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Basal Ganglio-thalamo-cortico-spino-muscular Model of Parkinson’s Disease Bradykinesia

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Part of the book series: Springer Series in Cognitive and Neural Systems ((SSCNS,volume 13))

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Abstract

Bradykinesia is the cardinal symptom of Parkinson’s disease (PD) related to slowness of movement. The causes of PD bradykinesia are not known largely, because there are multiple brain areas and pathways involved from the neuronal degeneration site (dopamine (DA) neurons in substantia nigra pars compacta (SNc) and ventral tegmental area (VTA)) to the muscles. A neurocomputational model of basal ganglio-thalamo-cortico-spino-muscular dynamics with dopamine of PD bradykinesia is presented as a unified theoretical framework capable of producing a wealth of neuronal, electromyographic, and behavioral movement empirical findings reported in parkinsonian human and animal brain studies. The model attempts to uncover how information is processed in the affected brain areas, what role does DA play, and what are the biophysical mechanisms giving rise to the observed slowness of movement in PD bradykinesia.

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Authors and Affiliations

  1. School of Computer Science, University of Lincoln, Lincoln, UK

    Vassilis Cutsuridis

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Correspondence to Vassilis Cutsuridis .

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  1. School of Computer Science, University of Lincoln, Lincoln, UK

    Vassilis Cutsuridis

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Cutsuridis, V. (2019). Basal Ganglio-thalamo-cortico-spino-muscular Model of Parkinson’s Disease Bradykinesia. In: Cutsuridis, V. (eds) Multiscale Models of Brain Disorders. Springer Series in Cognitive and Neural Systems, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-18830-6_4

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