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The mRNA Metabolism in Human Disease pp 1–27Cite as

Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1157))

Abstract

mRNA processing events introduce an intricate layer of complexity into gene expression processes, supporting a tremendous level of diversification of the genome’s coding and regulatory potential, particularly in vertebrate species. The recent development of massive parallel sequencing methods and their adaptation to the identification and quantification of different RNA species and the dynamics of mRNA metabolism and processing has generated an unprecedented view over the regulatory networks that are established at this level, which contribute to sustain developmental, tissue specific or disease specific gene expression programs. In this chapter, we provide an overview of the recent evolution of transcriptome profiling methods and the surprising insights that have emerged in recent years regarding distinct mRNA processing events – from the 5′ end to the 3′ end of the molecule.

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Authors and Affiliations

  1. Department of Human Genetics, National Institute of Health Doutor Ricardo Jorge, Lisboa, Portugal

    Peter Jordan & Vânia Gonçalves

  2. Faculty of Sciences, BioISI – Biosystems & Integrative Sciences Institute, University of Lisbon, Lisboa, Portugal

    Peter Jordan, Vânia Gonçalves, Marcelo Pereira & Margarida Gama-Carvalho

  3. Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

    Sara Fernandes

  4. Department of Chemistry and Biochemistry, Faculty of Sciences, University of Lisbon, Lisboa, Portugal

    Sara Fernandes, Tânia Marques & Margarida Gama-Carvalho

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Jordan, P., Gonçalves, V., Fernandes, S., Marques, T., Pereira, M., Gama-Carvalho, M. (2019). Networks of mRNA Processing and Alternative Splicing Regulation in Health and Disease. In: Romão, L. (eds) The mRNA Metabolism in Human Disease. Advances in Experimental Medicine and Biology, vol 1157. Springer, Cham. https://doi.org/10.1007/978-3-030-19966-1_1

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