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Treatment and Prevention of Pain in Children and Adults with Burn Injuries

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Handbook of Burns Volume 1

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Abstract

The effective prevention and treatment of pain in children and adults after burn injuries requires intensive “multi-modal analgesia” starting within the first minutes following hospital admission. It is now considered inappropriate and unethical to perform elective painful procedures in children or adults without evidence-based treatments to avoid or minimize pain. Safe multi-modal, i.e., opioid-sparing, analgesia, may include one, several, or all of the following approaches in the effective treatment of pediatric or adult burn patients: pharmacology (e.g., simple analgesia and/or opioids and/or adjuvant analgesia), anesthetic interventions (e.g., neuroaxial analgesia, nerve blocks), rehabilitation (e.g., physical therapy, occupational therapy, sleep hygiene), psychology (e.g., cognitive behavioral therapy), and age-appropriate positioning and integrative (“non-pharmacological”) therapies, such as breathing techniques, self-hypnosis, and distraction.

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References

  1. Mendoza A, Santoyo FL, Agullo A, Fenandez-Canamaque JL, Vivo C. The management of pain associated with wound care in severe burn patients in Spain. Int J Burns Trauma. 2016;6(1):1–10.

    PubMed  PubMed Central  Google Scholar 

  2. Gallagher G, Rae CP, Kinsella J. Treatment of pain in severe burns. Am J Clin Dermatol. 2000;1(6):329–35.

    Article  CAS  PubMed  Google Scholar 

  3. Saxe G, Stoddard F, Courtney D, Cunningham K, Chawla N, Sheridan R, et al. Relationship between acute morphine and the course of PTSD in children with burns. J Am Acad Child Adolesc Psychiatry. 2001;40(8):915–21.

    Article  CAS  PubMed  Google Scholar 

  4. Saxe GN, Stoddard F, Hall E, Chawla N, Lopez C, Sheridan R, et al. Pathways to PTSD, part I: children with burns. Am J Psychiatry. 2005;162(7):1299–304.

    Article  PubMed  Google Scholar 

  5. Hall E, Saxe G, Stoddard F, Kaplow J, Koenen K, Chawla N, et al. Posttraumatic stress symptoms in parents of children with acute burns. J Pediatr Psychol. 2006;31(4):403–12.

    Article  PubMed  Google Scholar 

  6. Stoddard FJ Jr, Sorrentino EA, Ceranoglu TA, Saxe G, Murphy JM, Drake JE, et al. Preliminary evidence for the effects of morphine on posttraumatic stress disorder symptoms in one- to four-year-olds with burns. J Burn Care Res. 2009;30(5):836–43.

    Article  PubMed  Google Scholar 

  7. Rizzone LP, Stoddard FJ, Murphy JM, Kruger LJ. Posttraumatic stress disorder in mothers of children and adolescents with burns. J Burn Care Rehabil. 1994;15(2):158–63.

    Article  CAS  PubMed  Google Scholar 

  8. Brown NJ, Kimble RM, Gramotnev G, Rodger S, Cuttle L. Predictors of re-epithelialization in pediatric burn. Burns. 2014;40(4):751–8.

    Article  PubMed  Google Scholar 

  9. Thomas SH, Shewakramani S. Prehospital trauma analgesia. J Emerg Med. 2008;35(1):47–57.

    Article  PubMed  Google Scholar 

  10. Thomas SH, Silen W. Effect on diagnostic efficiency of analgesia for undifferentiated abdominal pain. Br J Surg. 2003;90(1):5–9.

    Article  CAS  PubMed  Google Scholar 

  11. Patterson DR, Hofland HW, Espey K, Sharar S. Nursing Committee of the International Society for Burn I. Pain management. Burns. 2004;30(8):A10–5.

    Article  PubMed  Google Scholar 

  12. Friedrichsdorf SJ, Postier A, Eull D, Weidner C, Foster L, Gilbert M, et al. Pain outcomes in a US Children’s Hospital: a prospective cross-sectional survey. Hosp Pediatr. 2015;5(1):18–26.

    Article  PubMed  Google Scholar 

  13. Taylor EM, Boyer K, Campbell FA. Pain in hospitalized children: a prospective cross-sectional survey of pain prevalence, intensity, assessment and management in a Canadian pediatric teaching hospital. Pain Res Manag. 2008;13(1):25–32.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Zhu LM, Stinson J, Palozzi L, Weingarten K, Hogan ME, Duong S, et al. Improvements in pain outcomes in a Canadian Pediatric Teaching Hospital following implementation of a multifaceted knowledge translation initiative. Pain Res Manag. 2012;17(3):173–9.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Stevens BJ, Harrison D, Rashotte J, Yamada J, Abbott LK, Coburn G, et al. Pain assessment and intensity in hospitalized children in Canada. J Pain. 2012;13(9):857–65.

    Article  PubMed  Google Scholar 

  16. Briggs M, Ferris FD, Glynn C, Harding K, Hofman D, Hollinworth H, et al. Assessing pain at wound dressing-related procedures. Nurs Times. 2004;100(41):56–7.

    PubMed  Google Scholar 

  17. Gamst-Jensen H, Vedel PN, Lindberg-Larsen VO, Egerod I. Acute pain management in burn patients: appraisal and thematic analysis of four clinical guidelines. Burns. 2014;40(8):1463–9.

    Article  PubMed  Google Scholar 

  18. Friedrichsdorf SJ. Prevention and treatment of pain in hospitalized infants, children, and teenagers: from myths and morphine to multimodal analgesia. Pain 2016: Refresher Courses 16th World Congress on Pain. Washington, D.C. IASP Press: International Association for the Study of Pain; 2016. p. 309–19.

    Google Scholar 

  19. Minnesota CsHaCo. Children’s Comfort Promise 2017. http://www.childrensMN.org/comfortpromise.

  20. Friedrichsdorf SJ, Eull D, Weidner CA. Children’s Comfort Promise: how can we do everything possible to prevent and treat pain in children using quality improvement strategies? (Commentary). Pediatr Pain Lett. 2016;18(3):26–30.

    Google Scholar 

  21. Council CsMYA. The Comfort Promise: The Youth Advisory Council highlights children’s unique approach to help patients prevent and treat pain. 2016. https://vimeo.com/128990829.

  22. Taddio A, Riddell RP, Ipp M, Moss S, Baker S, Tolkin J, et al. Relative effectiveness of additive pain interventions during vaccination in infants. CMAJ. 2017;189(6):E227–34.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Lunoe MM, Drendel AL, Levas MN, Weisman SJ, Dasgupta M, Hoffmann RG, et al. A randomized clinical trial of jet-injected lidocaine to reduce venipuncture pain for young children. Ann Emerg Med. 2015;66(5):466–74.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Lunoe MM, Drendel AL, Brousseau DC. The use of the needle-free jet injection system with buffered lidocaine device does not change intravenous placement success in children in the emergency department. Acad Emerg Med. 2015;22(4):447–51.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Stevens B, Yamada J, Ohlsson A, Haliburton S, Shorkey A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2016;(7):CD001069.

    Google Scholar 

  26. Gao H, Gao H, Xu G, Li M, Du S, Li F, et al. Efficacy and safety of repeated oral sucrose for repeated procedural pain in neonates: a systematic review. Int J Nurs Stud. 2016;62:118–25.

    Article  PubMed  Google Scholar 

  27. Shah PS, Herbozo C, Aliwalas LL, Shah VS. Breastfeeding or breast milk for procedural pain in neonates. Cochrane Database Syst Rev. 2012;(12):CD004950.

    Google Scholar 

  28. Nursing CsBStBrtatUoOsSo. Be Sweet to Babies. 2014. http://www.cheo.on.ca/en/BeSweet2Babies.

  29. Karlson K, Darcy L, Enskär K. The use of restraint is never supportive (poster). Nordic Society of Pediatric Hematology/Oncology (NOPHO) 34th Annual Meeting 2016 and 11th Biannual Meeting of Nordic Society of Pediatric Oncology Nurses (NOBOS); May 27–31, 2016; Reykjavik, Iceland 2016.

    Google Scholar 

  30. Uman LS, Birnie KA, Noel M, Parker JA, Chambers CT, McGrath PJ, et al. Psychological interventions for needle-related procedural pain and distress in children and adolescents. Cochrane Database Syst Rev. 2013;(10):CD005179.

    Google Scholar 

  31. (IASP) IAftSoP. IASP taxonomy. https://www.iasp-pain.org/Taxonomy.

  32. Portilla AS, Bravo GL, Miraval FK, Villamar MF, Schneider JC, Ryan CM, et al. A feasibility study assessing cortical plasticity in chronic neuropathic pain following burn injury. J Burn Care Res. 2013;34(1):e48–52.

    Article  PubMed  Google Scholar 

  33. Bronson M. Psychological and emotional impact of a burn injury. The Phoenix Society for Burn Survivors. 2014. https://www.phoenix-society.org/resources/entry/psychological-and-emotional-impact.

  34. Dauber A, Osgood PF, Breslau AJ, Vernon HL, Carr DB. Chronic persistent pain after severe burns: a survey of 358 burn survivors. Pain Med. 2002;3(1):6–17.

    Article  PubMed  Google Scholar 

  35. Friedrichsdorf SJ, Giordano J, Desai-Dakoji K, Warmuth A, Schulz CA. Chronic pain in children and adolescents: diagnosis and treatment of primary pain disorders in head, abdomen, muscles and joints. Children (Basel). 2016;3(4):E42.

    Google Scholar 

  36. Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain—United States, 2016. MMWR Recomm Rep. 2016;65(1):1–49.

    Article  PubMed  Google Scholar 

  37. Sen IM, Sen RK. Regional anesthesia for lower limb burn wound debridements. Arch Trauma Res. 2012;1(3):135–6.

    PubMed  PubMed Central  Google Scholar 

  38. Cuignet O, Mbuyamba J, Pirson J. The long-term analgesic efficacy of a single-shot fascia iliaca compartment block in burn patients undergoing skin-grafting procedures. J Burn Care Rehabil. 2005;26(5):409–15.

    Article  CAS  PubMed  Google Scholar 

  39. Bussolin L, Busoni P, Giorgi L, Crescioli M, Messeri A. Tumescent local anesthesia for the surgical treatment of burns and postburn sequelae in pediatric patients. Anesthesiology. 2003;99(6):1371–5.

    Article  PubMed  Google Scholar 

  40. Hernandez JL, Savetamal A, Crombie RE, Cholewczynski W, Atweh N, Possenti P, et al. Use of continuous local anesthetic infusion in the management of postoperative split-thickness skin graft donor site pain. J Burn Care Res. 2013;34(4):e257–62.

    Article  PubMed  Google Scholar 

  41. Shank ES, Martyn JA, Donelan MB, Perrone A, Firth PG, Driscoll DN. Ultrasound-guided regional anesthesia for pediatric burn reconstructive surgery: a prospective study. J Burn Care Res. 2016;37(3):e213–7.

    Article  PubMed  Google Scholar 

  42. Cuignet O, Pirson J, Boughrouph J, Duville D. The efficacy of continuous fascia iliaca compartment block for pain management in burn patients undergoing skin grafting procedures. Anesth Analg. 2004;98(4):1077–81, table of contents.

    Article  PubMed  Google Scholar 

  43. Bittner EA, Shank E, Woodson L, Martyn JA. Acute and perioperative care of the burn-injured patient. Anesthesiology. 2015;122(2):448–64.

    Article  PubMed  Google Scholar 

  44. Rork JF, Berde CB, Goldstein RD. Regional anesthesia approaches to pain management in pediatric palliative care: a review of current knowledge. J Pain Symptom Manage. 2013;46(6):859–73.

    Article  PubMed  Google Scholar 

  45. Burns DA. Using regional anesthesia to manage pediatric acute pain. In: 10th Pediatric Pain Master’s Class; Minneapolis, MN 2017.

    Google Scholar 

  46. Blanchet B, Jullien V, Vinsonneau C, Tod M. Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients. Clin Pharmacokinet. 2008;47(10):635–54.

    Article  CAS  PubMed  Google Scholar 

  47. Heubi JE, Barbacci MB, Zimmerman HJ. Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children. J Pediatr. 1998;132(1):22–7.

    Article  CAS  PubMed  Google Scholar 

  48. Moore RA, Derry S, Straube S, Ireson-Paine J, Wiffen PJ. Faster, higher, stronger? Evidence for formulation and efficacy for ibuprofen in acute pain. Pain. 2014;155(1):14–21.

    Article  CAS  PubMed  Google Scholar 

  49. Peloso PM. Faster, higher, stronger: to the gold medal podium? Pain. 2014;155(1):4–5.

    Article  PubMed  Google Scholar 

  50. Drake R, Longworth J, Collins JJ. Opioid rotation in children with cancer. J Palliat Med. 2004;7(3):419–22.

    Article  PubMed  Google Scholar 

  51. Friedrichsdorf SJ. From Coke to Pepsi to Mountain Dew? Rotating opioids in advanced pediatric palliative care. AAHPM Winter Quart Clin Pearls. 2014;15(4):8–9.

    Google Scholar 

  52. Jacobsen J. Topical opioids for pain #185. J Palliat Med. 2009;12(4):380–1.

    Article  PubMed  Google Scholar 

  53. McPherson C, Haslam M, Pineda R, Rogers C, Neil JJ, Inder TE. Brain injury and development in preterm infants exposed to fentanyl. Ann Pharmacother. 2015;49(12):1291–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Steinhorn R, McPherson C, Anderson PJ, Neil J, Doyle LW, Inder T. Neonatal morphine exposure in very preterm infants-cerebral development and outcomes. J Pediatr. 2015;166(5):1200–7.. e4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. MacGregor R, Evans D, Sugden D, Gaussen T, Levene M. Outcome at 5-6 years of prematurely born children who received morphine as neonates. Arch Dis Child Fetal Neonatal Ed. 1998;79(1):F40–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. de Graaf J, van Lingen RA, Valkenburg AJ, Weisglas-Kuperus N, Groot Jebbink L, Wijnberg-Williams B, et al. Does neonatal morphine use affect neuropsychological outcomes at 8 to 9 years of age? Pain. 2013;154(3):449–58.

    Article  PubMed  CAS  Google Scholar 

  57. Borland ML, Bergesio R, Pascoe EM, Turner S, Woodger S. Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study. Burns. 2005;31(7):831–7.

    Article  CAS  PubMed  Google Scholar 

  58. Cherny NJ, Chang V, Frager G, Ingham JM, Tiseo PJ, Popp B, et al. Opioid pharmacotherapy in the management of cancer pain: a survey of strategies used by pain physicians for the selection of analgesic drugs and routes of administration. Cancer. 1995;76(7):1283–93.

    Article  CAS  PubMed  Google Scholar 

  59. Goodarzi M. Comparison of epidural morphine, hydromorphone and fentanyl for postoperative pain control in children undergoing orthopaedic surgery. Paediatr Anaesth. 1999;9(5):419–22.

    Article  CAS  PubMed  Google Scholar 

  60. Babul N, Darke AC. Putative role of hydromorphone metabolites in myoclonus. Pain. 1992;51(2):260–1.

    Article  CAS  PubMed  Google Scholar 

  61. Davis M, Wilcock A. Modified release opioids. Europ J Palliative Care. 2001;(8):142–6.

    Google Scholar 

  62. Babul N, Darke AC, Hagen N. Hydromorphone metabolite accumulation in renal failure. J Pain Symptom Manage. 1995;10(3):184–6.

    Article  CAS  PubMed  Google Scholar 

  63. Nielsen CK, Ross FB, Lotfipour S, Saini KS, Edwards SR, Smith MT. Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain. 2007;132(3):289–300.

    Article  CAS  PubMed  Google Scholar 

  64. Kalso E. How different is oxycodone from morphine? Pain. 2007;132(3):227–8.

    Article  PubMed  Google Scholar 

  65. Kaiko R, Benziger D, Cheng C, Hou Y, Grandy R. Clinical pharmacokinetics of controlled-release oxycodone in renal impairment. Clinical Pharm Ther. 1996;59(1):130.

    Article  Google Scholar 

  66. Fife A, Postier A, Flood A, Friedrichsdorf SJ. Methadone conversion in infants and children: retrospective cohort study of 199 pediatric inpatients. J Opioid Manag. 2016;12(2):123–30.

    Article  PubMed  Google Scholar 

  67. Friedrichsdorf S, Kang T. The management of pain in children with life-limiting illnesses. Pediatr Clin North Am. 2007;54(5):645–72.

    Article  PubMed  Google Scholar 

  68. Altier N, Dion D, Boulanger A, Choiniere M. Successful use of methadone in the treatment of chronic neuropathic pain arising from burn injuries: a case-study. Burns. 2001;27(7):771–5.

    Article  CAS  PubMed  Google Scholar 

  69. Jones GM, Porter K, Coffey R, Miller SF, Cook CH, Whitmill ML, et al. Impact of early methadone initiation in critically injured burn patients: a pilot study. J Burn Care Res. 2013;34(3):342–8.

    Article  PubMed  Google Scholar 

  70. Williams PI, Sarginson RE, Ratcliffe JM. Use of methadone in the morphine-tolerant burned paediatric patient. Br J Anaesth. 1998;80(1):92–5.

    Article  CAS  PubMed  Google Scholar 

  71. Siddappa R, Fletcher JE, Heard AM, Kielma D, Cimino M, Heard CM. Methadone dosage for prevention of opioid withdrawal in children. Paediatr Anaesth. 2003;13(9):805–10.

    Article  PubMed  Google Scholar 

  72. Anghelescu DL, Faughnan LG, Hankins GM, Ward DA, Oakes LL. Methadone use in children and young adults at a cancer center: a retrospective study. J Opioid Manag. 2011;7(5):353–61.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Davies D, DeVlaming D, Haines C. Methadone analgesia for children with advanced cancer. Pediatr Blood Cancer. 2008;51(3):393–7.

    Article  PubMed  Google Scholar 

  74. Gudin JA. The changing landscape of opioid prescribing: long-acting and extended-release opioid class-wide Risk Evaluation and Mitigation Strategy. Ther Clin Risk Manag. 2012;8:209–17.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Mercadante S, Caraceni A. Conversion ratios for opioid switching in the treatment of cancer pain: a systematic review. Palliat Med. 2011;25(5):504–15.

    Article  PubMed  Google Scholar 

  76. Pereira J, Lawlor P, Vigano A, Dorgan M, Bruera E. Equianalgesic dose ratios for opioids. a critical review and proposals for long-term dosing. J Pain Symptom Manage. 2001;22(2):672–87. Review. PMID: 11495714.

    Article  CAS  PubMed  Google Scholar 

  77. Toombs JD, Kral LA. Methadone treatment for pain states. Am Fam Physician. 2005;71(7):1353–8.

    PubMed  Google Scholar 

  78. von Gunten C. Methadone: starting dosing information no. 86. J Palliat Med. 2004;7(2):304–5.

    Article  Google Scholar 

  79. Jacox A, Carr D, Payne R. New clinical-practice guidelines for the management of pain in patients with cancer. N Engl J Med. 1994;330(9):651–5.

    Article  CAS  PubMed  Google Scholar 

  80. Patanwala AE, Duby J, Waters D, Erstad BL. Opioid conversions in acute care. Ann Pharmacother. 2007;41(2):255–66.

    Article  CAS  PubMed  Google Scholar 

  81. Moryl N, Santiago-Palma J, Kornick C, Derby S. Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain. Pain. 2002;96(3):325–8.

    Article  CAS  PubMed  Google Scholar 

  82. Johnson P, Boyles K, Miller J. Selection of the initial methadone regimen for the management of iatrogenic opioid abstinence syndrome in critically ill children. Pharmacotherapy. 2012;32(2):148–57.

    Article  CAS  PubMed  Google Scholar 

  83. Walker P, Palla S, Pei B-L, Kaur G, Zhang K, Hanohano J, et al. Switching from methadone to a different opioid: what is the equianalgesic dose ratio? J Palliat Med. 2008;11(8):1103–8.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Weschules DJ, Bain KT. A systematic review of opioid conversion ratios used with methadone for the treatment of pain. Pain Med. 2008;9(5):595–612.

    Article  PubMed  Google Scholar 

  85. Gazelle G, Fine PG. Methadone for the treatment of pain #75. J Palliat Med. 2003;6(4):620–1.

    Article  CAS  PubMed  Google Scholar 

  86. ROXANE LABORATORIES IC, OH 43216. DOLOPHINE® HYDROCHLORIDE CII (Methadone Hydrochloride Tablets, USP) [cited 2015 June 19, 2015]. http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/006134s028lbl.pdf.

  87. Schechter NL. Functional pain: time for a new name. JAMA Pediatr. 2014;168(8):693–4.

    Article  PubMed  Google Scholar 

  88. Chapman CR, Lipschitz DL, Angst MS, Chou R, Denisco RC, Donaldson GW, et al. Opioid pharmacotherapy for chronic non-cancer pain in the United States: a research guideline for developing an evidence-base. J Pain. 2010;11(9):807–29.

    Article  PubMed  Google Scholar 

  89. Chapman CR, Davis J, Donaldson GW, Naylor J, Winchester D. Postoperative pain trajectories in chronic pain patients undergoing surgery: the effects of chronic opioid pharmacotherapy on acute pain. J Pain. 2011;12(12):1240–6.

    Article  CAS  PubMed  Google Scholar 

  90. Elliott JA, Horton E, Fibuch EE. The endocrine effects of long-term oral opioid therapy: a case report and review of the literature. J Opioid Manag. 2011;7(2):145–54.

    Article  PubMed  Google Scholar 

  91. Chaparro LE, Furlan AD, Deshpande A, Mailis-Gagnon A, Atlas S, Turk DC. Opioids compared with placebo or other treatments for chronic low back pain: an update of the Cochrane Review. Spine (Phila Pa 1976). 2014;39(7):556–63.

    Article  Google Scholar 

  92. Ashworth J, Green DJ, Dunn KM, Jordan KP. Opioid use among low back pain patients in primary care: is opioid prescription associated with disability at 6-month follow-up? Pain. 2013;154(7):1038–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Scherrer JF, Salas J, Lustman PJ, Burge S, Schneider FD. Residency Research Network of Texas I. Change in opioid dose and change in depression in a longitudinal primary care patient cohort. Pain. 2015;156(2):348–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Chen L, Vo T, Seefeld L, Malarick C, Houghton M, Ahmed S, et al. Lack of correlation between opioid dose adjustment and pain score change in a group of chronic pain patients. J Pain. 2013;14(4):384–92.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Friedrichsdorf SJ, Nugent AP. Management of neuropathic pain in children with cancer. Curr Opin Support Palliat Care. 2013;7(2):131–8.

    Article  PubMed  Google Scholar 

  96. Vidor LP, Torres IL, Custodio de Souza IC, Fregni F, Caumo W. Analgesic and sedative effects of melatonin in temporomandibular disorders: a double-blind, randomized, parallel-group, placebo-controlled study. J Pain Symptom Manage. 2013;46(3):422–32.

    Article  PubMed  CAS  Google Scholar 

  97. Schwertner A, Conceicao Dos Santos CC, Costa GD, Deitos A, de Souza A, de Souza IC, et al. Efficacy of melatonin in the treatment of endometriosis: a phase II, randomized, double-blind, placebo-controlled trial. Pain. 2013;154(6):874–81.

    Article  CAS  PubMed  Google Scholar 

  98. Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Hauer JM, Solodiuk JC. Gabapentin for management of recurrent pain in 22 nonverbal children with severe neurological impairment: a retrospective analysis. J Palliat Med. 2015;18(5):453–6.

    Article  PubMed  Google Scholar 

  100. Edwards L, DeMeo S, Hornik CD, Cotten CM, Smith PB, Pizoli C, et al. Gabapentin use in the neonatal intensive care unit. J Pediatr. 2016;169:310–2.

    Article  CAS  PubMed  Google Scholar 

  101. Derry S, Wiffen PJ, Moore RA, Quinlan J. Topical lidocaine for neuropathic pain in adults. Cochrane Database Syst Rev. 2014;(7):CD010958.

    Google Scholar 

  102. Bahar RJ, Collins BS, Steinmetz B, Ament ME. Double-blind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents. J Pediatr. 2008;152(5):685–9.

    Article  CAS  PubMed  Google Scholar 

  103. Saps M, Youssef N, Miranda A, Nurko S, Hyman P, Cocjin J, et al. Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. Gastroenterology. 2009;137(4):1261–9.

    Article  CAS  PubMed  Google Scholar 

  104. Assouline B, Tramer MR, Kreienbuhl L, Elia N. Benefit and harm of adding ketamine to an opioid in a patient-controlled analgesia device for the control of postoperative pain: systematic review and meta-analyses of randomized controlled trials with trial sequential analyses. Pain. 2016;157(12):2854–64.

    Article  CAS  PubMed  Google Scholar 

  105. Finkel J, Pestieau S, Quezado Z. Ketamine as an adjuvant for treatment of cancer pain in children and adolescents. J Pain. 2007;8(6):515–21.

    Article  CAS  PubMed  Google Scholar 

  106. Norambuena C, Yanez J, Flores V, Puentes P, Carrasco P, Villena R. Oral ketamine and midazolam for pediatric burn patients: a prospective, randomized, double-blind study. J Pediatr Surg. 2013;48(3):629–34.

    Article  PubMed  Google Scholar 

  107. Peixoto RD, Hawley P. Intravenous lidocaine for cancer pain without electrocardiographic monitoring: a retrospective review. J Palliat Med. 2015;18(4):373–7.

    Article  PubMed  Google Scholar 

  108. Krane E, Leong M, Golianu B, Leong Y. Treatment of pediatric pain with nonconventional analgesics. In: Schechter N, Berde C, Yaster M, editors. Pain in infants, children, and adolescents. Philadelphia: Lippincott Williams & Wilkins; 2003. p. 225–40.

    Google Scholar 

  109. Wasiak J, Mahar PD, McGuinness SK, Spinks A, Danilla S, Cleland H, et al. Intravenous lidocaine for the treatment of background or procedural burn pain. Cochrane Database Syst Rev. 2014;(10):CD005622.

    Google Scholar 

  110. Ferrini R, Paice JA. How to initiate and monitor infusional lidocaine for severe and/or neuropathic pain. J Support Oncol. 2004;2(1):90–4.

    PubMed  Google Scholar 

  111. Brummett CM, Trivedi KA, Dubovoy AV, Berland DW. Dexmedetomidine as a novel therapeutic for postoperative pain in a patient treated with buprenorphine. J Opioid Manag. 2009;5(3):175–9.

    Article  PubMed  Google Scholar 

  112. Roberts SB, Wozencraft CP, Coyne PJ, Smith TJ. Dexmedetomidine as an adjuvant analgesic for intractable cancer pain. J Palliat Med. 2011;14(3):371–3.

    Article  PubMed  Google Scholar 

  113. O’Mara K, Gal P, Wimmer J, Ransom JL, Carlos RQ, Dimaguila MA, et al. Dexmedetomidine versus standard therapy with fentanyl for sedation in mechanically ventilated premature neonates. J Pediatr Pharmacol Ther. 2012;17(3):252–62.

    PubMed  PubMed Central  Google Scholar 

  114. Chrysostomou C, Schulman SR, Herrera Castellanos M, Cofer BE, Mitra S, da Rocha MG, et al. A phase II/III, multicenter, safety, efficacy, and pharmacokinetic study of dexmedetomidine in preterm and term neonates. J Pediatr. 2014;164(2):276–82 e1-3.

    Article  CAS  PubMed  Google Scholar 

  115. O’Neil T, Rodgers PE, Shultz C. Dexmedetomidine as adjuvant therapy for acute postoperative neuropathic pain crisis. J Palliat Med. 2014;17(10):1164–6.

    Article  PubMed  Google Scholar 

  116. Horvath R, Halbrooks EF, Overman DM, Friedrichsdorf SJ. Efficacy and safety of postoperative dexmedetomidine administration in infants and children undergoing cardiac surgery: a retrospective cohort study. J Pediatr Intensive Care. 2015;(3):138–45.

    Google Scholar 

  117. Aydogan MS, Korkmaz MF, Ozgul U, Erdogan MA, Yucel A, Karaman A, et al. Pain, fentanyl consumption, and delirium in adolescents after scoliosis surgery: dexmedetomidine vs midazolam. Paediatr Anaesth. 2013;23(5):446–52.

    Article  PubMed  Google Scholar 

  118. Funai Y, Pickering AE, Uta D, Nishikawa K, Mori T, Asada A, et al. Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control: an in vivo patch-clamp analysis of analgesic mechanisms. Pain. 2014;155(3):617–28.

    Article  CAS  PubMed  Google Scholar 

  119. Hill KP. Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: a clinical review. JAMA. 2015;313(24):2474–83.

    Article  CAS  PubMed  Google Scholar 

  120. Deshpande A, Mailis-Gagnon A, Zoheiry N, Lakha SF. Efficacy and adverse effects of medical marijuana for chronic noncancer pain: systematic review of randomized controlled trials. Can Fam Physician. 2015;61(8):e372–81.

    PubMed  PubMed Central  Google Scholar 

  121. Pediatrics AAo. Updated AAP policy opposes marijuana use, citing potential harms, lack of research. 2015. http://aapnews.aappublications.org/content/early/2015/01/26/aapnews.20150126-1.

  122. Casadio P, Fernandes C, Murray RM, Di Forti M. Cannabis use in young people: the risk for schizophrenia. Neurosci Biobehav Rev. 2011;35(8):1779–87.

    Article  PubMed  Google Scholar 

  123. Daling JR, Doody DR, Sun X, Trabert BL, Weiss NS, Chen C, et al. Association of marijuana use and the incidence of testicular germ cell tumors. Cancer. 2009;115(6):1215–23.

    Article  PubMed  Google Scholar 

  124. Trabert B, Sigurdson AJ, Sweeney AM, Strom SS, McGlynn KA. Marijuana use and testicular germ cell tumors. Cancer. 2011;117(4):848–53.

    Article  PubMed  Google Scholar 

  125. Lacson JC, Carroll JD, Tuazon E, Castelao EJ, Bernstein L, Cortessis VK. Population-based case-control study of recreational drug use and testis cancer risk confirms an association between marijuana use and nonseminoma risk. Cancer. 2012;118(21):5374–83.

    Article  CAS  PubMed  Google Scholar 

  126. Meier MH, Caspi A, Ambler A, Harrington H, Houts R, Keefe RS, et al. Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc Natl Acad Sci U S A. 2012;109(40):E2657–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  127. Moffitt TE, Meier MH, Caspi A, Poulton R. Reply to Rogeberg and Daly: no evidence that socioeconomic status or personality differences confound the association between cannabis use and IQ decline. Proc Natl Acad Sci U S A. 2013;110(11):E980–2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  128. Meier MH, Hall W, Caspi A, Belsky DW, Cerda M, Harrington HL, et al. Which adolescents develop persistent substance dependence in adulthood? Using population-representative longitudinal data to inform universal risk assessment. Psychol Med. 2016;46(4):877–89.

    Article  CAS  PubMed  Google Scholar 

  129. Tourtier JP, Raynaud L, Murat I, Gall O. Audit of protocols for treatment of paediatric burns in emergency departments in the Ile de France. Burns. 2010;36(8):1196–200.

    Article  PubMed  Google Scholar 

  130. Hockenberry MJ, McCarthy K, Taylor O, Scarberry M, Franklin Q, Louis CU, et al. Managing painful procedures in children with cancer. J Pediatr Hematol Oncol. 2011;33(2):119–27.

    Article  PubMed  Google Scholar 

  131. Pedersen RS, Bayat A, Steen NP, Jacobsson ML. Nitrous oxide provides safe and effective analgesia for minor paediatric procedures—a systematic review. Dan Med J. 2013;60(6):A4627.

    PubMed  Google Scholar 

  132. Tobias JD. Applications of nitrous oxide for procedural sedation in the pediatric population. Pediatr Emerg Care. 2013;29(2):245–65.

    Article  PubMed  Google Scholar 

  133. Friedrichsdorf SJ. Nitrous gas analgesia and sedation for lumbar punctures in children: has the time for practice change come? Pediatr Blood Cancer. 2017;64(11).

    Article  Google Scholar 

  134. Weisman SJ, Bernstein B, Schechter NL. Consequences of inadequate analgesia during painful procedures in children. Arch Pediatr Adolesc Med. 1998;152(2):147–9.

    Article  CAS  PubMed  Google Scholar 

  135. Anghelescu DL, Burgoyne LL, Faughnan LG, Hankins GM, Smeltzer MP, Pui CH. Prospective randomized crossover evaluation of three anesthetic regimens for painful procedures in children with cancer. J Pediatr. 2013;162(1):137–41.

    Article  CAS  PubMed  Google Scholar 

  136. Logan DE, Carpino EA, Chiang G, Condon M, Firn E, Gaughan VJ, et al. A day-hospital approach to treatment of pediatric complex regional pain syndrome: initial functional outcomes. Clin J Pain. 2012;28(9):766–74.

    Article  PubMed  Google Scholar 

  137. Eccleston C, Malleson PN, Clinch J, Connell H, Sourbut C. Chronic pain in adolescents: evaluation of a programme of interdisciplinary cognitive behaviour therapy. Arch Dis Child. 2003;88(10):881–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  138. Maynard CS, Amari A, Wieczorek B, Christensen JR, Slifer KJ. Interdisciplinary behavioral rehabilitation of pediatric pain-associated disability: retrospective review of an inpatient treatment protocol. J Pediatr Psychol. 2010;35(2):128–37.

    Article  PubMed  Google Scholar 

  139. Palermo TM, Scher MS. Treatment of functional impairment in severe somatoform pain disorder: a case example. J Pediatr Psychol. 2001;26(7):429–34.

    Article  CAS  PubMed  Google Scholar 

  140. Lynch-Jordan AM, Sil S, Peugh J, Cunningham N, Kashikar-Zuck S, Goldschneider KR. Differential changes in functional disability and pain intensity over the course of psychological treatment for children with chronic pain. Pain. 2014;155(10):1955–61.

    Article  PubMed  PubMed Central  Google Scholar 

  141. Sherry DD, Wallace CA, Kelley C, Kidder M, Sapp L. Short- and long-term outcomes of children with complex regional pain syndrome type I treated with exercise therapy. Clin J Pain. 1999;15(3):218–23.

    Article  CAS  PubMed  Google Scholar 

  142. Odell S, Logan DE. Pediatric pain management: the multidisciplinary approach. J Pain Res. 2013;6:785–90.

    Article  PubMed  PubMed Central  Google Scholar 

  143. Lee BH, Scharff L, Sethna NF, McCarthy CF, Scott-Sutherland J, Shea AM, et al. Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes. J Pediatr. 2002;141(1):135–40.

    Article  PubMed  Google Scholar 

  144. Wilson AC, Palermo TM. Physical activity and function in adolescents with chronic pain: a controlled study using actigraphy. J Pain. 2012;13(2):121–30.

    Article  PubMed  Google Scholar 

  145. Jerstad SJ, Boutelle KN, Ness KK, Stice E. Prospective reciprocal relations between physical activity and depression in female adolescents. J Consult Clin Psychol. 2010;78(2):268–72.

    Article  PubMed  PubMed Central  Google Scholar 

  146. Bussing A, Ostermann T, Ludtke R, Michalsen A. Effects of yoga interventions on pain and pain-associated disability: a meta-analysis. J Pain. 2012;13(1):1–9.

    Article  PubMed  Google Scholar 

  147. Evans S, Moieni M, Taub R, Subramanian SK, Tsao JC, Sternlieb B, et al. Iyengar yoga for young adults with rheumatoid arthritis: results from a mixed-methods pilot study. J Pain Symptom Manage. 2010;39(5):904–13.

    Article  PubMed  Google Scholar 

  148. Vas J, Santos-Rey K, Navarro-Pablo R, Modesto M, Aguilar I, Campos MA, et al. Acupuncture for fibromyalgia in primary care: a randomised controlled trial. Acupunct Med. 2016;34(4):257–66.

    Article  PubMed  Google Scholar 

  149. Verkamp EK, Flowers SR, Lynch-Jordan AM, Taylor J, Ting TV, Kashikar-Zuck S. A survey of conventional and complementary therapies used by youth with juvenile-onset fibromyalgia. Pain Manag Nurs. 2013;14(4):e244–50.

    Article  PubMed  Google Scholar 

  150. Friedrichsdorf S, Kuttner L, Westendorp K, McCarty R. Integrative pediatric palliative care. In: Culbert T, Olness K, editors. Integrative pediatrics. New York: Oxford University Press; 2010.

    Google Scholar 

  151. Kuttner L, Friedrichsdorf SJ. Hypnosis and palliative care. Therapeutic hypnosis with children and adolescents. 2nd ed. Bethel: Crown House Publishing Limited; 2013. p. 491–509.

    Google Scholar 

  152. Hunt K, Ernst E. The evidence-base for complementary medicine in children: a critical overview of systematic reviews. Arch Dis Child. 2011;96(8):769–76.

    Article  PubMed  Google Scholar 

  153. Evans S, Tsao JC, Zeltzer LK. Complementary and alternative medicine for acute procedural pain in children. Altern Ther Health Med. 2008;14(5):52–6.

    PubMed  Google Scholar 

  154. Richardson J, Smith JE, McCall G, Pilkington K. Hypnosis for procedure-related pain and distress in pediatric cancer patients: a systematic review of effectiveness and methodology related to hypnosis interventions. J Pain Symptom Manage. 2006;31(1):70–84.

    Article  PubMed  Google Scholar 

  155. Hemington KS, Coulombe MA. The periaqueductal gray and descending pain modulation: Why should we study them and what role do they play in chronic pain? J Neurophysiol. 2015;114(4):2080–3. https://doi.org/10.1152/jn.00998.2014.

    Article  PubMed  Google Scholar 

  156. Valet M, Sprenger T, Boecker H, Willoch F, Rummeny E, Conrad B, et al. Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain—an fMRI analysis. Pain. 2004;109(3):399–408.

    Article  PubMed  Google Scholar 

  157. Tracey I, Ploghaus A, Gati JS, Clare S, Smith S, Menon RS, et al. Imaging attentional modulation of pain in the periaqueductal gray in humans. J Neurosci. 2002;22(7):2748–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  158. Derbyshire SW, Osborn J. Modeling pain circuits: how imaging may modify perception. Neuroimaging Clin N Am. 2007;17(4):485–93, ix.

    Article  PubMed  Google Scholar 

  159. Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M, et al. The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. Sci Transl Med. 2011;3(70):70ra14.

    Article  PubMed  CAS  Google Scholar 

  160. Yu R, Gollub RL, Spaeth R, Napadow V, Wasan A, Kong J. Disrupted functional connectivity of the periaqueductal gray in chronic low back pain. Neuroimage Clin. 2014;6:100–8.

    Article  PubMed  PubMed Central  Google Scholar 

  161. Giordano J. The neurobiology of nociceptive and anti-nociceptive systems. Pain Physician. 2005;8(3):277–90.

    PubMed  Google Scholar 

  162. Tegethoff M, Belardi A, Stalujanis E, Meinlschmidt G. Comorbidity of mental disorders and chronic pain: chronology of onset in adolescents of a national representative cohort. J Pain. 2015;16(10):1054–64.

    Article  PubMed  Google Scholar 

  163. Cohen LL, Vowles KE, Eccleston C. The impact of adolescent chronic pain on functioning: disentangling the complex role of anxiety. J Pain. 2010;11(11):1039–46.

    Article  PubMed  Google Scholar 

  164. Palermo TM, Eccleston C, Lewandowski AS, Williams AC, Morley S. Randomized controlled trials of psychological therapies for management of chronic pain in children and adolescents: an updated meta-analytic review. Pain. 2010;148(3):387–97.

    Article  PubMed  Google Scholar 

  165. Eccleston C, Palermo TM, Williams AC, Lewandowski Holley A, Morley S, Fisher E, et al. Psychological therapies for the management of chronic and recurrent pain in children and adolescents. Cochrane Database Syst Rev. 2014;(5):CD003968.

    Google Scholar 

  166. Kashikar-Zuck S, Sil S, Lynch-Jordan AM, Ting TV, Peugh J, Schikler KN, et al. Changes in pain coping, catastrophizing, and coping efficacy after cognitive-behavioral therapy in children and adolescents with juvenile fibromyalgia. J Pain. 2013;14(5):492–501.

    Article  PubMed  PubMed Central  Google Scholar 

  167. Seminowicz DA, Shpaner M, Keaser ML, Krauthamer GM, Mantegna J, Dumas JA, et al. Cognitive-behavioral therapy increases prefrontal cortex gray matter in patients with chronic pain. J Pain. 2013;14(12):1573–84.

    Article  PubMed  Google Scholar 

  168. Stefan J. Friedrichsdorf, Donna Eull, Christian Weidner, Andrea Postier, A hospital-wide initiative to eliminate or reduce needle pain in children using lean methodology. PAIN Reports 3:e671

    Google Scholar 

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Authors and Affiliations

  1. Department of Pain Medicine, Palliative Care and Integrative Medicine, Children’s Hospitals and Clinics of Minnesota, University of Minnesota Medical School, Minneapolis, MN, USA

    Stefan J. Friedrichsdorf

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Editors and Affiliations

  1. Ross Tilley Burn Centre Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Marc G. Jeschke

  2. Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria

    Lars-Peter Kamolz

  3. Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

    Folke Sjöberg

  4. Department of Surgery, University of Texas Health Science Center, San Antonio, TX, USA

    Steven E. Wolf

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Friedrichsdorf, S.J. (2020). Treatment and Prevention of Pain in Children and Adults with Burn Injuries. In: Jeschke, M., Kamolz, LP., Sjöberg, F., Wolf, S. (eds) Handbook of Burns Volume 1. Springer, Cham. https://doi.org/10.1007/978-3-030-18940-2_25

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