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Regenerative Medicine and Plastic Surgery pp 347–353Cite as

Skeletal Muscle Restoration Following Volumetric Muscle Loss: The Therapeutic Effects of a Biologic Surgical Mesh

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Abstract

Biologic surgical meshes composed of extracellular matrix (ECM) are a promising treatment option for volumetric muscle loss (VML). The advantages of ECM-based therapies include the lack of a requirement for exogenous stem cell delivery and stimulation of a constructive, pro-healing immune response. This acellular approach lowers the regulatory and technical hurdles associated with stem cell administration, has superior outcomes compared to physical therapy alone or muscle grafting, and has the potential to improve quality of life by promoting functional myogenesis. This chapter reviews the current standard of care for VML and the preclinical and clinical studies supporting the use of biologic mesh as an inductive myogenesis template.

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Author information

Authors and Affiliations

  1. McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA

    Jenna L. Dziki, Jonas Eriksson & Stephen F. Badylak

  2. Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jenna L. Dziki & Jonas Eriksson

  3. Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Stephen F. Badylak

  4. Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA

    Stephen F. Badylak

Authors
  1. Jenna L. Dziki
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  2. Jonas Eriksson
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  3. Stephen F. Badylak
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Corresponding author

Correspondence to Stephen F. Badylak .

Editor information

Editors and Affiliations

  1. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

  2. Private Practice, Tustin, CA, USA

    Melvin A. Shiffman

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Dziki, J.L., Eriksson, J., Badylak, S.F. (2019). Skeletal Muscle Restoration Following Volumetric Muscle Loss: The Therapeutic Effects of a Biologic Surgical Mesh. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19962-3_24

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