• Jordan S. Thomas
  • Justin M. DunnEmail author
Part of the Contemporary Cardiology book series (CONCARD)


Myocardial contractility—often referred to as inotropy—is the inherent capacity of the myocardium to contract independent of loading conditions, that is, preload and afterload (discussed in Chaps.  1 and  2, respectively). Thus, for a given preload and afterload, contractility is a manifestation of all other factors that influence the interactions between contractile proteins. The incorporation of all these factors makes a simple definition of “contractility” difficult, and it is more easily understood through discussions of changes in contractility. Clinically, a change in left ventricular contractility can be defined as a change in the work performed per beat at a constant end-diastolic volume and aortic pressure.


Ischemia Dopamine Lactate Pyruvate Norepinephrine 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Advanced Heart Failure/Transplant CardiologyOhio State UniversityColumbusUSA
  2. 2.Interventional CardiologySumma HealthAkronUSA

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