Abstract
In this paper, we train a state-of-the-art deep neural network segmentation model to do fast brain volumetric segmentation from T1 MRI scans. We use image data from the ADNI and OASIS image collections and corresponding FreeSurfer automated segmentations to train our segmentation model. The model is able to do whole brain segmentation across 13 anatomical classes in seconds; in contrast, FreeSurfer takes several hours per volume. We show that this trained model can be used as a prior for other segmentation tasks, and that pre-training the model in this manner leads to better brain structure segmentation performance on a small dataset of expert-given manual segmentations.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
McEvoy, L.K., Brewer, J.B.: Quantitative structural MRI for early detection of Alzheimer’s disease. Expert Rev. Neurother. 10(11), 1675–1688 (2010)
Lama, R.K., Gwak, J., Park, J.S., Lee, S.W.: Diagnosis of Alzheimer’s disease based on structural MRI images using a regularized extreme learning machine and PCA features. J. Healthc. Eng. 2017, 11 (2017)
Kamnitsas, K., Chen, L., Ledig, C., Rueckert, D., Glocker, B.: Multi-scale 3D convolutional neural networks for lesion segmentation in brain MRI. Ischemic Stroke Lesion Segmentation 13, 46 (2015)
Maier, O., Menze, B.H., von der Gablentz, J., Häni, L., Heinrich, M.P., Liebrand, M., Winzeck, S., Basit, A., Bentley, P., Chen, L., et al.: ISLES 2015-a public evaluation benchmark for ischemic stroke lesion segmentation from multispectral MRI. Med. Image Anal. 35, 250–269 (2017)
Fischl, B., et al.: Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33(3), 341–355 (2002)
Long, J., Shelhamer, E., Darrell, T.: Fully convolutional networks for semantic segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 3431–3440 (2015)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: International Conference on Medical Image Computing and Computer-Assisted Intervention, pp. 234–241. Springer (2015)
Chen, L.C., Zhu, Y., Papandreou, G., Schroff, F., Adam, H.: Encoder-decoder with atrous separable convolution for semantic image segmentation. In: ECCV (2018)
Despotović, I., Goossens, B., Philips, W.: MRI segmentation of the human brain: challenges, methods, and applications. Comput. Math. Methods Med. 2015, 23 (2015)
Dolz, J., Massoptier, L., Vermandel, M.: Segmentation algorithms of subcortical brain structures on MRI for radiotherapy and radiosurgery: a survey. IRBM 36(4), 200–212 (2015)
Akkus, Z., Galimzianova, A., Hoogi, A., Rubin, D.L., Erickson, B.J.: Deep learning for brain MRI segmentation: state of the art and future directions. J. Digit. Imaging 30(4), 449–459 (2017)
Hoseini, F., Shahbahrami, A., Bayat, P.: An efficient implementation of deep convolutional neural networks for MRI segmentation. J. Digit. Imaging, 1–10 (2018)
Bernal, J., Kushibar, K., Asfaw, D.S., Valverde, S., Oliver, A., MartÃ, R., Lladó, X.: Deep convolutional neural networks for brain image analysis on magnetic resonance imaging: a review. arXiv preprint arXiv:1712.03747 (2017)
Lai, M.: Deep learning for medical image segmentation. arXiv preprint arXiv:1505.02000 (2015)
Roy, A.G., Conjeti, S., Navab, N., Wachinger, C.: QuickNAT: segmenting MRI neuroanatomy in 20 seconds. arXiv preprint arXiv:1801.04161 (2018)
Chollet, F.: Xception: deep learning with depthwise separable convolutions. arXiv preprint arXiv:1610.02357 (2017)
Szegedy, C., Vanhoucke, V., Ioffe, S., Shlens, J., Wojna, Z.: Rethinking the inception architecture for computer vision. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2818–2826 (2016)
Marcus, D.S., Fotenos, A.F., Csernansky, J.G., Morris, J.C., Buckner, R.L.: Open access series of imaging studies: longitudinal MRI data in nondemented and demented older adults. J. Cogn. Neurosci. 22(12), 2677–2684 (2010)
Jack Jr., C.R., Bernstein, M.A., Fox, N.C., Thompson, P., Alexander, G., Harvey, D., Borowski, B., Britson, P.J., Whitwell, J.L., Ward, C., et al.: The Alzheimer’s disease neuroimaging initiative (ADNI): MRI methods. J. Magn. Reson. Imaging: Official J. Int. Soc. Magn. Reson. Med. 27(4), 685–691 (2008)
Fischl, B., Sereno, M.I., Tootell, R.B., Dale, A.M.: High-resolution intersubject averaging and a coordinate system for the cortical surface. Hum. Brain Mapp. 8(4), 272–284 (1999)
Desikan, R.S., Ségonne, F., Fischl, B., Quinn, B.T., Dickerson, B.C., Blacker, D., Buckner, R.L., Dale, A.M., Maguire, R.P., Hyman, B.T., et al.: An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31(3), 968–980 (2006)
Mendrik, A.M., Vincken, K.L., Kuijf, H.J., Breeuwer, M., Bouvy, W.H., De Bresser, J., Alansary, A., De Bruijne, M., Carass, A., El-Baz, A., et al.: MRBrains challenge: online evaluation framework for brain image segmentation in 3T MRI scans. Comput. Intell. Neurosci. 2015, 1 (2015)
MRBrains18 challenge: Grand challenge on MR brain segmentation at MICCAI 2018. http://mrbrains18.isi.uu.nl
Tustison, N.J., Avants, B.B., Cook, P.A., Zheng, Y., Egan, A., Yushkevich, P.A., Gee, J.C.: N4ITK: improved N3 bias correction. IEEE Trans. Med. Imaging 29(6), 1310–1320 (2010)
Evans, A.C., Collins, D.L., Mills, S., Brown, E., Kelly, R., Peters, T.M.: 3D statistical neuroanatomical models from 305 MRI volumes. In: 1993 IEEE Conference Record Nuclear Science Symposium and Medical Imaging Conference, pp. 1813–1817. IEEE (1993)
Abadi, M., Agarwal, A., Barham, P., Brevdo, E., Chen, Z., Citro, C., Corrado, G.S., Davis, A., Dean, J., Devin, M., Ghemawat, S., Goodfellow, I., Harp, A., Irving, G., Isard, M., Jia, Y., Jozefowicz, R., Kaiser, L., Kudlur, M., Levenberg, J., Mané, D., Monga, R., Moore, S., Murray, D., Olah, C., Schuster, M., Shlens, J., Steiner, B., Sutskever, I., Talwar, K., Tucker, P., Vanhoucke, V., Vasudevan, V., Viégas, F., Vinyals, O., Warden, P., Wattenberg, M., Wicke, M., Yu, Y., Zheng, X.: TensorFlow: Large-scale machine learning on heterogeneous systems (2015). https://www.tensorflow.org/
Krähenbühl, P., Koltun, V.: Efficient inference in fully connected CRFs with Gaussian edge potentials. In: Advances in Neural Information Processing Systems, pp. 109–117 (2011)
Chen, L.C., Papandreou, G., Kokkinos, I., Murphy, K., Yuille, A.L.: Semantic image segmentation with deep convolutional nets and fully connected CRFs. arXiv preprint arXiv:1412.7062 (2014)
Chen, L.C., Papandreou, G., Kokkinos, I., Murphy, K., Yuille, A.L.: DeepLab: semantic image segmentation with deep convolutional nets, atrous convolution, and fully connected CRFs. IEEE Trans. Pattern Anal. Mach. Intell. 40(4), 834–848 (2018)
Pan, X., Shi, J., Luo, P., Wang, X., Tang, X.: Spatial as deep: Spatial CNN for traffic scene understanding. arXiv preprint arXiv:1712.06080 (2017)
Chen, J., Yang, L., Zhang, Y., Alber, M., Chen, D.Z.: Combining fully convolutional and recurrent neural networks for 3D biomedical image segmentation. In: Advances in Neural Information Processing Systems, pp. 3036–3044 (2016)
Visin, F., Ciccone, M., Romero, A., Kastner, K., Cho, K., Bengio, Y., Matteucci, M., Courville, A.: ReSeg: a recurrent neural network-based model for semantic segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition Workshops, pp. 41–48 (2016)
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Anand, A., Anand, N. (2020). Fast Brain Volumetric Segmentation from T1 MRI Scans. In: Arai, K., Kapoor, S. (eds) Advances in Computer Vision. CVC 2019. Advances in Intelligent Systems and Computing, vol 943. Springer, Cham. https://doi.org/10.1007/978-3-030-17795-9_30
Download citation
DOI: https://doi.org/10.1007/978-3-030-17795-9_30
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-17794-2
Online ISBN: 978-3-030-17795-9
eBook Packages: Intelligent Technologies and RoboticsIntelligent Technologies and Robotics (R0)