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Regenerative Medicine and Plastic Surgery pp 181–209Cite as

Ordinary and Activated Bone Substitutes

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Abstract

Bone substitutes are highly demanded in clinical practice for grafting of bone defects and alveolar ridge augmentation. Based on the analysis of modern groups of bone substitutes, particularities of their composition, mechanisms of biological effects, and therapeutic indications, applicable classification was proposed which consisted of separation of these materials to “ordinary” and “activated.” The main differential criterion is a presence of biologically active components in the material which are standardized by qualitative and quantitative parameters: growth factors, cells, or gene constructs encoding growth factors. The pronounced osteoinductive and (or) osteogenic properties of activated bone substitutes allow to draw upon their efficacy in substitution of large bone defects.

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Authors and Affiliations

  1. Department of Maxillofacial Surgery, A.I. Burnazyan Federal Medical Biophysical Center of FMBA of Russia, Moscow, Russia

    Ilya Y. Bozo

  2. “Histograft”, LLC, Moscow, Russia

    Ilya Y. Bozo & R. V. Deev

  3. Department of General Pathology, I.P. Pavlov Ryazan State Medical University, Ryazan, Russia

    R. V. Deev

  4. PJSC “Human Stem Cells Institute”, Moscow, Russia

    R. V. Deev & A. A. Isaev

  5. Department of Maxillofacial and Plastic Surgery, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia

    A. Y. Drobyshev

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  1. Ilya Y. Bozo
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  2. R. V. Deev
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  3. A. Y. Drobyshev
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  4. A. A. Isaev
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Editors and Affiliations

  1. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

  2. Private Practice, Tustin, CA, USA

    Melvin A. Shiffman

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Bozo, I.Y., Deev, R.V., Drobyshev, A.Y., Isaev, A.A. (2019). Ordinary and Activated Bone Substitutes. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19962-3_14

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