced hyperlipidemic rabbits. Asian J Pharm Clin Res 5:106–109
Jain PG, Surana SJ (2015) Hypolipidemic activity of Prosopis cineraria L (Druce) fruit extract and molecular modeling study with farnesoid X receptor (FXR). Trop J Pharm Res 14:1621–1628
Velmurugan V, Arunachalam G, Ravichandran V (2012) Anticonvulsant activity of methanolic extract of Prosopis cineraria (Linn) Druce stem barks. Int J PharmTech Res 4:89–92
Janbaz KH, Haider S, Imran I, Zia-ul-Haq M, De Martino L, De Feo V (2012) Pharmacological evaluation of Prosopis cineraria (L.) Druce in gastrointestinal, respiratory, and vascular disorders. Evid Based Complement Altern Med 212:7–12
Bithu BS, Reddy NR, Prasad SK, Sairam K, Hemalatha S (2012) Prosopis cineraria: a potential nootropic agent. Pharm Biol 50:1241
Gupta A, Sharma G, Pandey S, Verma B, Pal V, Agrawal SS (2014) Prosopis cineraria and its various therapeutic effects with special reference to diabetes: a novel approach. Int J Pharm Sci Rev Res 27:328–333
Marquez SR, Aguirre FG, Alcantara M, Diaz EG, Gutierrez MM, Silva MA, Lopez G, Romero C, Chemineau P, Keller M, Delgadillo JA (2012) Mesquite pod extract modifies the reproductive physiology and behavior of the female rat. Horm Behav 61:549–558
Velmurugan V, Arunachalam G, Ravichandran V (2011) Anthelmintic potential of Prosopis cineraria (Linn.) Druce stem barks. Asian J Plant Sci Res 1:88–91
Sivaraman T, Rajesh SS, Elango V (2013) In vivo studies on detoxifying actions of aqueous bark extract of Prosopis cineraria against crude venom from Indian cobra (Naja naja). Bangladesh J Pharmacol 8:395–400
Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461–477
Prabha DS, Dahms HU, Malliga P (2014) Pharmacological potentials of phenolic compounds from Prosopis spp.-a. J Coast Life Med 2:918–924
Duke JA (2014) Dr. Duke’s phytochemical and ethnobotanical databases. National Government Publication, Fulton, USA
Robertson S, Narayanan N (2014) Isolation and characterization of secondary metabolite from Prosopis cineraria (L.) Druce for anticancer activity. World J Pharm Res 3:876–884
López-Lázaro M (2009) Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem 9:31–59
Leakey R (1980) Biology and potential of Prosopis species in arid environments, with particular reference to P. cineraria. J Arid Environ 3:9–24
Rahman AA, Samoylenko V, Jacob MR, Sahu R, Jain SK, Khan SI, Tekwani BL, Muhammad I (2011) Antiparasitic and antimicrobial indolizidines from the leaves of Prosopis glandulosa var. glandulosa. Planta Med 77:1639–1643
Ferguson LR, Zhu S-T, Harris PJ (2005) Antioxidant and antigenotoxic effects of plant cell wall hydroxycinnamic acids in cultured HT-29 cells. MN Food Res 49:585–593
Khan R, Zakir M, Afaq SH, Latif A, Khan AU (2010) Activity of solvent extracts of Prosopis spicigera, Zingiber officinale and Trachyspermum ammi against multidrug resistant bacterial and fungal strains. J Infect Dev Countries 4:292–300
Garg A, Mittal SK (2013) Review on Prosopis cineraria: a potential herb of Thar desert. Drug Invent Today 5:60–65
Malik S, Mann S, Gupta D, Gupta RK (2013) Nutraceutical properties of Prosopis cineraria (L.) Druce pods. J Pharmacognosy Phytochem 2:66–73
Rani B, Singh U, Sharma R, Gupta A, Dhawan NG, Sharma AK et al (2013) Prosopis cineraria (L) Druce: a desert tree to brace livelihood in Rajasthan. Asian J Pharm Res Health Care 5:58–64
Bhardwaj DK, Gupta AK, Jain RK, Sharma GC (1981) Chemical examination of Prosopis spicigera seeds. J Nat Prod 44:656–659
Ukani M, Limbani N, Mehta N (2000) A review on the Ayurvedic herb Prosopis cineraria (L) Druce. Anc Sci Life 20:58
Claude B, Paule S (1979) The manual of natural living, 1st edn. Biddles Limited Guildford, Surrey, UK, p 98
Tapia A, Feresin GE, Bustos D (2000) Biologically active alkaloids and a free radical scavenger from Prosopis species. J Ethnopharmacol 71:241–246
Mason TL, Wasserman BP (1987) Inactivation of red beet beta glucan synthase by native and oxidized phenolic compounds. Phytochem 26:2197–2202
Chandrakala S, Mallikarjuna K, Reddy C (2013) In vitro pharmacological investigations of Biophytum sensitivum callus extract: lack of potent activities. J Pharm Negat Results 4:60–62
Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047–1053
Edeoga HO, Okwu DE, Mbaebie BO (2005) Phytochemical constituents of some Nigerian medicinal plants. Afr J Biotechnol 4:685–688
Pal D, Chancha MK (2015) Prosopis cineraria (L.) Druce: a boon plant of desert—an overview. Int J Sci Eng Res 6:112–114
Bhardwaj DK, Bisht MS, Mehta CK, Sharma GC (1979) Flavonoids of Prosopis spicigera flowers. Phytochem 18:355–366
Bhardwaj DK, Jain RK, Sharma GC, Mehta CK (1978) Prosogerin-C, a new flavone from Prosopis spicigera seeds. Indian J Chem B16:1133–1134
Bhardwaj DK, Bisht MS, Jain RK (1980) Prosogerin-D, a new flavone of Prosopis spicigera seeds. Phytochem 19:1269–1270
Aneela S, Dey A, De S (2014) GC-MS analysis of methanolic extract of Prosopis spicigera. Int J Phytopharmacol 5:168–171
Khan S, Riaz N, Afza N, Nelofar A, Malik A, Ahmed E et al (2006) Studies on the chemical constituents of Prosopis cineraria. J Chem Soc Pakistan 28:619–622
Singh S, Naresh V, Sharma SK (2013) Pharmacognostic studies on the leaves of Prosopis cineraria (L) Druce growing in South Haryana, India. J Pharmacognosy Phytochem 2:320–325
Gangal S, Sharma S, Rauf A (2009) Fatty acid composition of Prosopis cineraria seeds. Chem Nat Compd 45:705
Jewers K, Nagler MJ, Zirvi KA, Amir F (1976) Lipids, sterols, and a piperidine alkaloid from Prosopis spicigera leaves. Phytochem 15:238–240
Soni LK, Dobhal S, Parasher P, Dobhal MP (2018) Phytochemicals from Prosopis sp. Int J Environ Sci Technol 4:9–32
Acknowledgements
We thank Ajman University for support and financial provision.
Funding
This work was supported by grants from Ajman University, Ajman, United Arab Emirates (Project ID No: Ref. # 2017-A-PH-02).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this paper
Cite this paper
Islam, M.W., Bloukh, S.H., Edis, Z., Bhandare, R.R. (2019). Emerging Phytochemicals and Bioactive Compounds from a Desert Plant Prosopis cineraria (L.) Druce and Future Prospects. In: Ramasami, P., Gupta Bhowon, M., Jhaumeer Laulloo, S., Li Kam Wah, H. (eds) Chemistry for a Clean and Healthy Planet. ICPAC 2018. Springer, Cham. https://doi.org/10.1007/978-3-030-20283-5_2
Download citation
DOI: https://doi.org/10.1007/978-3-030-20283-5_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-20282-8
Online ISBN: 978-3-030-20283-5
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)