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Uveal Melanoma: Prognostic Factors

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Clinical Ophthalmic Oncology

Abstract

In the context of the pathology of uveal melanomas, prognostication may be based upon tissue characteristics. The addition of cytogenetic and molecular data extracted from tumor cells may add layers of precision to prognostication. The evolution of parameters associated with prognosis suggests that combinations of tissue-based data, molecular data, and cytogenetic profiling may combine into sophisticated algorithms for prognostication. The development of new molecular markers of prognosis and algorithms suggests that the material presented in this chapter will be subject to ongoing refinement well into the future.

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References

  1. Collaborative ocular melanoma study (COMOS) randomized trial of pre-enucleation radiation for large choroidal melanoma – II – initial mortality findings – COMS report no. 10. Am J Ophthalmol. 1998;126:622.

    Google Scholar 

  2. Damato B, Eleuteri A, Taktak AF, et al. Estimating prognosis for survival after treatment of choroidal melanoma. Prog Retin Eye Res. 2011;30:285–95.

    Article  Google Scholar 

  3. Shammas HF, Blodi FC. Prognostic factors in choroidal and ciliary body melanomas. Arch Ophthalmol. 1977;95:63–9.

    Article  CAS  Google Scholar 

  4. Kaiserman I, Anteby I, Chowers I, et al. Post-brachytherapy initial tumour regression rate correlates with metastatic spread in posterior uveal melanoma. Br J Ophthalmol. 2004;88:892–5.

    Article  CAS  Google Scholar 

  5. Amin MB, Greene FL, Byrd DR, et al. AJCC cancer staging manual. 8th ed. Springer Nature Publishing, New York NY; 2017.

    Google Scholar 

  6. Augsburger JJ, Gamel JW. Clinical prognostic factors in patients with posterior uveal malignant melanoma. Cancer. 1990;66:1596–600.

    Article  CAS  Google Scholar 

  7. Zloto O, Pe’er J, Frenkel S. Gender differences in clinical presentation and prognosis of uveal melanoma. Invest Ophthalmol Vis Sci. 2013;54:652–6.

    Article  Google Scholar 

  8. Char DH, Kroll S, Phillips TL. Uveal melanoma: growth rate and progression. Arch Ophthalmol. 1997;115:1014–8.

    Article  CAS  Google Scholar 

  9. Kaiserman I, Rosner M, Pe’er J. Forecasting the prognosis of choroidal melanoma with an artificial neural network. Ophthalmology. 2005;112:1608–11.

    PubMed  Google Scholar 

  10. Eleuteri A, Damato B, Coupland SE, et al. Enhancing survival prognostication in patients with choroidal melanoma by integrating pathologic, clinical and genetic predictors of metastasis. Int J Biomed Eng Technol. 2012;8:18–35.

    Article  Google Scholar 

  11. Jakobiec FA, Silbert G. Are most iris ‘melanomas’ really nevi? A clinicopathologic study of 189 lesions. Arch Ophthalmol. 1981;99:2117–32.

    Article  CAS  Google Scholar 

  12. McLean IW, Foster WD, Zimmerman LE, et al. Modifications of Callender’s classification of uveal melanoma at the Armed Forces Institute of Pathology. Am J Ophthalmol. 1983;96:502–9.

    Article  CAS  Google Scholar 

  13. Pe’er J, Gnessin H, Shargal Y, et al. PC-10 immunostaining of proliferating cell nuclear antigen (PCNA) in posterior uveal melanoma. Ophthalmology. 1994;101:56–62.

    Article  Google Scholar 

  14. de la Cruz PO Jr, Specht CS, McLean IW. Lymphocytic infiltration in uveal malignant melanoma. Cancer. 1990;65:112–5.

    Article  Google Scholar 

  15. Lin AY, Maniotis AJ, Valyi-Nagy K, et al. Distinguishing fibrovascular septa from vasculogenic mimicry patterns. Arch Pathol Lab Med. 2005;129:884–92.

    PubMed  Google Scholar 

  16. Maniotis AJ, Folberg R, Hess A, et al. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol. 1999;155:739–52.

    Article  CAS  Google Scholar 

  17. Dogrusoz M, Bagger M, van Duinen SG, et al. The prognostic value of AJCC staging in uveal melanoma is enhanced by adding chromosome 3 and 8q status. Invest Ophthalmol Vis Sci. 2017;58:833–42.

    Article  Google Scholar 

  18. Onken MD, Worley L, Tuscan MD, et al. An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma. J Mol Diagn. 2010;12:461–8.

    Article  CAS  Google Scholar 

  19. Dogrusoz M, Jager MJ, Damato B. Uveal melanoma treatment and prognostication. Asia Pac J Ophthalmol (Phila). 2017;6(2):186–96.

    Google Scholar 

  20. Klufas MA, Itty S, McCannel CA, et al. Variable results for uveal melanoma-specific gene expression profile prognostic test in choroidal metastasis. JAMA Ophthalmol. 2015;133(9):1073–6.

    Article  Google Scholar 

  21. Glasgow BJ, McCannel TA. Correlation of immunocytochemistry of BRCA1-associated Protein-1 (BAP1) with other prognostic markers in uveal melanoma. Am J Ophthalmol. 2018;189:122–6.

    Article  CAS  Google Scholar 

  22. Field MG, Decatur CL, Kurtenbach S, et al. PRAME as an independent biomarker for metastasis in uveal melanoma. Clin Cancer Res. 2016;22:1234–42.

    Article  CAS  Google Scholar 

  23. Robertson AG, Shih J, Yau C, et al. Integrative analysis identifies four molecular and clinical subsets in uveal melanoma. Cancer Cell. 2017;32(2):204–20.

    Article  CAS  Google Scholar 

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Correspondence to Robert Folberg .

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Folberg, R., Pe’er, J. (2019). Uveal Melanoma: Prognostic Factors. In: Damato, B., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-17879-6_18

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  • DOI: https://doi.org/10.1007/978-3-030-17879-6_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-17878-9

  • Online ISBN: 978-3-030-17879-6

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