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Absorbable Bone Substitute Materials Based on Calcium Sulfate as Triggers for Osteoinduction and Osteoconduction

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Regenerative Medicine and Plastic Surgery

Abstract

Calcium sulfate (CS) is employed as a bone substitute in a variety of clinical constellations and can additionally be antibiotically impregnated. These loaded bone substitutes can be applied in orthopedic and trauma surgery for prevention or treatment of bone infections. Its fast biodegradation reveals some concerns and limits the use. Addition of calcium carbonate and tripalmitin renders CS formulations hydrophobic and more resistant to rapid resorption leaving more time for bone formation due to the prolonged degradation process. Biocompatibility and degradation properties of newly formulated antibiotically impregnated CS preparations were examined in detail by implantation into the tibial metaphysis of rabbits. All CS preparations yielded good osteogenesis in association to the implants. None of the analyzed CS preparations triggered contact activation. Every implant demonstrated excellent biocompatibility, with some implants additionally showing excellent features as osteoconductive and -inductive scaffolds and potential for improvement of mechanical stability.

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Acknowledgments

At first, we would like to thank Mr. Dr. H. Büchner and Mr. Dr. S. Vogt (Heraeus Medical GmbH, Wehrheim, Germany) for their kind supply of bone substitute materials (Herafill®-G, as well as CaSO4-V). Second, many thanks to the central preclinical research division (ZPF) of the Klinikum rechts der Isar at the Technical University of Munich for their excellent support in performing the animal study. Especially, many thanks to Mrs. Dr. M. Rößner and Prof. Dr. H. Gollwitzer for their guidance in surgical procedure. Also, many thanks to Mrs. Dr. S. Kerschbaumer for generating and interpreting histological slices. Moreover, special thanks to Prof. Dr. P. Augat (Department of Biomechanics at the Unfallklinik Murnau) for his kind support in micro-CT investigations. Our special gratitude goes to Dr. Meredith Kiokekli for co-conduction of the experiments as well as to Mr. F. Seidl (M.A. Interpreting and Translating, MBA) for his kind support due to his perfect command of scientific English.

Disclaimer: Parts of this scientific article have by the authors previously been published in Journal of Material Science Materials in Medicine (Springer International Publishing AG). Reproduction was permitted by Springer.

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Authors and Affiliations

  1. Klinik und Poliklinik für Unfallchirurgie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

    Dominik Pförringer & Andreas Obermeier

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  1. Dominik Pförringer
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  2. Andreas Obermeier
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Correspondence to Dominik Pförringer .

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Editors and Affiliations

  1. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

  2. Private Practice, Tustin, CA, USA

    Melvin A. Shiffman

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Pförringer, D., Obermeier, A. (2019). Absorbable Bone Substitute Materials Based on Calcium Sulfate as Triggers for Osteoinduction and Osteoconduction. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19962-3_15

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