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Management of Local-Regional Anal Cancer Recurrence

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Abstract

Anal cancer, a rare gastrointestinal disease, accounts for 1–2.5% of gastrointestinal cancers. Primary treatment is chemoradiation. Ten to 30% of patients experience local relapse, and salvage surgery is a second line of treatment for these patients. Wide local excision, abdominoperineal resection, pelvic exenteration with or without sacrectomy, and inguinal node dissection are all surgical options. In this chapter, we review the management and treatment options for patients who are initially treated with chemoradiation and experience local-regional recurrence of the disease.

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Abbreviations

5-FU:

5-Fluorouracil

APR:

Abdominoperineal resection

HAART:

Highly active antiretroviral therapy

HIV:

Human immunodeficiency virus

HPV:

Human papillomavirus

MRI:

Magnetic resonance imaging

SCC:

Squamous cell carcinoma

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Authors and Affiliations

  1. Department of Surgical Oncology, Fox Chase Cancer Center, Temple University, Philadelphia, PA, USA

    Shilpa S. Murthy & Elin R. Sigurdson

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  1. Shilpa S. Murthy
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  2. Elin R. Sigurdson
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Editors and Affiliations

  1. Department of Radiation Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Jeffrey Meyer

  2. Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, TN, USA

    Lisa Kachnic

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Murthy, S.S., Sigurdson, E.R. (2019). Management of Local-Regional Anal Cancer Recurrence. In: Meyer, J., Kachnic, L. (eds) Anal Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-20253-8_6

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  • DOI: https://doi.org/10.1007/978-3-030-20253-8_6

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