Abstract
Muscle relaxing drugs do not seem to increase the risk for major malformations and the increased risk of minor anomalies is probably not causal but due to uneven reporting. Among drugs used for gout, some uncertainty exists for allopurinol with a possible association with a pattern of malformations but further data are needed to evaluate this. If true, the absolute risk appears to be low. Data on bisphosphonates during pregnancy are few but indicate no or low teratogenic risk. Further data are needed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Djokanovic N, Klieger-Grossmann C, Koren G. Does treatment with bisphosphonates endanger the human pregnancy? J Obstet Gynaecol Can. 2008;30:1146–8.
Green SB, Pappas AL. Effects of maternal biphosphonate use on fetal and neonatal outcomes. Am J Health Syst Pharm. 2014;71:2029–36.
Heinonen OP, Slone D, Shapiro S. Birth defects and drugs in pregnancy. Littleton, MA: Publishing Sciences Group; 1977.
Hoeltzenbein M, Stieler K, Panse M, Wacker E, Schaefer C. Allopurinol use during pregnancy—outcome of 31 prospectively ascertained cases and a phenotype possibly indicative for teratogenicity. PLoS One. 2013;8:e66637. https://doi.org/10.1371/journal.pone/0066637.
Kozenko M, Grynspan D, Oluyomi T, Sitar D, Elliott AM, Chodirker BN. Potential teratogenic effects of allopurinol: a case report. Am J Med Genet A. 2011;155A:2247–52.
McKenna B, Mansfield JC. Safety of biphosphonates in women of child bearing age. Aliment Pharmacol Ther. 2009;29:1212–5.
Sokal A, Elefant-Amoura E, Leturcq T, Beghin D, Mariette X, Seror R. Biphosphonate during pregnancy: a prospective study. Ann Rheum Dis. 2016;75:93.
Stathopoulos PJ, Liakou GC, Katsalira A, Trovas G, Lyritis G, Papaioannou AN, Tournis S. The use of bisphosphonates in women prior to or during pregnancy and lactation. Hormones. 2011;10:280–91.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Källén, B. (2019). Maternal Use of Other Drugs than NSAIDs for Musculoskeletal Diseases and Infant Congenital Malformations. In: Maternal Drug Use and Infant Congenital Malformations. Springer, Cham. https://doi.org/10.1007/978-3-030-17898-7_20
Download citation
DOI: https://doi.org/10.1007/978-3-030-17898-7_20
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-17897-0
Online ISBN: 978-3-030-17898-7
eBook Packages: MedicineMedicine (R0)