Abstract
There is a multiplicity of drugs that can be used during the perioperative period. Each has indications and adverse reactions that must be appreciated. Broadly speaking, there are not contraindicated drugs in the neurosurgical setting; each one must be carefully appreciated according to the patient’s conditions and characteristics. Among the main drugs effects that must be considered in the neurosurgical patient are the cerebral blood flow and metabolic rate, the intracranial and arterial pressure and the CO2 reactivity. Only a rigorous balance between all of them in conjunction with the optimal perioperative management will provide the best possible outcome to the patients.
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Jackson WL. Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock?: a critical appraisal. Chest. 2005;127(3):707–9.
Lukins MB, Manninen PH. Hyperglycemia in patients administered dexamethasone for craniotomy. Anesth Analg. 2005;100:1129–33.
Martyn JA. Neuromuscular physiology and pharmacology. In: Miller R, editor. Miller’s anesthesia. 7th ed. Philadelphia: Elsevier Churchill Livingstone; 2010. p. 341–60.
McNamara J. Drugs effective in the therapy of epilepsies. In: Hardman JG, Limbird LE, editors. Goodman and Gilman’s the pharmacological basis of therapeutics. 10th ed. New York: McGraw-Hill; 2001.
Minton MD, Grosslight K, Stirt JA, et al. Increases in intracranial pressure from succinylcholine: prevention by prior nondepolarizing blockade. Anesthesiology. 1986;65(2):165–9.
Murphy GS, Szokol JW, Marymont JH, et al. Intraoperative acceleromyographic monitoring reduces the risk of residual neuromuscular blockade and adverse respiratory events in the post anesthesia care unit. Anesthesiology. 2008;109(3):389–98.
Pasternak J, McGregor D, Lanier W, et al. Effect of nitrous oxide use on long-term neurologic and neuropsychological outcome in patients who received temporary proximal artery occlusion during cerebral aneurysm clipping surgery. Anesthesiology. 2009;110:563–73.
Patel MP, Drummond JC. Cerebral physiology and the effects of anesthetic drugs. In: Miller RD, editor. Miller’s anesthesia. 7th ed. Philadelphia: Elsevier Churchill Livingstone; 2010. p. 305–40.
Pfister D, Strebel SP, Steiner LA. Effects of catecholamines on cerebral blood vessels in patients with traumatic brain injury. Eur J Anaesthesiol. 2008;42(Suppl):98–103.
Reves J, Glass P, et al. Intravenous anesthetics. In: Miller R, editor. Miller’s anesthesia. 7th ed. Philadelphia: Elsevier Churchill Livingstone; 2010. p. 719–68.
Rozet I, Tontisirin N, Saipin M, et al. Effect of equiosmolar solutions of mannitol versus hypertonic saline on intraoperative brain relaxation and electrolyte balance. Anesthesiology. 2007;107:697–704.
Talbert RL. The challenge of blood pressure management in neurologic emergencies. Pharmacotherapy. 2006;26(8 Pt 2):123S–30S.
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Trement IW. Antiepileptic drugs for preventing seizures in people with brain tumors. Cochrane Database Syst Rev. 2008;(2):CD004424.
White H, Cook D, Venkatesh B. The role of hypertonic saline in neurotrauma. Eur J Anaesthesiol. 2008;42(Suppl):104–9.
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Delfino, A.E., Tala, J.B., Muñoz, H.R. (2020). Perioperative Pharmacotherapy in Neurosurgery: Risk Assessment and Planning. In: Brambrink, A., Kirsch, J. (eds) Essentials of Neurosurgical Anesthesia & Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-030-17410-1_12
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DOI: https://doi.org/10.1007/978-3-030-17410-1_12
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