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Nonpharmacological Management of BPSD: Agitation and Behavioral Problems in Dementia

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Geriatric Practice

Abstract

Caregivers identify BPSD as one of the most challenging and distressing aspects of care. The presence of BPSD, especially physical aggression, is a leading cause of nursing home placement. These behaviors can have an immense impact on the quality of life of both the patient and the caregiver. This chapter has been created to help the primary care provider have a structured approach to the evaluation and management of BPSD.

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References

  1. Alzheimer’s disease facts and figures. Alzheimer’s Dement. 2016;12(4):459–509.

    Google Scholar 

  2. Alzheimer’s Disease International. Dementia statistics. https://www.alz.co.uk/research/statistics. Accessed 27 Dec 2017.

  3. Ayalon L, Gum AM, Feliciano L, Areán PA. Effectiveness of nonpharmacological interventions for the management of neuropsychiatric symptoms in patients with dementia: a systematic review. Arch Intern Med. 2006;166(20):2182–8.

    Article  PubMed  Google Scholar 

  4. Badrakalimnthu VR, Tarbuck AF. Anxiety: a hidden element in dementia. Adv Psychiatr Treat. 2012;18(2):119–28.

    Article  Google Scholar 

  5. Bird M, Jones RH, Korten A, Smithers H. A controlled trial of a predominantly psychosocial approach to BPSD: treating causality. Int Psychogeriatr. 2007;19(5):874–91. Epub 2007 Jan 19.

    Article  PubMed  Google Scholar 

  6. Bliwise DL. Sleep disorders in Alzheimer’s disease and other dementias. Clin Cornerstone. 2004;6. Suppl 1A:S16–28.

    Article  PubMed  Google Scholar 

  7. Cohen-Mansfield J. Nonpharmacologic interventions for inappropriate behaviors in dementia: a review, summary, and critique. Am J Geriatr Psychiatry. 2001;9(4):361–81.

    Article  CAS  PubMed  Google Scholar 

  8. Cohen-Mansfield J, Thein K, Marx MS, Dakheel-Ali M, Freedman L. Efficacy of nonpharmacologic interventions for agitation in advanced dementia: a randomized, placebo-controlled trial. J Clin Psychiatry. 2012;73(9):1255–61. https://doi.org/10.4088/JCP.12m07918.

    Article  PubMed  Google Scholar 

  9. Collins J, Harris D, LeClair K. Putting the PIECES Together, The PIECES Collaboration Office. Shop for Learning Publishing, 6th Edition. 2010.

    Google Scholar 

  10. Cooke JR, Ancoli-Israel S. Normal and abnormal sleep in the elderly. Handb Clin Neurol. 2011;98:653–65.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Deschenes CL, McCurry SM. Current treatments for sleep disturbances in individuals with dementia. Curr Psychiatry Rep. 2009;11:20.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Drouillard N, Mithani A, Chan PKY. Therapeutic approaches in the management of behavioral and psychological symptoms of dementia in the elderly. B C Med J. 2013;55(2):90–5.

    Google Scholar 

  13. Duffin C. How Namaste principles improve resident’ lives. Nurs Older People. 2012;24(6):14–7.

    Article  PubMed  Google Scholar 

  14. Dyer SM, Harrison SL, Laver K, Whitehead C, Crotty M. An overview of systematic reviews of pharmacological and non-pharmacological interventions for the treatment of behavioral and psychological symptoms of dementia. Int Psychogeriatr. 2017;16:1–15. https://doi.org/10.1017/S1041610217002344.

    Article  Google Scholar 

  15. Fakhoury N, Wilhelm N, Sobota KF, Kroustos KR. Impact of music therapy on dementia behaviors: a literature review. Consult Pharm. 2017;32(10):623–8.

    Article  PubMed  Google Scholar 

  16. Fujii M, Hatakeyama R, Fukuoka Y, et al. Lavender aroma therapy for behavioral and psychological symptoms in dementia patients. Geriatr Gerontol Int. 2008;8(2):136–8.

    Article  PubMed  Google Scholar 

  17. Gill SS, Bronskill SE, Normand SL, Anderson GM, Sykora K, Lam K, Bell CM, Lee PE, Fischer HD, Herrmann N, Gurwitz JH, Rochon PA. Antipsychotic drug use and mortality in older adults with dementia. Ann Intern Med. 2007;146:775–86.

    Article  PubMed  Google Scholar 

  18. Gitlin LN, Kales HC, Lyketsos CG. Managing behavioral symptoms in dementia using nonpharmacologic approaches: an overview. JAMA. 2012;308(19):2020–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Gitlin LN, Winter L, Dennis MP, Hodgson N, Hauck WW. Targeting and managing behavioral symptoms in individuals with dementia: a randomized trial of a nonpharmacological intervention. J Am Geriatr Soc. 2010;58(8):1465–74.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Gitlin LN, Winter L, Dennis MP, Hodgson N, Hauck WW. A biobehavioral home-based intervention and the well-being of patients with dementia and their caregivers: the COPE randomized trial. JAMA. 2010;304(9):983–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Gu L. Nursing interventions in managing wandering behavior in patients with dementia: a literature review. Arch Psychiatr Nurs. 2015;29(6):454–7.

    Article  PubMed  Google Scholar 

  22. Guideline Adaptation Committee. Clinical practice guidelines and principles of care for people with dementia. Sydney: NHMRC Cognitive Decline Partnership Centre; 2016. Available at: http://www.clinicalguidelines.gov.au/portal/2503/clinical-practice-guidelines-and-principles-care-people-dementia.

    Google Scholar 

  23. Hepburn KW, Lewis M, Sherman CW, et al. The Savvy Caregiver Program: developing and testing a transportable dementia family caregiver training program. Gerontologist. 2003;43:908–15.

    Article  PubMed  Google Scholar 

  24. Hermans DG, Tay H, Hla U, McShane R. Non-pharmacological interventions for wandering of people with dementia in the domestic setting. [Systematic Review] Cochrane Dementia and Cognitive Improvement Group Cochrane Database of Systematic Reviews. 2007;4.

    Google Scholar 

  25. Hurt C, et al. Patient and caregiver perspectives of quality of life in dementia. An investigation of the relationship to behavioural and psychological symptoms in dementia. Dement Geriatr Cogn Disord. 2008;26:138–46.

    Article  PubMed  Google Scholar 

  26. Husebo BS, Ballard C, Aarsland D. Pain treatment of agitation in patients with dementia: a systematic review. Int J Geriatr Psychiatry. 2011;26(10):1012–8. https://doi.org/10.1002/gps.2649. Epub 2011 Feb 9.

    Article  CAS  PubMed  Google Scholar 

  27. Hwang R. Managing difficult behaviors in patients with dementia. Virtual Mentor. 2008;10(6):379–82.

    PubMed  Google Scholar 

  28. Inouye SK. The confusion assessment method (CAM): training manual and coding guide 2003. Boston: Yale University School of Medicine; 2003.

    Google Scholar 

  29. Jeste DV, Blazer D, Casey D, Meeks T, Salzman C, Schneider L, Tariot P, Yaffe K. ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia. Neuropsychopharmacology. 2008;33:957–70.

    Article  CAS  PubMed  Google Scholar 

  30. Kales HC, Gitlin LN, Lyketsos CG. Assessment and management of behavioral and psychological symptoms of dementia. BMJ. 2015;350:h369.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Kales HC, Gitlin LN, Stanislawski B, Marx K, Turnwald M, Watkins DC, Lyketsos CG. WeCareAdvisor™: the development of a caregiver-focused, web-based program to assess and manage behavioral and psychological symptoms of dementia. Alzheimer Dis Assoc Disord. 2017;31(3):263–70.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Kar N. Behavioral and psychological symptoms of dementia and their management. Indian J Psychiatry. 2009;51(Suppl 1):s77–86.

    PubMed  PubMed Central  Google Scholar 

  33. Kok JS, van Heuvelen MJG, Berg IJ, Scherder EJA. Small scale homelike special care units and traditional special care units: effects on cognition in dementia; a longitudinal controlled intervention study. BMC Geriatr. 2016;16:47.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Kong EH, Evans LK, Guevara JP. Nonpharmacological intervention for agitation in dementia: a systematic review and meta-analysis. Aging Ment Health. 2009;13:512–20.

    Article  PubMed  Google Scholar 

  35. Kovach CR, Taneli Y, Dohearty P, et al. Effect of the BACE intervention on agitation in people with dementia. Gerontologist. 2004;44:797–806. [PubMed: 15611216].

    Article  PubMed  Google Scholar 

  36. Lin PW, Chan WC, Ng BF, Lam LC. Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross-over randomized trial. Int J Geriatr Psychiatry. 2007;22(5):405–10.

    Article  PubMed  Google Scholar 

  37. Livingston G, Johnston K, Katona C, et al. Systematic review of psychological approaches to the management of neuropsychiatric symptoms of dementia. Am J Psychiatry. 2005;162(11):1996–2021.

    Article  PubMed  Google Scholar 

  38. Livingston G, Kelly L, Lewis-Holmes E, et al. Non-pharmacological interventions for agitation in dementia: systematic review of randomised controlled trials. Br J Psychiatry. 2014;205:436.

    Article  PubMed  Google Scholar 

  39. Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC. Mental and behavioral disturbances in dementia: findings from the cache county study on memory in aging. Am J Psychiatr. 2000;157:708–14.

    Article  CAS  PubMed  Google Scholar 

  40. McCurry SM, Gibbons LE, Logsdon RG, Vitiello MV, Teri L. Nighttime insomnia treatment and education for Alzheimer’s disease: a randomized, controlled trial. J Am Geriatr Soc. 2005;53(5):793–802.

    Article  PubMed  Google Scholar 

  41. McEvoy P, Eden J, Plant R. Dementia communication using empathic curiosity. Nurs Times. 2014;110(24):12–5.

    PubMed  Google Scholar 

  42. McGonigal-Kenny ML, Schutte DL. Nonpharmacologic management of agitated behaviors in persons with Alzheimer disease and other chronic dementing conditions. J Gerontol Nurs. 2006;32(2):9–14.

    Article  PubMed  Google Scholar 

  43. Mitchell SL. Advanced dementia. N Engl J Med. 2015;372(26):2533–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Moore M, Zhu C, Clipp E. Informal costs of dementia care: estimates from the national longitudinal caregiver study. J Gerontol B Psychol Sci Soc Sci. 2001;56:S219–28.

    Article  CAS  PubMed  Google Scholar 

  45. Moretti F, DeRonchi D, Bernabei V, et al. Pet therapy in elderly patients with mental illness. Psychogeriatrics. 2011;11(2):125–9.

    Article  PubMed  Google Scholar 

  46. National Institute for Health and Clinical Excellence-Social Care Institute for Excellence. Dementia. A NICE–SCIE guideline on supporting people with dementia and their carers in health and social care. London: National Clinical Practice Guideline London; 2007.

    Google Scholar 

  47. Nicholls D, Chang E, Johnson A, Edenborough M. Touch, the essence of caring for people with end-stage dementia: a mental health perspective in Namaste Care. Aging Ment Health. 2013;17(5):571–8.

    Article  PubMed  Google Scholar 

  48. Nordgren L, Engström G. Effects of dog-assisted interventions on behavioural and psychological symptoms of dementia. Nurs Older People. 2014;26(3):31–8.

    Article  PubMed  Google Scholar 

  49. Öhman H, Savikko N, Strandberg TE, et al. Effects of exercise on cognition: the Finnish Alzheimer disease exercise trial. J Am Geriatr Soc. 2016;64(4):731–8.

    Article  PubMed  Google Scholar 

  50. Caregiver- and patient-directed interventions for dementia an evidence-based analysis. Ont Health Technol Assess Ser. 2008;8(4):1–98.

    Google Scholar 

  51. Osser D, Fischer M. Management of the behavioral and psychological symptoms of dementia. NaRCAD (the National Resource Center for Academic Detailing) with support from a grant from the Agency for Healthcare Research and Quality to the Division of Pharmacoepidemiology and Pharmacoeconomics of the Brigham and Women’s Hospital Department of Medicine. 28 Dec 2013.

    Google Scholar 

  52. Ostwald SK, Hepburn KW, Caron W, et al. Reducing caregiver burden: a randomized psychoeducational intervention for caregivers of persons with dementia. Gerontologist. 1999;39:299–309. [PubMed: 10396888].

    Article  CAS  PubMed  Google Scholar 

  53. Paniagua MA, Paniagua EW. The demented elder with insomnia. Clin Geriatr Med. 2008;24(1):69–81, vii. Review.

    Google Scholar 

  54. Perry E. Aromatherapy for the treatment of Alzheimer’s disease. J Qual Res Dementia. 2016;3. https://unforgettable-media-unforgettabletra.netdna-ssl.com/media/attach.... Accessed 26 June 2017.

  55. Peter-Derex L, Yammine P, Bastuji H, Croisile B. Sleep and Alzheimer’s disease. Sleep Med Rev. 2015;19:29–38.

    Article  PubMed  Google Scholar 

  56. Petit D, Gagnon JF, Fantini ML, Ferini-Strambi L, Montplaisir J. Sleep and quantitative EEG in neurodegenerative disorders. J Psychosom Res. 2004;56(5):487–96.

    Article  PubMed  Google Scholar 

  57. Press-Sandler O, Freud T, Volkov I, Peleg R, Press Y. Aromatherapy for the treatment of patients with behavioral and psychological symptoms of dementia: a descriptive analysis of RCTs. J Altern Complement Med. 2016;22(6):422–8.

    Article  PubMed  Google Scholar 

  58. Prinz PN, Peskind ER, Vitaliano PP, et al. Changes in the sleep and waking EEGs of nondemented and demented elderly subjects. J Am Geriatr Soc. 1982;30(2):86–93.

    Article  CAS  PubMed  Google Scholar 

  59. Puxty J, Rivard MF. Behavioural and psychological symptoms of dementia (BPSD): a handbook for family physicians. Ontario College of Family Physicians and P.I.E.C.E. Canada. 2009.

    Google Scholar 

  60. Rabins PV, et al. American Psychiatric Association practice guideline for the treatment of patients with Alzheimer’s disease and other dementias. Second edition. Am J Psychiatry. 2007;164(Suppl 12):5–56.

    PubMed  Google Scholar 

  61. Rosen HJ, Allison SC, Schauer GF, et al. Neuroanatomical correlates of behavioural disorders in dementia. Brain. 2005;128:2612.

    Article  PubMed  Google Scholar 

  62. Salzman C, Jeste D, Meyer RE, Cohen-Mansfield J, Cummings J, Grossberg G, Jarvik L, Kraemer H, Lebowitz B, Maslow K, Pollock B, Raskind M, Schultz S, Wang P, Zito JM, Zubenko GS. Elderly patients with dementia-related symptoms of severe agitation and aggression: consensus statement on treatment options, clinical trials methodology, and policy. J Clin Psychiatry. 2008;69(6):889–98.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Savva GM, et al. Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population. Br J Psychiatry. 2009;194:212–9.

    Article  PubMed  Google Scholar 

  64. Schneeweiss S, Setoguchi S, Brookhart A, Dormuth C, Wang PS. Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients. CMAJ. 2007;176:627–32.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Sloane PD, Hoeffer B, Mitchell CM, McKenzie DA, Barrick AL, Rader J, Stewart BJ, Talerico KA, Rasin JH, Zink RC, Koch GG. Effect of person-centered showering and the towel bath on bathing-associated aggression, agitation, and discomfort in nursing home residents with dementia: a randomized, controlled trial. J Am Geriatr Soc. 2004;52(11):1795–804.

    Article  PubMed  Google Scholar 

  66. Staddon JER, Cerutti DT. Operant conditioning. Annu Rev Psychol. 2003;54:115–44. https://doi.org/10.1146/annurev.psych.54.101601.​145124.

  67. Staedtler AV, Nunez D. Nonpharmacological therapy for the management of neuropsychiatric symptoms of Alzheimer’s disease: linking evidence to practice. Worldviews Evid Based Nurs. 2015;12(2):108–15. https://doi.org/10.1111/wvn.12086. Epub 2015 Mar 21.

    Article  PubMed  Google Scholar 

  68. Steele C, Rovner B, Chase GA, Folstein M. Psychiatric symptoms and nursing home placement of patients with Alzheimer’s disease. Am J Psychiatr. 1990;147:1049–51.

    Article  CAS  PubMed  Google Scholar 

  69. Stein-Parbury J, Chenoweth L, Jeon YH, Brodaty H, Haas M, Norman R. Implementing person-centered care in residential dementia care. Clin Gerontol. 2012;35(5):404–24.

    Article  Google Scholar 

  70. Subramanian P, Woods B. The impact of individual reminiscence therapy for people with dementia: systematic review. Expert Rev Neurother. 2012;12(5):545–55.

    Article  Google Scholar 

  71. Subramanian P, Woods B, Whitaker C. Life review and life story books for people with mild to moderate dementia: a randomized controlled trial. Aging Ment Health. 2014;18(3):363–75.

    Article  Google Scholar 

  72. Teri L, Gibbons LE, McCurry SM, et al. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA. 2003;290:2015.

    Article  CAS  PubMed  Google Scholar 

  73. Teri L, McCurry SM, Logsdon R, et al. Training community consultants to help family members improve dementia care: a randomized controlled trial. Gerontologist. 2005;45:802–11. [PubMed:16326662].

    Article  PubMed  Google Scholar 

  74. Tuohy D, Graham MM, Johnson K, Tuohy T, Burke K. Developing an educational DVD on the use of hand massage in the care of people with dementia: an innovation. Nurs Educ Pract. 2015;15(4):299–303.

    Article  Google Scholar 

  75. Urrestarazu E, Iriarte J. Clinical management of sleep disturbances in Alzheimer’s disease: current and emerging strategies. Nat Sci Sleep. 2016;8:21–33.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Viggo Hansen N, Jørgensen T, Ørtenblad L. Massage and touch for dementia. Cochrane Database Syst Rev. 2006;(4):CD004989.

    Google Scholar 

  77. Wong C, Leland NE. Non-pharmacological approaches to reducing negative behavioral symptoms: a scoping review. OTJR (Thorofare N J). 2016;36(1):34–4139.

    Google Scholar 

  78. www.agingbraincare.org/. ABC care protocols. The nonpharmacologic protocols.

  79. www.alz.org/care/alzheimers-dementia-bathing.asp.

  80. www.bathingwithoutabattle.unc.edu/.

  81. Zec RF, Burkett NR. Non-pharmacological and pharmacological treatment of the cognitive and behavioral symptoms of Alzheimer disease. NeuroRehabilitation. 2008;23(5):425–38.

    PubMed  Google Scholar 

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Appendices

Appendix 1: Confusion Assessment Method (CAM) Diagnosis of Delirium Requires a Present or Abnormal Rating for Criteria 1 and 2 Plus Either 3 or 4 [28]

Criteria

  1. 1.

    Acute onset and fluctuating course:

    • Is there evidence of an acute change in mental status from the patient’s baseline? Corroboration with caretakers and family member is usually required.

    • Did this behavior come and go or wax or wane in severity in the last 24 hours?

  2. 2.

    Inattention:

    • Does the patient have difficulty focusing attention?

    • Are they easily distracted?

    • Do they have difficulty keeping track of what is being said?

    • Consider asking the patient to recite the days of the week backwards.

  3. 3.

    Disorganized thinking:

    • Is the patient’s speech disorganized or incoherent?

    • Does the patient ramble or have irrelevant conversation that is unclear with illogical flow of ideas, and unpredictable switching between subjects?

  4. 4.

    Altered level of consciousness:

    • Only patients who are calm and alert are considered normal.

    • Patient meet criteria if they are: vigilant (hyperalert), lethargic (drowsy, easily aroused), stuporous (difficult to arouse), or comatose.

Appendix 2: Blackbox Warning for Antipsychotics [17, 64]

  • Increased risk of mortality. Rate of death was 1.6–1.7 times that of placebo (3.5 vs 2.3%).

  • Death appeared to be heart related or from infections (e.g., pneumonia).

  • Often causing diabetes mellitus, hyperglycemia, ketoacidosis, and hyperosmolar states.

  • All antipsychotic drugs will now include the same information about this risk in a BOXED WARNING and WARNING section.

  • Antipsychotics are NOT indicated for the treatment of dementia-related psychosis and are off-labeled use.

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Chang, C. (2020). Nonpharmacological Management of BPSD: Agitation and Behavioral Problems in Dementia. In: Chun, A. (eds) Geriatric Practice. Springer, Cham. https://doi.org/10.1007/978-3-030-19625-7_21

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