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Continuum Models of Collective Cell Migration

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Book cover Cell Migrations: Causes and Functions

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1146))

Abstract

Collective cell migration plays a central role in tissue development, morphogenesis, wound repair and cancer progression. With the growing realization that physical forces mediate cell motility in development and physiology, a key biological question is how cells integrate molecular activities for force generation on multicellular scales. In this review we discuss recent advances in modeling collective cell migration using quantitative tools and approaches rooted in soft matter physics. We focus on theoretical models of cell aggregates as continuous active media, where the feedback between mechanical forces and regulatory biochemistry gives rise to rich collective dynamical behavior. This class of models provides a powerful predictive framework for the physiological dynamics that underlies many developmental processes, where cells need to collectively migrate like a viscous fluid to reach a target region, and then stiffen to support mechanical stresses and maintain tissue cohesion.

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Acknowledgements

SB acknowledges support from a Strategic Fellowship at the Institute for the Physics of Living Systems at UCL, UCL Global Engagement Fund, Royal Society Tata University Research Fellowship (URF\R1\180187), and Human Frontiers Science Program (HFSP RGY0073/2018). MCM was supported by the National Science Foundation at Syracuse University through award DMR-1609208 and at KITP under Grant PHY-1748958, and by the Simons Foundation through a Targeted Grant Award No. 342354. MCM thanks M. Czajkowski for useful discussions and the KITP for hospitality during completion of some of this work.

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Authors and Affiliations

  1. University College London, London, UK

    Shiladitya Banerjee

  2. University of California Santa Barbara, Santa Barbara, CA, USA

    M. Cristina Marchetti

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  1. Shiladitya Banerjee
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Correspondence to Shiladitya Banerjee .

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  1. Department of Environmental Science and Policy, Center for Complexity and Biosystems University of Milan, Milan, Italy

    Caterina A. M. La Porta

  2. Department of Physics, Center for Complexity and Biosystems University of Milan, Milan, Italy

    Stefano Zapperi

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Banerjee, S., Marchetti, M.C. (2019). Continuum Models of Collective Cell Migration. In: La Porta, C., Zapperi, S. (eds) Cell Migrations: Causes and Functions. Advances in Experimental Medicine and Biology, vol 1146. Springer, Cham. https://doi.org/10.1007/978-3-030-17593-1_4

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