Rolling Circle Replication and Transcription Processes in Geminiviruses

  • Nivedita Sharma
  • Rajrani Ruhel


Geminivirus causes a tremendous loss in plant yield and the infection occurs in terminally differentiated plant cells wherein in order to complete its life cycle, the host gene expression is induced and also the host cell cycle machinery is modulated (Nagar et al. The Plant Cell 7:705–719, 1995; Hanley-Bowdoin et al. Nat Rev Microbiol 11:777–788, 2013). The small-sized (~2.7 kb) genome of geminivirus utilizes a bidirectional mode of transcription and has overlapping genes in different frames for its efficient usage. Functional studies on various mutants of the entire open reading frames of Tomato golden mosaic virus concluded that the Rep is the only viral protein absolutely necessary for its replication. In addition, it is also involved in the process of transcription and regulates the expression of certain viral genes. The main purpose of this chapter is to provide brief insights into the replication and transcription pathway of geminivirus.


Geminivirus Replication Transcription ORF 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nivedita Sharma
    • 1
  • Rajrani Ruhel
    • 1
  1. 1.School of Life SciencesJawaharlal Nehru UniversityNew DelhiIndia

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