Abstract
Basic vital functions are supposed to be shared by all living organisms and distinguish them from nonliving things. Three core vital functions recognized by most authors as the defining features of life are nutrition (feeding), interaction with the environment (social interaction), and reproduction. We herein present a psychobiological overview of the first two, the third being discussed in a separate chapter. On the other hand, instincts signify the inherent tendency of living organisms to exhibit particular complex patterns of behavior. Therefore, instinctive behaviors arise from innate biological factors and not learning or prior experience (although their expression can be modifiable by social learning) and are unconscious. They are displayed by most members of the species, thus securing the development and preservation of the individual or the species. However, the degree to which instincts determine the behavior of animals varies across species, with education/learning contributing more than instinct in shaping behavior the higher a species stands on the evolutionary ladder. We discuss how psychological schools such as psychoanalysis and ethology have historically viewed two major kinds of instincts, aggression and sexuality, and provide a psychobiological overview of the former, with the latter being discussed in a separate chapter.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Adan RA, Vanderschuren LJ, la Fleur SE (2008) Anti-obesity drugs and neural circuits of feeding. Trends Pharmacol Sci 29(4):208–217. https://doi.org/10.1016/j.tips.2008.01.008
Anderson SW, Bechara A, Damasio H, Tranel D, Damasio AR (1999) Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nat Neurosci 2(11):1032–1037. https://doi.org/10.1038/14833
de Araujo IE, Oliveira-Maia AJ, Sotnikova TD, Gainetdinov RR, Caron MG, Nicolelis MA, Simon SA (2008) Food reward in the absence of taste receptor signaling. Neuron 57(6):930–941. https://doi.org/10.1016/j.neuron.2008.01.032
Archer J (1991) The influence of testosterone on human aggression. Br J Psychol 82(Pt 1)):1–28
Bachevalier J, Machado CJ, Kazama A (2011) Behavioral outcomes of late-onset or early-onset orbital frontal cortex (areas 11/13) lesions in rhesus monkeys. Ann N Y Acad Sci 1239:71–86. https://doi.org/10.1111/j.1749-6632.2011.06211.x
Baribeau DA, Anagnostou E (2015) Oxytocin and vasopressin: linking pituitary neuropeptides and their receptors to social neurocircuits. Front Neurosci 9:335
Barratt ES, Stanford MS, Dowdy L, Liebman MJ, Kent TA (1999) Impulsive and premeditated aggression: a factor analysis of self-reported acts. Psychiatry Res 86(2):163–173. https://doi.org/10.1016/s0165-1781(99)00024-4
Batterham RL, ffytche DH, Rosenthal JM, Zelaya FO, Barker GJ, Withers DJ, Williams SC (2007) PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature 450(7166):106–109. https://doi.org/10.1038/nature06212
Benarroch EE (2010) Neural control of feeding behavior: overview and clinical correlations. Neurology 74(20):1643–1650. https://doi.org/10.1212/WNL.0b013e3181df0a3f
Berridge KC (2009) ‘Liking’ and ‘wanting’ food rewards: brain substrates and roles in eating disorders. Physiol Behav 97(5):537–550. https://doi.org/10.1016/j.physbeh.2009.02.044
Berthoud HR (2011) Metabolic and hedonic drives in the neural control of appetite: who is the boss? Curr Opin Neurobiol 21(6):888–896. https://doi.org/10.1016/j.conb.2011.09.004
Blanchard RJ, Blanchard DC, Takahashi T, Kelley MJ (1977) Attack and defensive behaviour in the albino rat. Anim Behav 25:622–634. https://doi.org/10.1016/0003-3472(77)90113-0
Boccia M, Petrusz P, Suzuki K, Marson L, Pedersen CA (2013) Immunohistochemical localization of oxytocin receptors in human brain. Neuroscience 253:155–164
Bohnke R, Bertsch K, Kruk MR, Richter S, Naumann E (2010) Exogenous cortisol enhances aggressive behavior in females, but not in males. Psychoneuroendocrinology 35(7):1034–1044. https://doi.org/10.1016/j.psyneuen.2010.01.004
Book AS, Starzyk KB, Quinsey VL (2001) The relationship between testosterone and aggression: a meta-analysis. Aggress Violent Behav 6(6):579–599. https://doi.org/10.1016/s1359-1789(00)00032-x
Bos PA, Hermans EJ, Ramsey NF, van Honk J (2012a) The neural mechanisms by which testosterone acts on interpersonal trust. NeuroImage 61(3):730–737. https://doi.org/10.1016/j.neuroimage.2012.04.002
Bos PA, Panksepp J, Bluthé R-M, van Honk J (2012b) Acute effects of steroid hormones and neuropeptides on human social–emotional behavior: a review of single administration studies. Front Neuroendocrinol 33(1):17–35
Brown GL, Ebert MH, Goyer PF, Jimerson DC, Klein WJ, Bunney WE, Goodwin FK (1982) Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry 139(6):741–746. https://doi.org/10.1176/ajp.139.6.741
de Bruin JP, van Oyen HG, Van de Poll N (1983) Behavioural changes following lesions of the orbital prefrontal cortex in male rats. Behav Brain Res 10(2–3):209–232
Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA (1993) Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262(5133):578–580. https://doi.org/10.1126/science.8211186
Budhani S, Blair RJ (2005) Response reversal and children with psychopathic tendencies: success is a function of salience of contingency change. J Child Psychol Psychiatry 46(9):972–981. https://doi.org/10.1111/j.1469-7610.2004.00398.x
Budhani S, Marsh AA, Pine DS, Blair RJ (2007) Neural correlates of response reversal: considering acquisition. NeuroImage 34(4):1754–1765. https://doi.org/10.1016/j.neuroimage.2006.08.060
Carter CS (2007) Sex differences in oxytocin and vasopressin: implications for autism spectrum disorders? Behav Brain Res 176(1):170–186
Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Muller U, Aguet M, Babinet C, Shih JC et al (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268(5218):1763–1766. https://doi.org/10.1126/science.7792602
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R (2002) Role of genotype in the cycle of violence in maltreated children. Science 297(5582):851–854. https://doi.org/10.1126/science.1072290
Chaudhri O, Small C, Bloom S (2006) Gastrointestinal hormones regulating appetite. Philos Trans R Soc Lond Ser B Biol Sci 361(1471):1187–1209. https://doi.org/10.1098/rstb.2006.1856
Chodasewicz K (2014) Evolution, reproduction and definition of life. Theor Biosci 133(1):39–45. https://doi.org/10.1007/s12064-013-0184-5
Cicchetti D, Rogosch FA, Thibodeau EL (2012) The effects of child maltreatment on early signs of antisocial behavior: genetic moderation by tryptophan hydroxylase, serotonin transporter, and monoamine oxidase A genes. Dev Psychopathol 24(3):907–928. https://doi.org/10.1017/S0954579412000442
Cleland CE, Chyba CF (2002) Defining ‘life’. Origins of life and evolution of the biosphere. J Int Soc Stud Origin Life 32(4):387–393
Coccaro EF, Kavoussi RJ, Sheline YI, Lish JD, Csernansky JG (1996) Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Arch Gen Psychiatry 53(6):531–536
Coccaro EF, Kavoussi RJ, Cooper TB, Hauger RL (1997a) Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. Am J Psychiatry 154(10):1430–1435. https://doi.org/10.1176/ajp.154.10.1430
Coccaro EF, Kavoussi RJ, Sheline YI, Berman ME, Csernansky JG (1997b) Impulsive aggression in personality disorder correlates with platelet 5-HT2A receptor binding. Neuropsychopharmacology 16(3):211–216. https://doi.org/10.1016/S0893-133X(96)00194-7
Coccaro EF, Kavoussi RJ, Hauger RL, Cooper TB, Ferris CF (1998) Cerebrospinal fluid vasopressin levels: correlates with aggression and serotonin function in personality-disordered subjects. Arch Gen Psychiatry 55(8):708–714
Coccaro EF, McCloskey MS, Fitzgerald DA, Phan KL (2007) Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggression. Biol Psychiatry 62(2):168–178. https://doi.org/10.1016/j.biopsych.2006.08.024
Coccaro EF, Sripada CS, Yanowitch RN, Phan KL (2011) Corticolimbic function in impulsive aggressive behavior. Biol Psychiatry 69(12):1153–1159. https://doi.org/10.1016/j.biopsych.2011.02.032
Costafreda SG, Brammer MJ, David AS, Fu CH (2008) Predictors of amygdala activation during the processing of emotional stimuli: a meta-analysis of 385 PET and fMRI studies. Brain Res Rev 58(1):57–70
Craig AD (2009) How do you feel—now? The anterior insula and human awareness. Nat Rev Neurosci 10(1):59–70. https://doi.org/10.1038/nrn2555
Crockford C, Deschner T, Ziegler TE, Wittig RM (2014) Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review. Front Behav Neurosci 8(68):68. https://doi.org/10.3389/fnbeh.2014.00068
Dadds MR, Perry Y, Hawes DJ, Merz S, Riddell AC, Haines DJ, Solak E, Abeygunawardane AI (2006) Attention to the eyes and fear-recognition deficits in child psychopathy. Br J Psychiatry 189(3):280–281. https://doi.org/10.1192/bjp.bp.105.018150
Damasio H, Grabowski T, Frank R, Galaburda AM, Damasio AR (1994) The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science 264(5162):1102–1105
Davidson RJ, Putnam KM, Larson CL (2000) Dysfunction in the neural circuitry of emotion regulation—a possible prelude to violence. Science 289(5479):591–594. https://doi.org/10.1126/science.289.5479.591
De Dreu CK (2012) Oxytocin modulates cooperation within and competition between groups: an integrative review and research agenda. Horm Behav 61(3):419–428
Dickstein DP, Finger EC, Brotman MA, Rich BA, Pine DS, Blair JR, Leibenluft E (2010) Impaired probabilistic reversal learning in youths with mood and anxiety disorders. Psychol Med 40(7):1089–1100. https://doi.org/10.1017/S0033291709991462
Dietrich MO, Horvath TL (2009) Feeding signals and brain circuitry. Eur J Neurosci 30(9):1688–1696. https://doi.org/10.1111/j.1460-9568.2009.06963.x
Ditzen B, Heinrichs M (2014) Psychobiology of social support: the social dimension of stress buffering. Restor Neurol Neurosci 32(1):149–162. https://doi.org/10.3233/RNN-139008
Dolan M, Fullam R (2006) Face affect recognition deficits in personality-disordered offenders: association with psychopathy. Psychol Med 36(11):1563. https://doi.org/10.1017/s0033291706008634
Duncan LE, Keller MC (2011) A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. Am J Psychiatr 168(10):1041–1049
Eisenberger NI, Master SL, Inagaki TK, Taylor SE, Shirinyan D, Lieberman MD, Naliboff BD (2011) Attachment figures activate a safety signal-related neural region and reduce pain experience. Proc Natl Acad Sci 108(28):11721–11726
Falkner AL, Grosenick L, Davidson TJ, Deisseroth K, Lin D (2016) Hypothalamic control of male aggression-seeking behavior. Nat Neurosci 19(4):596–604. https://doi.org/10.1038/nn.4264
Fang PH, Yu M, Ma YP, Li J, Sui YM, Shi MY (2011) Central nervous system regulation of food intake and energy expenditure: role of galanin-mediated feeding behavior. Neurosci Bull 27(6):407–412. https://doi.org/10.1007/s12264-011-1841-7
Farooqi IS, O'Rahilly S (2008) Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity. Nat Clin Pract Endocrinol Metab 4(10):569–577. https://doi.org/10.1038/ncpendmet0966
Ferris CF, Potegal M (1988) Vasopressin receptor blockade in the anterior hypothalamus suppresses aggression in hamsters. Physiol Behav 44(2):235–239
Frankle WG, Lombardo I, New AS, Goodman M, Talbot PS, Huang Y, Hwang DR, Slifstein M, Curry S, Abi-Dargham A, Laruelle M, Siever LJ (2005) Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652. Am J Psychiatry 162(5):915–923. https://doi.org/10.1176/appi.ajp.162.5.915
Freud S (1920) Beyond the pleasure principle. Interaationaler Psycho Analytischer Verlag, Vienna
Freud S (1923) The ego and the Id. Interaationaler Psycho Analytischer Verlag, Vienna
Fuller JL (1954) Nature and nurture: a modern synthesis. Doubleday, New York, NY
Galbally M, Lewis AJ, Ijzendoorn M, Permezel M (2011) The role of oxytocin in mother-infant relations: a systematic review of human studies. Harv Rev Psychiatry 19(1):1–14. https://doi.org/10.3109/10673229.2011.549771
Gao Q, Horvath TL (2007) Neurobiology of feeding and energy expenditure. Annu Rev Neurosci 30:367–398. https://doi.org/10.1146/annurev.neuro.30.051606.094324
Gelles RJ (1994) Aggression – its causes, consequences, and control – Berkowitz, L. Contemp Sociol 23(4):575–576. https://doi.org/10.2307/2076412
Gettler LT (2014) Applying socioendocrinology to evolutionary models: fatherhood and physiology. Evol Anthropol 23(4):146–160. https://doi.org/10.1002/evan.21412
Ghashghaei HT, Barbas H (2002) Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey. Neuroscience 115(4):1261–1279
Goetz SM, Tang L, Thomason ME, Diamond MP, Hariri AR, Carre JM (2014) Testosterone rapidly increases neural reactivity to threat in healthy men: a novel two-step pharmacological challenge paradigm. Biol Psychiatry 76(4):324–331. https://doi.org/10.1016/j.biopsych.2014.01.016
van Goozen SH, Fairchild G, Snoek H, Harold GT (2007) The evidence for a neurobiological model of childhood antisocial behavior. Psychol Bull 133(1):149–182. https://doi.org/10.1037/0033-2909.133.1.149
Gorrindo T, Blair RJ, Budhani S, Dickstein DP, Pine DS, Leibenluft E (2005) Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder. Am J Psychiatry 162(10):1975–1977. https://doi.org/10.1176/appi.ajp.162.10.1975
Gregg TR, Siegel A (2001) Brain structures and neurotansmitters regulating aggression in cats: implications for human aggression. Prog Neuro-Psychopharmacol Biol Psychiatry 25(1):91–140. https://doi.org/10.1016/s0278-5846(00)00150-0
Guyon A, Conductier G, Rovere C, Enfissi A, Nahon JL (2009) Melanin-concentrating hormone producing neurons: activities and modulations. Peptides 30(11):2031–2039. https://doi.org/10.1016/j.peptides.2009.05.028
Haller J, van de Schraaf J, Kruk MR (2001) Deviant forms of aggression in glucocorticoid hyporeactive rats: a model for ‘pathological’ aggression? J Neuroendocrinol 13(1):102–107
Hamson DK, Jones BA, Watson NV (2004) Distribution of androgen receptor immunoreactivity in the brainstem of male rats. Neuroscience 127(4):797–803. https://doi.org/10.1016/j.neuroscience.2004.06.006
Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, Weinberger DR (2002) Serotonin transporter genetic variation and the response of the human amygdala. Science 297(5580):400–403. https://doi.org/10.1126/science.1071829
Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF, Weinberger DR (2005) A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 62(2):146–152. https://doi.org/10.1001/archpsyc.62.2.146
Harris GC, Aston-Jones G (2006) Arousal and reward: a dichotomy in orexin function. Trends Neurosci 29(10):571–577. https://doi.org/10.1016/j.tins.2006.08.002
von Hausswolff-Juhlin Y, Brooks SJ, Larsson M (2015) The neurobiology of eating disorders—a clinical perspective. Acta Psychiatr Scand 131(4):244–255. https://doi.org/10.1111/acps.12335
Hazell PL, Stuart JE (2003) A randomized controlled trial of clonidine added to psychostimulant medication for hyperactive and aggressive children. J Am Acad Child Adolesc Psychiatry 42(8):886–894. https://doi.org/10.1097/01.CHI.0000046908.27264.00
Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66(6):2621–2624
Heinrichs M, Domes G (2008) Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans. Prog Brain Res 170:337–350
Heinrichs M, von Dawans B, Domes G (2009) Oxytocin, vasopressin, and human social behavior. Front Neuroendocrinol 30(4):548–557. https://doi.org/10.1016/j.yfrne.2009.05.005
Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H, Lee CE, Cone RD, Elmquist JK (2002) Activation of central melanocortin pathways by fenfluramine. Science 297(5581):609–611. https://doi.org/10.1126/science.1072327
Hermans EJ, Ramsey NF, van Honk J (2008) Exogenous testosterone enhances responsiveness to social threat in the neural circuitry of social aggression in humans. Biol Psychiatry 63(3):263–270. https://doi.org/10.1016/j.biopsych.2007.05.013
Hewitt JK (2012) Editorial policy on candidate gene association and candidate gene-by-environment interaction studies of complex traits. Behav Genet 42(1):1–2
Hillebrand JJ, Kas MJ, Adan RA (2006) To eat or not to eat; regulation by the melanocortin system. Physiol Behav 89(1):97–102. https://doi.org/10.1016/j.physbeh.2006.01.034
Holmes A, Murphy DL, Crawley JN (2002) Reduced aggression in mice lacking the serotonin transporter. Psychopharmacology 161(2):160–167. https://doi.org/10.1007/s00213-002-1024-3
Hostinar CE, Sullivan RM, Gunnar MR (2014) Psychobiological mechanisms underlying the social buffering of the hypothalamic-pituitary-adrenocortical axis: a review of animal models and human studies across development. Psychol Bull 140(1):256–282. https://doi.org/10.1037/a0032671
Huber D, Veinante P, Stoop R (2005) Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 308(5719):245–248. https://doi.org/10.1126/science.1105636
Insel TR (2010) The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. Neuron 65(6):768–779
Ito M, Okazaki M, Takahashi S, Muramatsu R, Kato M, Onuma T (2007) Subacute postictal aggression in patients with epilepsy. Epilepsy Behav 10(4):611–614. https://doi.org/10.1016/j.yebeh.2007.02.016
Jokinen J, Chatzittofis A, Hellstrom C, Nordstrom P, Uvnas-Moberg K, Asberg M (2012) Low CSF oxytocin reflects high intent in suicide attempters. Psychoneuroendocrinology 37(4):482–490. https://doi.org/10.1016/j.psyneuen.2011.07.016
Kageyama H, Takenoya F, Shiba K, Shioda S (2010) Neuronal circuits involving ghrelin in the hypothalamus-mediated regulation of feeding. Neuropeptides 44(2):133–138. https://doi.org/10.1016/j.npep.2009.11.010
Kaitz M, Shalev I, Sapir N, Devor N, Samet Y, Mankuta D, Ebstein RP (2010) Mothers’ dopamine receptor polymorphism modulates the relation between infant fussiness and sensitive parenting. Dev Psychobiol 52(2):149–157
Kampe J, Tschop MH, Hollis JH, Oldfield BJ (2009) An anatomic basis for the communication of hypothalamic, cortical and mesolimbic circuitry in the regulation of energy balance. Eur J Neurosci 30(3):415–430. https://doi.org/10.1111/j.1460-9568.2009.06818.x
Kelley AE, Baldo BA, Pratt WE, Will MJ (2005) Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol Behav 86(5):773–795. https://doi.org/10.1016/j.physbeh.2005.08.066
Keverne EB, Curley JP (2004) Vasopressin, oxytocin and social behaviour. Curr Opin Neurobiol 14(6):777–783
Kiehl KA, Smith AM, Hare RD, Mendrek A, Forster BB, Brink J, Liddle PF (2001) Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biol Psychiatry 50(9):677–684
Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW, Moffitt TE (2006) MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis. Mol Psychiatry 11(10):903–913. https://doi.org/10.1038/sj.mp.4001851
King BM (2006) The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. Physiol Behav 87(2):221–244. https://doi.org/10.1016/j.physbeh.2005.10.007
Kis A, Kemerle K, Hernadi A, Topal J (2013) Oxytocin and social pretreatment have similar effects on processing of negative emotional faces in healthy adult males. Front Psychol 4:532. https://doi.org/10.3389/fpsyg.2013.00532
Knutson B, Wolkowitz OM, Cole SW, Chan T, Moore EA, Johnson RC, Terpstra J, Turner RA, Reus VI (1998) Selective alteration of personality and social behavior by serotonergic intervention. Am J Psychiatry 155(3):373–379. https://doi.org/10.1176/ajp.155.3.373
Kokras N, Sotiropoulos I, Pitychoutis PM, Almeida OFX, Papadopoulou-Daifoti Z (2011) Citalopram-mediated anxiolysis and differing neurobiological responses in both sexes of a genetic model of depression. Neuroscience 194:62–71. https://doi.org/10.1016/j.neuroscience.2011.07.077
Konner AC, Klockener T, Bruning JC (2009) Control of energy homeostasis by insulin and leptin: targeting the arcuate nucleus and beyond. Physiol Behav 97(5):632–638. https://doi.org/10.1016/j.physbeh.2009.03.027
Koshland DE Jr (2002) Special essay. The seven pillars of life. Science 295(5563):2215–2216. https://doi.org/10.1126/science.1068489
Krakowski MI, Czobor P, Citrome L, Bark N, Cooper TB (2006) Atypical antipsychotic agents in the treatment of violent patients with schizophrenia and schizoaffective disorder. Arch Gen Psychiatry 63(6):622–629. https://doi.org/10.1001/archpsyc.63.6.622
Lass-Hennemann J, Kuehl LK, Schulz A, Oitzl MS, Schachinger H (2011) Stress strengthens memory of first impressions of others’ positive personality traits. PLoS One 6(1):e16389. https://doi.org/10.1371/journal.pone.0016389
Lee R, Ferris C, Van de Kar LD, Coccaro EF (2009) Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder. Psychoneuroendocrinology 34(10):1567–1573. https://doi.org/10.1016/j.psyneuen.2009.06.002
Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274(5292):1527–1531
Lieving LM, Cherek DR, Lane SD, Tcheremissine OV, Nouvion SO (2008) Effects of acute tiagabine administration on aggressive responses of adult male parolees. J Psychopharmacol 22(2):144–152. https://doi.org/10.1177/0269881107078489
Lin D, Boyle MP, Dollar P, Lee H, Lein ES, Perona P, Anderson DJ (2011) Functional identification of an aggression locus in the mouse hypothalamus. Nature 470(7333):221–226. https://doi.org/10.1038/nature09736
Lopez-Duran NL, Olson SL, Hajal NJ, Felt BT, Vazquez DM (2009) Hypothalamic pituitary adrenal axis functioning in reactive and proactive aggression in children. J Abnorm Child Psychol 37(2):169–182. https://doi.org/10.1007/s10802-008-9263-3
Lorenz KZ (1950) The comparative method in studying innate behaviour patterns. Symp Soc Exp Biol 4:221–268
Lorenz K (1952) King Solomon’s ring. Crowell, New York, NY
Lubin DA, Elliott JC, Black MC, Johns JM (2003) An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior. Behav Neurosci 117(2):195–201
Lutter M, Nestler EJ (2009) Homeostatic and hedonic signals interact in the regulation of food intake. J Nutr 139(3):629–632. https://doi.org/10.3945/jn.108.097618
Machado CJ, Bachevalier J (2008) Behavioral and hormonal reactivity to threat: effects of selective amygdala, hippocampal or orbital frontal lesions in monkeys. Psychoneuroendocrinology 33(7):926–941. https://doi.org/10.1016/j.psyneuen.2008.04.012
Marino MD, Bourdelat-Parks BN, Cameron Liles L, Weinshenker D (2005) Genetic reduction of noradrenergic function alters social memory and reduces aggression in mice. Behav Brain Res 161(2):197–203. https://doi.org/10.1016/j.bbr.2005.02.005
Marsh AA, Blair RJ (2008) Deficits in facial affect recognition among antisocial populations: a meta-analysis. Neurosci Biobehav Rev 32(3):454–465. https://doi.org/10.1016/j.neubiorev.2007.08.003
Marsh DM, Dougherty DM, Moeller FG, Swann AC, Spiga R (2002) Laboratory-measured aggressive behavior of women: acute tryptophan depletion and augmentation. Neuropsychopharmacology 26(5):660–671. https://doi.org/10.1016/S0893-133X(01)00369-4
Marsh AA, Finger EC, Mitchell DG, Reid ME, Sims C, Kosson DS, Towbin KE, Leibenluft E, Pine DS, Blair RJ (2008) Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders. Am J Psychiatry 165(6):712–720. https://doi.org/10.1176/appi.ajp.2007.07071145
Marsh AA, Finger EC, Fowler KA, Jurkowitz ITN, Schechter JC, Yu HH, Pine DS, Blair RJR (2011) Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits. Psychiatry Res 194(3):279–286. https://doi.org/10.1016/j.pscychresns.2011.07.008
McBurnett K, Lahey BB, Rathouz PJ, Loeber R (2000) Low salivary cortisol and persistent aggression in boys referred for disruptive behavior. Arch Gen Psychiatry 57(1):38–43
Meister B (2007) Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight. Physiol Behav 92(1–2):263–271. https://doi.org/10.1016/j.physbeh.2007.05.021
Meyer-Lindenberg A, Buckholtz JW, Kolachana B, RH A, Pezawas L, Blasi G, Wabnitz A, Honea R, Verchinski B, Callicott JH, Egan M, Mattay V, Weinberger DR (2006) Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc Natl Acad Sci U S A 103(16):6269–6274. https://doi.org/10.1073/pnas.0511311103
Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M (2011) Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci 12(9):524–538
Miczek KA, Maxson SC, Fish EW, Faccidomo S (2001) Aggressive behavioral phenotypes in mice. Behav Brain Res 125(1–2):167–181
Miczek KA, Fish EW, De Bold JF, De Almeida RM (2002) Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems. Psychopharmacology 163(3–4):434–458. https://doi.org/10.1007/s00213-002-1139-6
Miles DR, Carey G (1997) Genetic and environmental architecture of human aggression. J Pers Soc Psychol 72(1):207–217
Mileva-Seitz V, Fleming AS, Meaney MJ, Mastroianni A, Sinnwell JP, Steiner M, Atkinson L, Levitan RD, Matthews SG, Kennedy JL, Sokolowski MB (2012) Dopamine receptors D1 and D2 are related to observed maternal behavior. Genes Brain Behav 11(6):684–694. https://doi.org/10.1111/j.1601-183X.2012.00804.x
Murray S, Tulloch A, Gold MS, Avena NM (2014) Hormonal and neural mechanisms of food reward, eating behaviour and obesity. Nat Rev Endocrinol 10(9):540–552. https://doi.org/10.1038/nrendo.2014.91
Nelson RJ, Trainor BC (2007) Neural mechanisms of aggression. Nat Rev Neurosci 8(7):536–546. https://doi.org/10.1038/nrn2174
Neumann ID, Landgraf R (2012) Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. Trends Neurosci 35(11):649–659
Olazabal DE, Pereira M, Agrati D, Ferreira A, Fleming AS, Gonzalez-Mariscal G, Levy F, Lucion AB, Morrell JI, Numan M, Uriarte N (2013) Flexibility and adaptation of the neural substrate that supports maternal behavior in mammals. Neurosci Biobehav Rev 37(8):1875–1892. https://doi.org/10.1016/j.neubiorev.2013.04.004
Ordonana JR, Bartels M, Boomsma DI, Cella D, Mosing M, Oliveira JR, Patrick DL, Veenhoven R, Wagner GG, Sprangers MA, Consortium G (2013) Biological pathways and genetic mechanisms involved in social functioning. Qual Life Res 22(6):1189–1200. https://doi.org/10.1007/s11136-012-0277-5
Panksepp J (1998) Affective neuroscience: the foundations of human and animal emotions. Oxford University Press, New York, NY
Panksepp J (2016) The cross-mammalian neurophenomenology of primal emotional affects: from animal feelings to human therapeutics. J Comp Neurol 524(8):1624–1635. https://doi.org/10.1002/cne.23969
Passamonti L, Fera F, Magariello A, Cerasa A, Gioia MC, Muglia M, Nicoletti G, Gallo O, Provinciali L, Quattrone A (2006) Monoamine oxidase-A genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity. Biol Psychiatry 59(4):334–340. https://doi.org/10.1016/j.biopsych.2005.07.027
Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR (2005) 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8(6):828–834. https://doi.org/10.1038/nn1463
Pope HG Jr, Kouri EM, Hudson JI (2000) Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: a randomized controlled trial. Arch Gen Psychiatry 57(2):133–140. discussion 155–156
Popma A, Vermeiren R, Geluk CA, Rinne T, van den Brink W, Knol DL, Jansen LM, van Engeland H, Doreleijers TA (2007) Cortisol moderates the relationship between testosterone and aggression in delinquent male adolescents. Biol Psychiatry 61(3):405–411. https://doi.org/10.1016/j.biopsych.2006.06.006
Poulin F, Boivin M (2000) Reactive and proactive aggression: evidence of a two-factor model. Psychol Assess 12(2):115–122
Ragnauth AK, Devidze N, Moy V, Finley K, Goodwillie A, Kow LM, Muglia LJ, Pfaff DW (2005) Female oxytocin gene-knockout mice, in a semi-natural environment, display exaggerated aggressive behavior. Genes Brain Behav 4(4):229–239. https://doi.org/10.1111/j.1601-183X.2005.00118.x
Reif A, Rosler M, Freitag CM, Schneider M, Eujen A, Kissling C, Wenzler D, Jacob CP, Retz-Junginger P, Thome J, Lesch KP, Retz W (2007) Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment. Neuropsychopharmacology 32(11):2375–2383. https://doi.org/10.1038/sj.npp.1301359
Rilling JK, Young LJ (2014) The biology of mammalian parenting and its effect on offspring social development. Science 345(6198):771–776
Rodriguiz RM, Chu R, Caron MG, Wetsel WC (2004) Aberrant responses in social interaction of dopamine transporter knockout mice. Behav Brain Res 148(1–2):185–198
Rogge G, Jones D, Hubert GW, Lin Y, Kuhar MJ (2008) CART peptides: regulators of body weight, reward and other functions. Nat Rev Neurosci 9(10):747–758. https://doi.org/10.1038/nrn2493
Sabol SZ, Hu S, Hamer D (1998) A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 103(3):273–279
Salvador A, Costa R (2009) Coping with competition: neuroendocrine responses and cognitive variables. Neurosci Biobehav Rev 33(2):160–170. https://doi.org/10.1016/j.neubiorev.2008.09.005
Saper CB, Chou TC, Elmquist JK (2002) The need to feed: homeostatic and hedonic control of eating. Neuron 36(2):199–211
Saudou F, Amara DA, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot MC, Hen R (1994) Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science 265(5180):1875–1878
Seo D, Patrick CJ, Kennealy PJ (2008) Role of serotonin and dopamine system interactions in the neurobiology of impulsive aggression and its comorbidity with other clinical disorders. Aggress Violent Behav 13(5):383–395. https://doi.org/10.1016/j.avb.2008.06.003
Shin AC, Zheng H, Berthoud HR (2009) An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. Physiol Behav 97(5):572–580. https://doi.org/10.1016/j.physbeh.2009.02.010
Siegel A, Roeling TA, Gregg TR, Kruk MR (1999) Neuropharmacology of brain-stimulation-evoked aggression. Neurosci Biobehav Rev 23(3):359–389
Siever LJ (2008) Neurobiology of aggression and violence. Am J Psychiatry 165(4):429–442. https://doi.org/10.1176/appi.ajp.2008.07111774
Siever LJ, Buchsbaum MS, New AS, Spiegel-Cohen J, Wei T, Hazlett EA, Sevin E, Nunn M, Mitropoulou V (1999) d,l-fenfluramine response in impulsive personality disorder assessed with [18F]fluorodeoxyglucose positron emission tomography. Neuropsychopharmacology 20(5):413–423. https://doi.org/10.1016/S0893-133X(98)00111-0
Silver JM, Yudofsky SC, Slater JA, Gold RK, Stryer BL, Williams DT, Wolland H, Endicott J (1999) Propranolol treatment of chronically hospitalized aggressive patients. J Neuropsychiatry Clin Neurosci 11(3):328–335. https://doi.org/10.1176/jnp.11.3.328
Simon GE, Von Korff M, Saunders K, Miglioretti DL, Crane PK, van Belle G, Kessler RC (2006) Association between obesity and psychiatric disorders in the US adult population. Arch Gen Psychiatry 63(7):824–830. https://doi.org/10.1001/archpsyc.63.7.824
Skuse DH, Gallagher L (2009) Dopaminergic-neuropeptide interactions in the social brain. Trends Cogn Sci 13(1):27–35. https://doi.org/10.1016/j.tics.2008.09.007
Sokolowski K, Corbin JG (2012) Wired for behaviors: from development to function of innate limbic system circuitry. Front Mol Neurosci 5:55. https://doi.org/10.3389/fnmol.2012.00055
Soloff PH, Meltzer CC, Greer PJ, Constantine D, Kelly TM (2000) A fenfluramine-activated FDG-PET study of borderline personality disorder. Biol Psychiatry 47(6):540–547
Soloff PH, Price JC, Meltzer CC, Fabio A, Frank GK, Kaye WH (2007) 5HT2A receptor binding is increased in borderline personality disorder. Biol Psychiatry 62(6):580–587. https://doi.org/10.1016/j.biopsych.2006.10.022
Somerville LH, Fani N, McClure-Tone EB (2011) Behavioral and neural representation of emotional facial expressions across the lifespan. Dev Neuropsychol 36(4):408–428. https://doi.org/10.1080/87565641.2010.549865
Stein DJ (2015) Social anxiety disorder and the psychobiology of self-consciousness. Front Hum Neurosci 9:489. https://doi.org/10.3389/fnhum.2015.00489
Stein DJ, Vythilingum B (2009) Love and attachment: the psychobiology of social bonding. CNS Spectr 14(5):239–242
Storey AE, Walsh CJ, Quinton RL, Wynne-Edwards KE (2000) Hormonal correlates of paternal responsiveness in new and expectant fathers. Evol Hum Behav 21(2):79–95
Taylor SE (2006) Tend and befriend biobehavioral bases of affiliation under stress. Curr Dir Psychol Sci 15(6):273–277
Taylor SE, Klein LC, Lewis BP, Gruenewald TL, Gurung RA, Updegraff JA (2000) Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight. Psychol Rev 107(3):411
Taylor SE, Saphire-Bernstein S, Seeman TE (2010) Are plasma oxytocin in women and plasma vasopressin in men biomarkers of distressed pair-bond relationships? Psychol Sci 21(1):3–7
Terburg D, Morgan B, van Honk J (2009) The testosterone-cortisol ratio: a hormonal marker for proneness to social aggression. Int J Law Psychiatry 32(4):216–223. https://doi.org/10.1016/j.ijlp.2009.04.008
Thompson RR, George K, Walton JC, Orr SP, Benson J (2006) Sex-specific influences of vasopressin on human social communication. Proc Natl Acad Sci U S A 103(20):7889–7894. https://doi.org/10.1073/pnas.0600406103
Tinbergen N (1951) The study of instinct. Clarendon Press, Oxford
Tsujino N, Sakurai T (2009) Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system. Pharmacol Rev 61(2):162–176. https://doi.org/10.1124/pr.109.001321
Van Anders SM, Goldey KL, Kuo PX (2011) The steroid/peptide theory of social bonds: integrating testosterone and peptide responses for classifying social behavioral contexts. Psychoneuroendocrinology 36(9):1265–1275
Vassos E, Collier DA, Fazel S (2014) Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression. Mol Psychiatry 19(4):471–477. https://doi.org/10.1038/mp.2013.31
Verona E, Joiner TE, Johnson F, Bender TW (2006) Gender specific gene-environment interactions on laboratory-assessed aggression. Biol Psychol 71(1):33–41. https://doi.org/10.1016/j.biopsycho.2005.02.001
Viding E, Blair RJ, Moffitt TE, Plomin R (2005) Evidence for substantial genetic risk for psychopathy in 7-year-olds. J Child Psychol Psychiatry 46(6):592–597. https://doi.org/10.1111/j.1469-7610.2004.00393.x
Vukhac KL, Sankoorikal EB, Wang Y (2001) Dopamine D2L receptor- and age-related reduction in offensive aggression. Neuroreport 12(5):1035–1038
Wersinger SR, Caldwell HK, Christiansen M, Young WS 3rd (2007) Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice. Genes Brain Behav 6(7):653–660. https://doi.org/10.1111/j.1601-183X.2006.00294.x
WHO (2010) Injuries and violence: the facts. World Health Organization, Geneva
Williams KW, Elmquist JK (2012) From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior. Nat Neurosci 15(10):1350–1355. https://doi.org/10.1038/nn.3217
Williams G, Bing C, Cai XJ, Harrold JA, King PJ, Liu XH (2001) The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol Behav 74(4–5):683–701
Wood RM, Rilling JK, Sanfey AG, Bhagwagar Z, Rogers RD (2006) Effects of tryptophan depletion on the performance of an iterated Prisoner’s Dilemma game in healthy adults. Neuropsychopharmacology 31(5):1075–1084. https://doi.org/10.1038/sj.npp.1300932
Wundt W (1874) Principles of physiological psychology. Engelman, Leipzig
Wynne-Edwards KE (2001) Hormonal changes in mammalian fathers. Horm Behav 40(2):139–145. https://doi.org/10.1006/hbeh.2001.1699
Zink CF, Meyer-Lindenberg A (2012) Human neuroimaging of oxytocin and vasopressin in social cognition. Horm Behav 61(3):400–409. https://doi.org/10.1016/j.yhbeh.2012.01.016
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Ferentinos, P., Kokras, N., Konstantakopoulos, G. (2019). Basic Vital Functions and Instincts. In: Fountoulakis, K., Nimatoudis, I. (eds) Psychobiology of Behaviour. Springer, Cham. https://doi.org/10.1007/978-3-030-18323-3_3
Download citation
DOI: https://doi.org/10.1007/978-3-030-18323-3_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-18322-6
Online ISBN: 978-3-030-18323-3
eBook Packages: MedicineMedicine (R0)