Abstract
Dynamical organization of bivalents during meiosis may play a significant role in the appearance of joint genic expression, as the result of persistent overlapping domains of constitutive pericentromeric heterochromatin coming from different bivalents during pachytene.
We present early findings of an ongoing research in which we apply standard global threshold segmentation techniques for assessing correlation between observed sizes of sets of overlapping heterochromatin domains in spreads of meiotic Mus m. domesticus 2n=40 spermatocytes during pachytene and their simulated counterparts.
Simulated spreads were produced ad libitum using a special non homogeneous Bernoulli site percolation process, called P-Percolation, acting upon the fullerene’s dual \(C'_{1200}\), in which clusters of pericentromeric heterochromatin are depicted by random chromatin neigborhoods (ranches) arising from a process characterized by a vector P of independent Bernoulli random variables. We show that under the hypothesis made, a vector P of at least three dimensions is needed for establishing coherence between observed and simulated values.
Supported by LabEx PERSYVAL-Lab (ANR-11-LABX-0025-01) funded by the French program Investissement d’avenir.
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Berríos, S., Fenner, J.L., Maignan, A. (2019). Random Chromatin Neighborhoods in 2n=40 Mus m. domesticus Meiotic Cells: P-Percolation and Image Segmentation. In: Chaves, M., Martins, M. (eds) Molecular Logic and Computational Synthetic Biology. MLCSB 2018. Lecture Notes in Computer Science(), vol 11415. Springer, Cham. https://doi.org/10.1007/978-3-030-19432-1_9
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DOI: https://doi.org/10.1007/978-3-030-19432-1_9
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