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Recurrent Pericarditis

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Periodic and Non-Periodic Fevers

Part of the book series: Rare Diseases of the Immune System ((RDIS))

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Abstract

Idiopathic recurrent pericarditis (IRP) is the most troublesome and common complication of acute pericarditis. The term “idiopathic” is used when infections (e.g., viruses or tuberculosis), neoplasms, and definite systemic diseases have been excluded. The diagnosis is based on the presence of typical symptoms and signs (pleuro-pericardial chest pain, pericardial rub, electrocardiographic alterations, pericardial effusion). Inflammatory markers and imaging techniques are confirmatory and help to manage the disease. Treatment includes the combination of nonsteroidal anti-inflammatory drugs (NSAIDs) at high dosage plus colchicine at low dosage; corticosteroids at medium-low dosages are often used, particularly in adult patients. In refractory cases, therapy with interleukin-1 inhibition has been remarkably effective.

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Abbreviations

AHA:

Anti-heart antibodies

AIDA:

Anti-intercalated-disk antibodies

AIRTRIP:

The Anakinra-Treatment of Recurrent Idiopathic Pericarditis

ANAs:

Antinuclear antibodies

AP-1:

Activator protein-1

APC:

Antigen-presenting cell

ASA:

Acetylsalicylic acid

CEACAM1:

Carcinoembryonic antigen cell adhesion molecule 1

CMR:

Cardiac magnetic resonance

CMV:

Cytomegalovirus

CRP:

C-reactive protein

CT:

Computerized tomography

DAMP:

Damage-associated molecular patterns

EBV:

Epstein-Barr virus

ECG:

Electrocardiogram

ESC:

European Society of Cardiology

ESR:

Erythrocyte sedimentation rate

HCV:

Hepatitis C virus

HIV:

Human immunodeficiency virus

HLA:

Human leukocyte antigens

HSV-1:

Herpes simplex virus

IL:

Interleukin

INF:

Interferonγ

IRP:

Idiopathic recurrent pericarditis

IVIg:

Intravenous immunoglobulins

MHC:

Major histocompatibility complex

MICA:

MHC class I chain-related protein A

NF-kB:

Nuclear factor-kappa B

NSAIDs:

Nonsteroidal anti-inflammatory drugs

PAMP:

Pathogen-associated molecular patterns

PPS:

Postpericardiotomy syndrome

STIR:

Short-tau inverted recovery

TLR:

Toll-like receptor

TNF:

Tumor necrosis factor

TRAPS:

TNF receptor–associated periodic fever syndrome

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Authors and Affiliations

  1. Dipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, Ospedale Fatebenefratelli, Milano, Italy

    Antonio Brucato

  2. Medicina Interna Ospedale Papa Giovanni XXIII, Bergamo, Italy

    Anna Valenti & Silvia Maestroni

Authors
  1. Antonio Brucato
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  2. Anna Valenti
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  3. Silvia Maestroni
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Correspondence to Silvia Maestroni .

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Editors and Affiliations

  1. Department of Clinical Sciences and Community Health, University of Milano, Milano, Italy

    Rolando Cimaz

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Brucato, A., Valenti, A., Maestroni, S. (2020). Recurrent Pericarditis. In: Cimaz, R. (eds) Periodic and Non-Periodic Fevers. Rare Diseases of the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-030-19055-2_7

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  • DOI: https://doi.org/10.1007/978-3-030-19055-2_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-19054-5

  • Online ISBN: 978-3-030-19055-2

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