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Introduction

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Abstract

Atherosclerosis is the progressive buildup of plaque inside arteries and the leading cause of vascular disease worldwide. Despite decades of research, the pathomechanisms of disease development are still not known. Contrary to popular belief, atherosclerosis is not a generalized disease but rather shows significant site specificity with some sites preferentially spared from disease. This chapter is a brief introduction to some of the misconceptions and outstanding questions in the field of atherosclerosis research.

Keywords

Atherosclerosis Site specificity of disease Pathophysiology Cardiovascular disease Microvasculature 

References

  1. 1.
    Defense USD. DoD News Briefing–Secretary Rumsfeld and Gen. Myers. 2002. http://archive.defense.gov/Transcripts/Transcript.aspx?TranscriptID=2636. Accessed 20 Sept 2018.
  2. 2.
    Marchand F. Über Arteriosklerose. Verhandlungen des Kongresses für Inn Medizin 21 Kongress Leipzig; 1904. p. 23–59.Google Scholar
  3. 3.
    WHO. Projections of mortality and causes of death, 2015 and 2030. 2012. http://www.who.int/healthinfo/global_burden_disease/projections/en/.
  4. 4.
    Ophüls W. Arteriosclerosis cardiovascular disease: their relation to infectious diseases. 1st ed. California: Standford University Press; 1921.Google Scholar
  5. 5.
    Winternitz MC, Thomas RMM, LeCompte P. The biology of arteriosclerosis. Springfield, IL: Charles C Thomas; 1938.CrossRefGoogle Scholar
  6. 6.
    Creech O. A surgeon’s view of atherosclerosis. Am Heart J. 1957;54:641–2.CrossRefGoogle Scholar
  7. 7.
    French JE. Atherosclerosis in relation to the structure and function of the arterial intima, with special reference to th endothelium. Int Rev Exp Pathol. 1966;5:253–353.PubMedGoogle Scholar
  8. 8.
    Hauss WH, Bauch HJ, Schulte H. Adrenaline and noradrenaline as possible chemical mediators in the pathogenesis of arteriosclerosis. Ann NY Acad Sci. 1990;598:91–101.CrossRefGoogle Scholar
  9. 9.
    Nakashima Y, Wight TN, Sueishi K. Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans. Cardiovasc Res. 2008;79:14–23.  https://doi.org/10.1093/cvr/cvn099.CrossRefGoogle Scholar
  10. 10.
    National Heart, Lung and BI Atherosclerosis. https://www.nhlbi.nih.gov/health/health-topics/topics/atherosclerosis/causes. Accessed 18 Sept 2018.
  11. 11.
    Hansen T, Wikström J, Johansson LO, et al. The prevalence and quantification of atherosclerosis in an elderly population assessed by whole-body magnetic resonance angiography. Arterioscler Thromb Vasc Biol. 2007;27:649–54.  https://doi.org/10.1161/01.ATV.0000255310.47940.3b.CrossRefPubMedGoogle Scholar
  12. 12.
    Burke AP, Farb A, Malcom GT, et al. Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women. Circulation. 1998;97:2110–6.CrossRefGoogle Scholar
  13. 13.
    Anitschow NN, Chalatow S. Ueber den Gehalt normaler und atheromatoser Aorten an Cholesterol und Cholesterinester. Zentrbl Allg Pathol Pathol Anat. 1913;24:1–9.Google Scholar
  14. 14.
    Stehbens WE. Coronary heart disease, hypercholesterolemia, and atherosclerosis I. False premises. Exp Mol Pathol. 2001;70:103–19.  https://doi.org/10.1006/exmp.2000.2340.CrossRefPubMedGoogle Scholar
  15. 15.
    Stehbens WE. Coronary heart disease, hypercholesterolemia, and atherosclerosis II. Misrepresented data. Exp Mol Pathol. 2001;70:120–39.  https://doi.org/10.1006/exmp.2000.2339.CrossRefPubMedGoogle Scholar
  16. 16.
    Thayer W, Brush C. The relation of acute infections and arteriosclerosis. JAMA. 1904;43:583–4.Google Scholar
  17. 17.
    Thayer W. On the late effects of typhoid fever on the heart and vessels. Am J Med Sci. 1904;77:391–422.CrossRefGoogle Scholar
  18. 18.
    Gilbert L. Artérites infectieuses expérimentales. Compt rend Soc biol. 1889.Google Scholar
  19. 19.
    Crocq. Contribution a L’étude expérimentale des artérites infectieuses. Arch méd Exp. 1894;6:583.Google Scholar
  20. 20.
    Klotz. The experimental production of arteriosclerosis. Br Med J. 1906;2:1767.Google Scholar
  21. 21.
    Fabricant CG, Fabricant J, Litrenta MM, Minick CR. Virus-induced atherosclerosis. J Exp Med. 1978;148:335–40.CrossRefGoogle Scholar
  22. 22.
    Thoma R. Über die Abhängigkeit der Bindegewebsneubildung in der Arterienintima von den mechanischen Bedingungen des Blutumlaufs. Virchows Arch. 1883;93:443–505.CrossRefGoogle Scholar
  23. 23.
    Diamond SL, Eskin SG, McIntire LV. Fluid flow stimulates tissue plasminogen activator secretion by cultured human endothelial cells. Science. 1989;243:1483–5.CrossRefGoogle Scholar
  24. 24.
    Kosaki K, Ando J, Korenaga R, et al. Fluid shear stress increases the production of granulocyte-macrophage colony-stimulating factor by endothelial cells via mRNA stabilization. Circ Res. 1998;82:794–802.CrossRefGoogle Scholar
  25. 25.
    Thubrikar MJ, Robicsek F. Pressure-induced arterial wall stress and atherosclerosis. Ann Thorac Surg. 1995;59:1594–603.CrossRefGoogle Scholar
  26. 26.
    Shaaban AM, Duerinckx AJ. Wall shear stress and early atherosclerosis: a review. AJR Am J Roentgenol. 2000;174:1657–65.  https://doi.org/10.2214/ajr.174.6.1741657.CrossRefPubMedGoogle Scholar
  27. 27.
    Cunningham KS, Gotlieb AI. The role of shear stress in the pathogenesis of atherosclerosis. Lab Invest. 2005;85:9–23.  https://doi.org/10.1038/labinvest.3700215.CrossRefPubMedGoogle Scholar
  28. 28.
    Stone PH, Maehara A, Coskun AU, et al. Role of low endothelial shear stress and plaque characteristics in the prediction of nonculprit major adverse cardiac events: the PROSPECT study. JACC Cardiovasc Imaging. 2018;11:462–71.  https://doi.org/10.1016/j.jcmg.2017.01.031.CrossRefPubMedGoogle Scholar
  29. 29.
    Virchow R. Cellular pathology. 1860.Google Scholar
  30. 30.
    Adams CW. Arteriosclerosis in man, other mammals and birds. Biol Rev Camb Philos Soc. 1964;39:372–423.CrossRefGoogle Scholar
  31. 31.
    Dahme EG. Atherosclerosis and arteriosclerosis in domestic animals. Ann NY Acad Sci. 1965;127:657–70.  https://doi.org/10.1164/arrd.1978.118.6.1101.CrossRefPubMedGoogle Scholar
  32. 32.
    Sandison AT. Degenerative vascular disease in the Egyptian mummy. Med Hist. 1962;6:77–81.CrossRefGoogle Scholar
  33. 33.
    Thompson RC, Allam AH, Lombardi GP, et al. Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations. Lancet (London, England). 2013;381:1211–22.  https://doi.org/10.1016/S0140-6736(13)60598-X.CrossRefGoogle Scholar
  34. 34.
    Allam AH, Thompson RC, Wann LS, et al. Atherosclerosis in ancient Egyptian mummies: the Horus study. JACC Cardiovasc Imaging. 2011;4:315–27.  https://doi.org/10.1016/j.jcmg.2011.02.002.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Hannover Medical SchoolHannoverGermany

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