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Stem Cell Differentiation Directed by Material and Mechanical Cues

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Regenerative Medicine and Plastic Surgery

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Abstract

Stem cells play a crucial role in regenerative processes. They are heavily influenced by their microenvironment and, depending on the external signal, stem cells self-renew and differentiate toward specific lineages. It is critical to understand the diverse mechanical and material cues that induce stem cell behavior to harness these changes for tissue engineering applications. As such, significant advances have been made in regenerative approaches to breast reconstruction. In this review, we will discuss the role of extracellular signals in guiding stem cell differentiation and stress the role of material and mechanical cues that influence mammary adipose and epithelial tissues in the context of breast reconstruction.

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Author information

Authors and Affiliations

  1. Division of Plastic Surgery, Department of General Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA

    Caitlyn A. Moore, Alexandra Condé-Green, Pranela Rameshwar & Mark S. Granick

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  1. Caitlyn A. Moore
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  2. Alexandra Condé-Green
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  3. Pranela Rameshwar
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  4. Mark S. Granick
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Corresponding author

Correspondence to Mark S. Granick .

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Editors and Affiliations

  1. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

  2. Private Practice, Tustin, CA, USA

    Melvin A. Shiffman

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Moore, C.A., Condé-Green, A., Rameshwar, P., Granick, M.S. (2019). Stem Cell Differentiation Directed by Material and Mechanical Cues. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19958-6_7

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