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Challenges and Opportunities in Drug Delivery and Wound Healing

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Regenerative Medicine and Plastic Surgery

Abstract

Wound healing requires a convoluted systems biology interplay depending on the coordination of several cell types, intra- and extracellular mechanisms, proteins, and signaling pathways. Drugs meant to improve these interactions need to be delivered in a targeted and sustained fashion to effectively modulate the complex mechanisms involved in the response to injury. Specific drug delivery systems (DDS) are key for achieving this goal. An efficacious DDS prevents the wound from mechanical, oxidative, and enzymatic stress and from bacterial contamination and provides enough oxygen while maximizing localized and sustained drug delivery to the target tissue. In this chapter, we summarize the most promising recent advances in wound healing therapeutics with the corresponding delivery challenges and shed light on possible solutions for effective application.

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Authors and Affiliations

  1. Department of Plastic and Hand Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

    Matthias M. Aitzetmüller & Hans-Günther Machens

  2. Section of Plastic and Reconstructive Surgery, Department of Trauma, Hand and Reconstructive Surgery, Westfaelische Wilhelms, University of Muenster, Muenster, Germany

    Matthias M. Aitzetmüller

  3. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

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  1. Matthias M. Aitzetmüller
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  2. Hans-Günther Machens
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Correspondence to Matthias M. Aitzetmüller .

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  1. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

  2. Private Practice, Tustin, CA, USA

    Melvin A. Shiffman

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Aitzetmüller, M.M., Machens, HG., Duscher, D. (2019). Challenges and Opportunities in Drug Delivery and Wound Healing. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19962-3_3

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