Skip to main content

PET/CT with Standard Non-FDG Tracers in Multiple Myeloma

  • Chapter
  • First Online:
Book cover Molecular Imaging in Multiple Myeloma

Abstract and Aims

Beside FDG, there is an emerging role of non-FDG tracers for the evaluation of Multiple Myeloma at onset. This because it was proved that there may be a quote of low metabolic myelomas that may present a low FDG uptake, possibly resulting in an underestimation of the number of focal lesions.

This chapter aims to:

  • Discuss the causes of false negativity at FDG

  • Discuss the contribution of 11C-Methionine in Multiple Myeloma

  • Discuss the contribution of 11C-18F-Choline in Multiple Myeloma

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Rasche L, Angtuaco E, McDonald JE, Buros A, Stein C, Pawlyn C, Thanendrarajan S, Schinke C, Samant R, Yaccoby S, Walker BA, Epstein J, Zangari M, van Rhee F, Meissner T, Goldschmidt H, Hemminki K, Houlston R, Barlogie B, Davies FE, Morgan GJ, Weinhold N. Low expression of hexokinase-2 is associated with false-negative FDG-positron emission tomography in multiple myeloma. Blood. 2017;130(1):30–4. https://doi.org/10.1182/blood-2017-03-774422. Epub 2017 Apr 21. PubMed PMID: 28432222; PubMed Central PMCID: PMC5501152.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Kircher S, Stolzenburg A, Kortuem KM, Kircher M, Da Via M, Samnick S, Buck A, Einsele H, Rosenwald A, Lapa C. Hexokinase-2 expression in MET-positive FDG-negative multiple myeloma. J Nucl Med. 2018. pii: jnumed.118.217539. https://doi.org/10.2967/jnumed.118.217539. [Epub ahead of print]. PubMed PMID: 30389821.

    Article  PubMed  Google Scholar 

  3. Hammerton K, Cooper DA, Duckett M, Penny R. Biosynthesis of immunoglobulin in human immunoproliferative diseases. I. Kinetics of synthesis and secretion of immunoglobulin and protein by bone marrow cells in myeloma. J Immunol. 1978;121(2):409–17.

    CAS  PubMed  Google Scholar 

  4. Dankerl A, Liebisch P, Glatting G, Friesen C, Blumstein NM, Kocot D, Wendl C, Bunjes D, Reske SN. Molecular imaging with 11C-methionine PET/CT—initial experience. Radiology. 2007;242(2):498–508.

    Article  PubMed  Google Scholar 

  5. Lapa C, Knop S, Schreder M, Rudelius M, Knott M, Jörg G, Samnick S, Herrmann K, Buck AK, Einsele H, Lückerath K. 11C-Methionine-PET in multiple myeloma: correlation with clinical parameters and bone marrow involvement. Theranostics. 2016;6(2):254–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Okasaki M, Kubota K, Minamimoto R, Miyata Y, Morooka M, Ito K, Ishiwata K, Toyohara J, Inoue T, Hirai R, Hagiwara S, Miwa A. Comparison of (11)C-4′-thiothymidine, (11)C-methionine, and (18)F-FDG PET/CT for the detection of active lesions of multiple myeloma. Ann Nucl Med. 2015;29(3):224–32.

    Article  CAS  PubMed  Google Scholar 

  7. Lapa C, Garcia-Velloso MJ, Lückerath K, Samnick S, Schreder M, Otero PR, Schmid JS, Herrmann K, Knop S, Buck AK, Einsele H, San-Miguel J, Kortüm KM. (11)C-Methionine-PET in multiple myeloma: a combined study from two different institutions. Theranostics. 2017;7(11):2956–64. https://doi.org/10.7150/thno.20491. eCollection 2017. PubMed PMID: 28824728; PubMed Central PMCID: PMC5562228.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Mesguich C, Zanotti-Fregonara P, Hindié E. New perspectives offered by nuclear medicine for the imaging and therapy of multiple myeloma. Theranostics. 2016;6(2):287–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Sanz G, Rioja J, Zudaire JJ, Beria'n JM, Richter JA. PET and prostate cancer. World J Urol. 2004;22:351–2.

    Article  CAS  PubMed  Google Scholar 

  10. Ambrosini V, Farsad M, Nanni C, Rubello D, Fanti S. Image of the month: incidental finding of a 11C-choline PET positive solitary plasmacytoma lesion. Eur J Nucl Med Mol Imaging. 2006.

    Google Scholar 

  11. Nanni C, Zamagni E, Cavo M, Rubello D, Tacchetti P, Pettinato C, Farsad M, Castellucci P, Ambrosini V, Montini GC, Al-Nahhas A, Franchi R, Fanti S. 11C-choline vs. 18F-FDG PET/CT in assessing bone involvement in patients with multiple myeloma. World J Surg Oncol. 2007;5:68. PubMed PMID: 17584499; PubMed Central PMCID: PMC1913918.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Cassou-Mounat T, Balogova S, Nataf V, Calzada M, Huchet V, Kerrou K, Devaux JY, Mohty M, Talbot JN, Garderet L. 18F-fluorocholine versus 18F-fluorodeoxyglucose for PET/CT imaging in patients with suspected relapsing or progressive multiple myeloma: a pilot study. Eur J Nucl Med Mol Imaging. 2016;43(11):1995–2004. https://doi.org/10.1007/s00259-016-3392-7. Epub 2016 Apr 28. PubMed PMID: 27121691.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Cristina Nanni .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Nanni, C. (2019). PET/CT with Standard Non-FDG Tracers in Multiple Myeloma. In: Nanni, C., Fanti, S., Zanoni, L. (eds) Molecular Imaging in Multiple Myeloma. Springer, Cham. https://doi.org/10.1007/978-3-030-19019-4_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-19019-4_7

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-19018-7

  • Online ISBN: 978-3-030-19019-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics