Abstract
Noncompaction cardiomyopathy (NCCM) is a rare cardiomyopathy characterized by prominent myocardial trabeculations and deep intertrabecular recesses in the left ventricular (LV) cavity. Due to its special phenotype, typical potential complications are heart failure, arrhythmias, and thromboembolic events. Thromboembolic events like stroke is a feared complication, and unfortunately not uncommon in NCCM patients. Cardiac emboli are theorized to result from thrombus formation within the intertrabecular recesses, especially in patients with reduced systolic function. Unfortunately, due to its rarity and relatively young disease entity, evidence-based recommendations for preventing thromboembolic events in NCCM have not been established. According to recent literature, atrial fibrillation (AF) is relatively common in patients with NCCM and therefore, oral anticoagulants, including vitamin K antagonists (VKA) and new oral anticoagulants (NOAC), seem to be reasonable to reduce thromboembolic rate. In case of a history of previous stroke and thromboembolism, VKA or NOAC use is according the current clinical insights beyond any doubt. In NCCM patient with an systolic dysfunction, but sinus rhythm, overall benefit of preventive oral anticoagulation should be yet demonstrated.
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Nemes, A. (2019). Prevalence and Prevention of Thromboembolic Events in Noncompaction Cardiomyopathy. In: Caliskan, K., Soliman, O., ten Cate, F. (eds) Noncompaction Cardiomyopathy. Springer, Cham. https://doi.org/10.1007/978-3-030-17720-1_6
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DOI: https://doi.org/10.1007/978-3-030-17720-1_6
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