Skip to main content

Drug Delivery Advances for the Regeneration of Aged Skin

  • Chapter
  • First Online:
Regenerative Medicine and Plastic Surgery

Abstract

Due to a permanent shift of the human population towards higher age, also skin aging, its underlying mechanisms and possibilities to reverse these alterations have gained more attention. Although main triggering factors for aging skin degeneration have been identified, mitigating the signs of cutaneous aging is an ongoing scientific challenge. One promising alley of research is drug delivery systems (DDS) for systemic or local administration of regenerative compounds. DDS can enhance the efficacy of regenerative agents while minimizing side effects and enable the specific targeting of certain structures within the integument.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Reddy VJ, Radhakrishnan S, Ravichandran R, Mukherjee S, Balamurugan R, Sundarrajan S, Ramakrishna S. Nanofibrous structured biomimetic strategies for skin tissue regeneration. Wound Repair Regen. 2013;21(1):1–16.

    Google Scholar 

  2. Korrapati PS, Karthikeyan K, Satish A, Krishnaswamy VR, Venugopal JR, Ramakrishna S. Recent advancements in nanotechnological strategies in selection, design and delivery of biomolecules for skin regeneration. Mat Sci Eng C Mater Biol Appl. 2016;67:747–65.

    CAS  Google Scholar 

  3. Tobin DJ. Introduction to skin aging. J Tissue Viability. 2017;26(1):37–46.

    PubMed  Google Scholar 

  4. Gragnani A, Mac Cornick S, Chominski V, de Noronha SMR, de Noronha SAAC, Ferreira LM. Review of major theories of skin aging. Adv Aging Res. 2014;3(04):265.

    Google Scholar 

  5. Farage MA, Miller KW, Elsner P, Maibach HI. Characteristics of the aging skin. Adv Wound Care. 2013;2(1):5–10.

    Google Scholar 

  6. Krutmann J. Skin aging. In: Krutmann J, Humbert P, editors. Nutrition for healthy skin. Berlin: Springer; 2010. p. 15–24.

    Google Scholar 

  7. Duscher D, Barrera J, Wong VW, Maan ZN, Whittam AJ, Januszyk M, Gurtner GC. Stem cells in wound healing: the future of regenerative medicine? A mini-review. Gerontology. 2016;62(2):216–25.

    CAS  PubMed  Google Scholar 

  8. Kamolz LP, Griffith M, Finnerty C, Kasper C. Skin regeneration, repair, and reconstruction. Biomed Res Int. 2015;2015:892031.

    PubMed  PubMed Central  Google Scholar 

  9. Diegelmann RF, Evans MC. Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci. 2004;9(1):283–9.

    CAS  PubMed  Google Scholar 

  10. National Institute on Aging. Global health and aging. 2011. https://www.nia.nih.gov/research/dbsr/global-aging. Accessed 3 Jun 2018.

  11. Mustoe T. Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy. Am J Surg. 2004;187(5):S65–70.

    Google Scholar 

  12. Sheikhpour M, Barani L, Kasaeian A. Biomimetics in drug delivery systems: a critical review. J Control Release. 2017;253:97–109.

    CAS  PubMed  Google Scholar 

  13. Devi VK, Jain N, Valli KS. Importance of novel drug delivery systems in herbal medicines. Pharmacogn Rev. 2010;4(7):27.

    PubMed  PubMed Central  Google Scholar 

  14. Park K. Controlled drug delivery systems: past forward and future back. J Control Release. 2014;190:3–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Yun Y, Lee BK, Park K. Controlled drug delivery systems: the next 30 years. Front Chem Sci Eng. 2014;8(3):276–9.

    CAS  Google Scholar 

  16. Bertens C, Gijs M, Nuijts R, van den Biggelaar F. Topical drug delivery devices: a review. Exp Eye Res. 2018;168:149–60.

    CAS  PubMed  Google Scholar 

  17. Shargel L, Yu A, Wu-Pong S. Introduction to biopharmaceutics and pharmacokinetics. In: Shargel L, Yu A, Wu-Pong S, editors. Applied biopharmaceutics and pharmacokinetics. 6th ed. New York: McGraw-Hill; 2012. p. 1–17.

    Google Scholar 

  18. Ramasamy T, Ruttala HB, Gupta B, Poudel BK, Choi H-G, Yong CS, Kim JO. Smart chemistry-based nanosized drug delivery systems for systemic applications: a comprehensive review. J Control Release. 2017;258:226–53.

    CAS  PubMed  Google Scholar 

  19. Tong R, Christian DA, Tang L, Cabral H, Baker JR, Kataoka K, Discher DE, Cheng J. Nanopolymeric therapeutics. MRS Bull. 2009;34(6):422–31.

    CAS  Google Scholar 

  20. Ramasamy T, Kim JO, Yong CS, Umadevi K, Rana D, Jiménez C, Campos J, Haidar ZS. Novel core–shell nanocapsules for the tunable delivery of bioactive rhEGF: formulation, characterization and cytocompatibility studies. J Biomater Tiss Eng. 2015;5(9):730–43.

    Google Scholar 

  21. Ramasamy T, Kim JH, Choi JY, Tran TH, Choi H-G, Yong CS, Kim JO. pH sensitive polyelectrolyte complex micelles for highly effective combination chemotherapy. J Mater Chem B. 2014;2(37):6324–33.

    CAS  PubMed  Google Scholar 

  22. Tran TN. Cutaneous drug delivery: an update. J Investig Dermatol Symp Proc. 2013;16:S67–9.

    CAS  PubMed  Google Scholar 

  23. Alvarez-Román R, Naik A, Kalia Y, Guy RH, Fessi H. Skin penetration and distribution of polymeric nanoparticles. J Control Release. 2004;99(1):53–62.

    PubMed  Google Scholar 

  24. Blume-Peytavi U, Vogt A. Human hair follicle: reservoir function and selective targeting. Br J Dermatol. 2011;165(s2):13–7.

    CAS  PubMed  Google Scholar 

  25. Chourasia R, Jain SK. Drug targeting through pilosebaceous route. Curr Drug Targets. 2009;10(10):950–67.

    CAS  PubMed  Google Scholar 

  26. Baena-Aristizábal CM, Mora-Huertas CE. Micro, nano and molecular novel delivery systems as carriers for herbal materials. J Colloid Sci Biotechnol. 2013;2(4):263–97.

    Google Scholar 

  27. Laouini A, Jaafar-Maalej C, Limayem-Blouza I, Sfar S, Charcosset C, Fessi H. Preparation, characterization and applications of liposomes: state of the art. J Colloid Sci Biotechnol. 2012;1(2):147–68.

    CAS  Google Scholar 

  28. Jada A. A special issue on inorganic colloidal particles, synthesis, surface properties and applications. J Colloid Sci Biotechnol. 2014;3(1):1–2.

    Google Scholar 

  29. Sala M, Elaissari A, Fessi H. Advances in psoriasis physiopathology and treatments: up to date of mechanistic insights and perspectives of novel therapies based on innovative skin drug delivery systems (ISDDS). J Control Release. 2016;239:182–202.

    CAS  PubMed  Google Scholar 

  30. Lira AAM, Cordo PL, Nogueira EC, Almeida EDP, Junior RAL, Nunes RS, Rogéria S, Bentley MVLB, Marchetti JM. Optimization of topical all-trans retinoic acid penetration using poly-dl-lactide and poly-dl-lactide-co-glycolide microparticles. J Colloid Sci Biotechnol. 2013;2(2):123–9.

    CAS  Google Scholar 

  31. Rosset V, Ahmed N, Zaanoun I, Stella B, Fessi H, Elaissari A. Elaboration of argan oil nanocapsules containing naproxen for cosmetic and transdermal local application. J Colloid Sci Biotechnol. 2012;1(2):218–24.

    CAS  Google Scholar 

  32. Zhao Y, Brown MB, Jones SA. Pharmaceutical foams: are they the answer to the dilemma of topical nanoparticles? Nanomedicine. 2010;6(2):227–36.

    CAS  PubMed  Google Scholar 

  33. Raza K, Singh B, Lohan S, Sharma G, Negi P, Yachha Y, Katare OP. Nano-lipoidal carriers of tretinoin with enhanced percutaneous absorption, photostability, biocompatibility and anti-psoriatic activity. Int J Pharm. 2013;456(1):65–72.

    CAS  PubMed  Google Scholar 

  34. Pickart L, Vasquez-Soltero JM, Margolina A. GHK and DNA: resetting the human genome to health. Biomed Res Int. 2014;2014:151479.

    PubMed  PubMed Central  Google Scholar 

  35. Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu2+. FEBS Lett. 1988;238(2):343–6.

    CAS  PubMed  Google Scholar 

  36. Pickart L, Vasquez-Soltero JM, Margolina A. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. Biomed Res Int. 2015;2015:648108.

    PubMed  PubMed Central  Google Scholar 

  37. Pereira RF, Barrias CC, Granja PL, Bartolo PJ. Advanced biofabrication strategies for skin regeneration and repair. Nanomedicine (Lond). 2013;8(4):603–21.

    CAS  Google Scholar 

  38. Leonida MD, Kumar I. Bionanomaterials for skin regeneration. Cham: Springer Nature; 2016.

    Google Scholar 

  39. Gregoriadis G, Florence AT. Liposomes in drug delivery. Drugs. 1993;45(1):15–28.

    CAS  PubMed  Google Scholar 

  40. Yu HY, Liao HM. Triamcinolone permeation from different liposome formulations through rat skin in vitro. Int J Pharm. 1996;127(1):1–7.

    CAS  Google Scholar 

  41. Sinico C, Manconi M, Peppi M, Lai F, Valenti D, Fadda AM. Liposomes as carriers for dermal delivery of tretinoin: in vitro evaluation of drug permeation and vesicle–skin interaction. J Control Release. 2005;103(1):123–36.

    CAS  PubMed  Google Scholar 

  42. Brown GL, Curtsinger LJ, White M, Mitchell RO, Pietsch J, Nordquist R, von Fraunhofer A, Schultz GS. Acceleration of tensile strength of incisions treated with EGF and TGF-beta. Ann Surg. 1988;208(6):788.

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Gallarate M, Chirio D, Trotta M, Eugenia Carlotti M. Deformable liposomes as topical formulations containing α-tocopherol. J Dispers Sci Technol. 2006;27(5):703–13.

    CAS  Google Scholar 

  44. Fesq H, Lehmann J, Kontny A, Erdmann I, Theiling K, Rother M, Ring J, Cevc G, Abeck D. Improved risk–benefit ratio for topical triamcinolone acetonide in Transfersome® in comparison with equipotent cream and ointment: a randomized controlled trial. Br J Dermatol. 2003;149(3):611–9.

    CAS  PubMed  Google Scholar 

  45. Draelos ZD. Enhancement of topical delivery with nanocarriers. In: Nasir A, Friedman A, Wang S, editors. Nanotechnology in dermatology. New York: Springer; 2013. p. 87–93.

    Google Scholar 

  46. Müller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev. 2002;54:S131–S55.

    PubMed  Google Scholar 

  47. Jenning V, Schäfer-Korting M, Gohla S. Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J Control Release. 2000;66(2–3):115–26.

    CAS  PubMed  Google Scholar 

  48. Barry BW. Breaching the skin’s barrier to drugs. Nat Biotechnol. 2004;22(2):165.

    CAS  PubMed  Google Scholar 

  49. Mehnert W, Mäder K. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev. 2012;64:83–101.

    Google Scholar 

  50. Schäfer-Korting M, Mehnert W, Korting H-C. Lipid nanoparticles for improved topical application of drugs for skin diseases. Adv Drug Deliv Rev. 2007;59(6):427–43.

    PubMed  Google Scholar 

  51. Santos Maia C, Mehnert W, Schaller M, Korting H, Gysler A, Haberland A, Schäfer-Korting M. Drug targeting by solid lipid nanoparticles for dermal use. J Drug Target. 2002;10(6):489–95.

    CAS  PubMed  Google Scholar 

  52. Gainza G, Pastor M, Aguirre JJ, Villullas S, Pedraz JL, Hernandez RM, Igartua M. A novel strategy for the treatment of chronic wounds based on the topical administration of rhEGF-loaded lipid nanoparticles: in vitro bioactivity and in vivo effectiveness in healing-impaired db/db mice. J Control Release. 2014;185:51–61.

    CAS  PubMed  Google Scholar 

  53. Ueda H, Tabata Y. Polyhydroxyalkanonate derivatives in current clinical applications and trials. Adv Drug Deliv Rev. 2003;55(4):501–18.

    CAS  PubMed  Google Scholar 

  54. Tateshita T, Ono I, Kaneko F. Effects of collagen matrix containing transforming growth factor (TGF)-β1 on wound contraction. J Dermatol Sci. 2001;27(2):104–13.

    CAS  PubMed  Google Scholar 

  55. Inoue M, Ono I, Tateshita T, Kuroyanagi Y, Shioya N. Effect of a collagen matrix containing epidermal growth factor on wound contraction. Wound Repair Regen. 1998;6(3):213–22.

    CAS  PubMed  Google Scholar 

  56. Augustine R, Dominic EA, Reju I, Kaimal B, Kalarikkal N, Thomas S. Electrospun polycaprolactone membranes incorporated with ZnO nanoparticles as skin substitutes with enhanced fibroblast proliferation and wound healing. RSC Adv. 2014;4(47):24777–85.

    CAS  Google Scholar 

  57. Shirazi RN, Aldabbagh F, Erxleben A, Rochev Y, McHugh P. Nanomechanical properties of poly (lactic-co-glycolic) acid film during degradation. Acta Biomater. 2014;10(11):4695–703.

    CAS  PubMed  Google Scholar 

  58. Mohamed A, Xing MM. Nanomaterials and nanotechnology for skin tissue engineering. Int J Burns Trauma. 2012;2(1):29.

    CAS  PubMed  PubMed Central  Google Scholar 

  59. Wong VW, Levi B, Rajadas J, Longaker MT, Gurtner GC. Stem cell niches for skin regeneration. Int J Biomater. 2012;2012:926059.

    PubMed  PubMed Central  Google Scholar 

  60. Huang S, Lu G, Wu Y, Jirigala E, Xu Y, Ma K, Fu X. Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair. J Dermatol Sci. 2012;66(1):29–36.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Matthias M. Aitzetmüller .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Pérez, D.C., Aitzetmüller, M.M., Neßbach, P., Duscher, D. (2019). Drug Delivery Advances for the Regeneration of Aged Skin. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19962-3_12

Download citation

Publish with us

Policies and ethics