Skip to main content

Vaccination in Patients with a Gastrointestinal Cancer

  • Chapter
  • First Online:
Book cover Textbook of Gastrointestinal Oncology
  • 828 Accesses

Abstract

Patients with cancer have an increased risk or severity of infection owing to the underlying disorder, administered chemotherapy, or radiation therapy. Vaccination of cancer patients reduces the burden and complications of vaccine-preventable diseases. Therefore, it is considered as a part of standard of care. However, the degree of immunosuppression and timing of vaccination may have an impact on the protective immune response to immunization. In this chapter, current vaccination strategies for adults with solid cancer, including gastrointestinal cancers, are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Decker W, Safdar A. Prophylactic vaccination of cancer patients and hematopoietic stem cell transplant recipients. In: Safdar A, editor. Principles and practice of cancer infectious diseases, current clinical oncology. Totowa: Humana Press, Springer Science+Business Media, LLC; 2011. p. 561–71.

    Chapter  Google Scholar 

  2. Burroughs M, Moscona A. Immunization of pediatric solid organ transplant candidates and recipients. Clin Infect Dis. 2000;30:857–69.

    Article  CAS  PubMed  Google Scholar 

  3. Sommer AL, Wachel BK, Smith JA. Evaluation of vaccine dosing in patients with solid tumors receiving myelosuppressive chemotherapy. J Oncol Pharm Pract. 2006;12:143–54.

    Article  CAS  PubMed  Google Scholar 

  4. Cohen JI. Strategies for herpes zoster vaccination of immunocompromised patients. J Infect Dis. 2008;197(Suppl 2):S237–41.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Kunisaki KM, Janoff EN. Influenza in immunosuppressed populations: a review of infection frequency, morbidity, mortality, and vaccine responses. Lancet Infect Dis. 2009;9:493–504.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Hibberd PL. Immunizations in patients with cancer. http://www.uptodate.com/contents/immunizations-in-patients-with-cancer. Accessed 31 Jan 2018.

  7. Rubin LG, Levin MJ, Ljungman P, Davies EG, Avery R, Tomblyn M, Bousvaros A, Dhanireddy S, Sung L, Keyserling H, Kang I, Infectious Diseases Society of America. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis. 2014;58:309–18.

    Article  PubMed  Google Scholar 

  8. Heijstek MW, Ott de Bruin LM, Bijl M, Borrow R, van der Klis F, Koné-Paut I, Fasth A, Minden K, Ravelli A, Abinun M, Pileggi GS, Borte M, Wulffraat NM, EULAR. EULAR recommendations for vaccination in paediatric patients with rheumatic diseases. Ann Rheum Dis. 2011;70:1704–12.

    Article  CAS  PubMed  Google Scholar 

  9. National Center for Immunization and Respiratory Diseases. General recommendations on immunization --- recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011;60:1–64. Erratum in: MMWR Recomm Rep 2011; 60: 993.

    Google Scholar 

  10. Kim DK, Bridges CB, Harriman KH, Advisory Committee on Immunization Practices (ACIP), ACIP Adult Immunization Work Group. Advisory Committee on Immunization Practices Recommended Immunization Schedule for adults aged 19 years or older - United States, 2016. MMWR Morb Mortal Wkly Rep. 2016;65:88–90.

    Article  PubMed  Google Scholar 

  11. Couch RB, Englund JA, Whimbey E. Respiratory viral infections in immunocompetent and immunocompromised persons. Am J Med. 1997;102:2–9. discussion 25-6.

    Article  CAS  PubMed  Google Scholar 

  12. Elting LS, Whimbey E, Lo W, Couch R, Andreeff M, Bodey GP. Epidemiology of influenza A virus infection in patients with acute or chronic leukemia. Support Care Cancer. 1995;3:198–202.

    Article  CAS  PubMed  Google Scholar 

  13. Ljungman P. Respiratory virus infections in stem cell transplant patients: the European experience. Biol Blood Marrow Transplant. 2001;7(Suppl):5S–7S.

    Article  PubMed  Google Scholar 

  14. Ljungman P. Respiratory virus infections in bone marrow transplant recipients: the European perspective. Am J Med. 1997;102:44–7.

    Article  CAS  PubMed  Google Scholar 

  15. Nichols WG, Guthrie KA, Corey L, Boeckh M. Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy. Clin Infect Dis. 2004;39:1300–6.

    Article  PubMed  Google Scholar 

  16. Gribabis DA, Panayiotidis P, Boussiotis VA, Hannoun C, Pangalis GA. Influenza virus vaccine in B-cell chronic lymphocytic leukaemia patients. Acta Haematol. 1994;91:115–8.

    Article  CAS  PubMed  Google Scholar 

  17. Anderson H, Petrie K, Berrisford C, Charlett A, Thatcher N, Zambon AM. Seroconversion after influenza vaccination in patients with lung cancer. Br J Cancer. 1999;80:219–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Brydak LB, Całbecka M. Immunogenicity of influenza vaccine in patients with hemato-oncological disorders. Leuk Lymphoma. 1999;32:369–74.

    Article  CAS  PubMed  Google Scholar 

  19. Beck CR, BC MK, Hashim AB, Harris RC, University of Nottingham Influenza and the ImmunoCompromised (UNIIC) Study Group, Nguyen-Van-Tam JS. Influenza vaccination for immunocompromised patients: systematic review and meta-analysis by etiology. J Infect Dis. 2012;206:1250–9.

    Article  PubMed  Google Scholar 

  20. Brydak LB, Guzy J, Starzyk J, Machała M, Góźdź SS. Humoral immune response after vaccination against influenza in patients with breast cancer. Support Care Cancer. 2001;9:65–8.

    Article  CAS  PubMed  Google Scholar 

  21. Ganz PA, Shanley JD, Cherry JD. Responses of patients with neoplastic diseases to influenza virus vaccine. Cancer. 1978;42:2244–7.

    Article  CAS  PubMed  Google Scholar 

  22. Nordøy T, Aaberge IS, Husebekk A, Samdal HH, Steinert S, Melby H, Kolstad A. Cancer patients undergoing chemotherapy show adequate serological response to vaccinations against influenza virus and Streptococcus pneumoniae. Med Oncol. 2002;19:71–8.

    Article  PubMed  Google Scholar 

  23. Ortbals DW, Liebhaber H, Presant CA, Van Amburg AL 3rd, Lee JY. Influenza immunization of adult patients with malignant diseases. Ann Intern Med. 1977;87:552–7.

    Article  CAS  PubMed  Google Scholar 

  24. Molrine DC, George S, Tarbell N, Mauch P, Diller L, Neuberg D, Shamberger RC, Anderson EL, Phillips NR, Kinsella K, Ambrosino DM. Antibody responses to polysaccharide and polysaccharide-conjugate vaccines after treatment of Hodgkin disease. Ann Intern Med. 1995;123:828–34.

    Article  CAS  PubMed  Google Scholar 

  25. Robertson JD, Nagesh K, Jowitt SN, Dougal M, Anderson H, Mutton K, Zambon M, Scarffe JH. Immunogenicity of vaccination against influenza, Streptococcus pneumoniae and Haemophilus influenzae type B in patients with multiple myeloma. Br J Cancer. 2000;82:1261–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Levine AM, Overturf GD, Field RF, Holdorf D, Paganini-Hill A, Feinstein DI. Use and efficacy of pneumococcal vaccine in patients with Hodgkin disease. Blood. 1979;54:1171–5.

    CAS  PubMed  Google Scholar 

  27. Hartkamp A, Mulder AH, Rijkers GT, van Velzen-Blad H, Biesma DH. Antibody responses to pneumococcal and haemophilus vaccinations in patients with B-cell chronic lymphocytic leukaemia. Vaccine. 2001;19:1671–7.

    Article  CAS  PubMed  Google Scholar 

  28. Siber GR, Weitzman SA, Aisenberg AC. Antibody response of patients with Hodgkin’s disease to protein and polysaccharide antigens. Rev Infect Dis. 1981;3(Suppl):S144–59.

    Article  PubMed  Google Scholar 

  29. Siber GR, Gorham C, Martin P, Corkery JC, Schiffman G. Antibody response to pretreatment immunization and post-treatment boosting with bacterial polysaccharide vaccines in patients with Hodgkin’s disease. Ann Intern Med. 1986;104:467–75.

    Article  CAS  PubMed  Google Scholar 

  30. Feldman S, Gigliotti F, Shenep JL, Roberson PK, Lott L. Risk of Haemophilus influenzae type b disease in children with cancer and response of immunocompromised leukemic children to a conjugate vaccine. J Infect Dis. 1990;161:926–31.

    Article  CAS  PubMed  Google Scholar 

  31. Ek T, Mellander L, Hahn-Zoric M, Abrahamsson J. Intensive treatment for childhood acute lymphoblastic leukemia reduces immune responses to diphtheria, tetanus, and Haemophilus influenzae type b. J Pediatr Hematol Oncol. 2004;26:727–34.

    Article  PubMed  Google Scholar 

  32. Rusthoven JJ, Ahlgren P, Elhakim T, Pinfold P, Reid J, Stewart L, Feld R. Varicella-zoster infection in adult cancer patients. A population study. Arch Intern Med. 1988;148:1561–6.

    Article  CAS  PubMed  Google Scholar 

  33. Kaplan LJ, Daum RS, Smaron M, McCarthy CA. Severe measles in immunocompromised patients. JAMA. 1992;267:1237–41.

    Article  CAS  PubMed  Google Scholar 

  34. Mast EE, Weinbaum CM, Fiore AE, Alter MJ, Bell BP, Finelli L, Rodewald LE, Douglas JM Jr, Janssen RS, Ward JW, Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) Part II: immunization of adults. MMWR Recomm Rep. 2006;55(RR-16):1–33. quiz CE1-4.

    PubMed  Google Scholar 

  35. Hovi L, Valle M, Siimes MA, Jalanko H, Saarinen UM. Impaired response to hepatitis B vaccine in children receiving anticancer chemotherapy. Pediatr Infect Dis J. 1995;14:931–5.

    Article  CAS  PubMed  Google Scholar 

  36. Goyal S, Pai SK, Kelkar R, Advani SH. Hepatitis B vaccination in acute lymphoblastic leukemia. Leuk Res. 1998;22:193–5.

    Article  CAS  PubMed  Google Scholar 

  37. Rosen HR, Stierer M, Wolf HM, Eibl MM. Impaired primary antibody responses after vaccination against hepatitis B in patients with breast cancer. Breast Cancer Res Treat. 1992;23:233–40.

    Article  CAS  PubMed  Google Scholar 

  38. Weitberg AB, Weitzman SA, Watkins E, Hinkle C, O’Rourke S, Dienstag JL. Immunogenicity of hepatitis B vaccine in oncology patients receiving chemotherapy. J Clin Oncol. 1985;3:718–22.

    Article  CAS  PubMed  Google Scholar 

  39. Hamarström V, Pauksen K, Svensson H, Oberg G, Paul C, Ljungman P. Tetanus immunity in patients with hematological malignancies. Support Care Cancer. 1998;6:469–72.

    Article  PubMed  Google Scholar 

  40. van der Does-van den Berg A, Hermans J, Nagel J, van Steenis G. Immunity to diphtheria, pertussis, tetanus, and poliomyelitis in children with acute lymphocytic leukemia after cessation of chemotherapy. Pediatrics. 1981;67:222–9.

    PubMed  Google Scholar 

  41. Markowitz LE, Dunne EF, Saraiya M, Lawson HW, Chesson H, Unger ER, Centers for Disease Control and Prevention (CDC), Advisory Committee on Immunization Practices (ACIP). Quadrivalent human papillomavirus vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2007;56(RR-2):1–24.

    PubMed  Google Scholar 

  42. http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/polio.pdf. Accessed 31 Jan 2018.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Murat Akova .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Alp, Ş., Akova, M. (2019). Vaccination in Patients with a Gastrointestinal Cancer. In: Yalcin, S., Philip, P. (eds) Textbook of Gastrointestinal Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-18890-0_37

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-18890-0_37

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-18888-7

  • Online ISBN: 978-3-030-18890-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics