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Shaping Brain Rhythms: Dynamic and Control-Theoretic Perspectives on Periodic Brain Stimulation for Treatment of Neurological Disorders

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Book cover Multiscale Models of Brain Disorders

Part of the book series: Springer Series in Cognitive and Neural Systems ((SSCNS,volume 13))

Abstract

Rhythmic, collective activity is a fundamental feature of neural systems. As a result of this, many of the challenges and opportunities involved in developing clinical tools from basic neuroscience knowledge come down to questions about control of dynamic, oscillatory networks. In this chapter we review a range of experimental and theoretical work on control of neural oscillations, in healthy brains and in relation to various clinical conditions. We highlight the main types of qualitative system behaviour that can result from application of periodic stimulation and present a simple case study on this using a mathematical model of rhythmogenesis in thalamocortical circuits. The concepts discussed here may, we hope, help provide some guidelines and principles for the development of future generations of more physiologically and dynamically informed brain stimulation techniques, paradigms, and researchers.

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Author information

Authors and Affiliations

  1. Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada

    John D. Griffiths

  2. Department of Psychiatry, University of Toronto, Toronto, ON, Canada

    John D. Griffiths

  3. Krembil Research Institute, University Health Network, Toronto, ON, Canada

    Jérémie R. Lefebvre

  4. Department of Mathematics, University of Toronto, Toronto, ON, Canada

    Jérémie R. Lefebvre

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  1. John D. Griffiths
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  2. Jérémie R. Lefebvre
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Correspondence to John D. Griffiths .

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  1. School of Computer Science, University of Lincoln, Lincoln, UK

    Vassilis Cutsuridis

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Griffiths, J.D., Lefebvre, J.R. (2019). Shaping Brain Rhythms: Dynamic and Control-Theoretic Perspectives on Periodic Brain Stimulation for Treatment of Neurological Disorders. In: Cutsuridis, V. (eds) Multiscale Models of Brain Disorders. Springer Series in Cognitive and Neural Systems, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-18830-6_18

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