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Head and Neck Stereotactic Body Radiation Therapy

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Abstract

Stereotactic body radiation therapy (SBRT) is an emerging technique for treatment of primary and recurrent head and neck cancers in patients unsuited for conventional management strategies. SBRT has demonstrated favourable responses and tolerable toxicity profiles for patients with unresectable primary disease or recurrent tumours. Severe toxicity risk remains, with carotid blowout syndrome a unique concern despite strategies to minimize risk.

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References

  1. Argiris A, Karamouzis MV, Raben D, Ferris RL. Head and neck cancer. Lancet. 2008;371(9625):1695–709.

    Article  CAS  Google Scholar 

  2. Goodwin WJ Jr. Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: when do the ends justify the means? Laryngoscope. 2000;110(3 II):1–18.

    Article  Google Scholar 

  3. O’Sullivan B, Huang SH, Siu LL, Waldron J, Zhao H, Perez-Ordonez B, et al. Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol. 2013;31(5):543–50.

    Article  Google Scholar 

  4. Baliga S, Kabarriti R, Ohri N, Haynes-Lewis H, Yaparpalvi R, Kalnicki S, et al. Stereotactic body radiotherapy for recurrent head and neck cancer: a critical review. Head Neck. 2017 Mar;39(3):595–601.

    Article  Google Scholar 

  5. Ling DC, Vargo JA, Heron DE. Stereotactic body radiation therapy for recurrent head and neck cancer. Cancer J. 2016;22(4):302–6.

    Article  CAS  Google Scholar 

  6. Karam I, Poon I, Lee J, Liu S, Higgins K, Enepekides D, et al. Stereotactic body radiotherapy for head and neck cancer: an addition to the armamentarium against head and neck cancer. Future Oncol. 2015;11(21):2937–47.

    Article  CAS  Google Scholar 

  7. Karam I, Yao M, Heron DE, Poon I, Koyfman SA, Yom SS, et al. Survey of current practices from the International Stereotactic Body Radiotherapy Consortium (ISBRTC) for head and neck cancers. Future Oncol. 2017;13(7):603–13.

    Article  CAS  Google Scholar 

  8. Vargo JA, Ward MC, Caudell JJ, Riaz N, Dunlap NE, Isrow D, et al. A multi-institutional comparison of SBRT and IMRT for definitive reirradiation of recurrent or second primary head and neck cancer. Int J Radiat Oncol Biol Phys. 2018;100(3):595–605.

    Article  Google Scholar 

  9. Rwigema JC, Heron DE, Ferris RL, Gibson M, Quinn A, Yang Y, et al. Fractionated stereotactic body radiation therapy in the treatment of previously-irradiated recurrent head and neck carcinoma: updated report of the University of Pittsburgh experience. Am J Clin Oncol. 2010;33(3):286–93.

    PubMed  Google Scholar 

  10. Yamazaki H, Ogita M, Himei K, Nakamura S, Yoshida K, Kotsuma T, et al. Hypofractionated stereotactic radiotherapy using CyberKnife as a boost treatment for head and neck cancer, a multi-institutional survey: impact of planning target volume. Anticancer Res. 2014;34(10):5755.

    PubMed  Google Scholar 

  11. Yamazaki H, Ogita M, Himei K, Nakamura S, Kotsuma T, Yoshida K, et al. Carotid blowout syndrome in pharyngeal cancer patients treated by hypofractionated stereotactic re-irradiation using CyberKnife: a multi-institutional matched-cohort analysis. Radiother Oncol. 2015;115(1):67–71.

    Article  Google Scholar 

  12. Syrigos KN, Karachalios D, Karapanagiotou EM, Nutting CM, Manolopoulos L, Harrington KJ. Head and neck cancer in the elderly: an overview on the treatment modalities. Cancer Treat Rev. 2009;35(3):237–45.

    Article  Google Scholar 

  13. Chaturvedi AK, Anderson WF, Lortet-Tieulent J, Paula Curado M, Ferlay J, Franceschi S, et al. Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers. J Clin Oncol. 2013;31(36):4550–9.

    Article  Google Scholar 

  14. Huang SH, O’Sullivan B, Waldron J, Lockwood G, Bayley A, Kim J, et al. Patterns of care in elderly head-and-neck cancer radiation oncology patients: a single-center cohort study. Int J Radiat Oncol Biol Phys. 2011;79(1):46–51.

    Article  Google Scholar 

  15. Monnier L, Touboul E, Durdux C, Lang P, St Guily JL, Huguet F. Hypofractionated palliative radiotherapy for advanced head and neck cancer: the IHF2SQ regimen. Head Neck. 2013;35(12):1683–8.

    Article  Google Scholar 

  16. Bonomo P, Desideri I, Loi M, Lo Russo M, Olmetto E, Maragna V, et al. Elderly patients affected by head and neck squamous cell carcinoma unfit for standard curative treatment: is de-intensified, hypofractionated radiotherapy a feasible strategy? Oral Oncol. 2017;74:142–7.

    Article  Google Scholar 

  17. Corry J, Peters LJ, Costa ID, Milner AD, Fawns H, Rischin D, et al. The ‘QUAD SHOT’—a phase II study of palliative radiotherapy for incurable head and neck cancer. Radiother Oncol. 2005;77(2):137–42.

    Article  Google Scholar 

  18. Teckie S, Lok BH, Rao S, Gutiontov SI, Yamada Y, Berry SL, et al. High-dose hypofractionated radiotherapy is effective and safe for tumors in the head-and-neck. Oral Oncol. 2016;60:74–80.

    Article  Google Scholar 

  19. Stevens CM, Huang SH, Fung S, Bayley AJ, Cho JB, Cummings BJ, et al. Retrospective study of palliative radiotherapy in newly diagnosed head and neck carcinoma. Int J Radiat Oncol Biol Phys. 2011;81(4):958–63.

    Article  Google Scholar 

  20. Siddiqui F, Patel M, Khan M, McLean S, Dragovic J, Jin J, et al. Stereotactic body radiation therapy for primary, recurrent, and metastatic tumors in the head-and-neck region. Int J Radiat Oncol Biol Phys. 2009;74(4):1047–53.

    Article  Google Scholar 

  21. Kodani N, Yamazaki H, Tsubokura T, Shiomi H, Kobayashi K, Nishimura T, et al. Stereotactic body radiation therapy for head and neck tumor: disease control and morbidity outcomes. J Radiat Res. 2011;52(1):24–31.

    Article  Google Scholar 

  22. Kawaguchi K, Sato K, Yamada H, Horie A, Nomura T, Iketani S, et al. Stereotactic radiosurgery in combination with chemotherapy as primary treatment for head and neck cancer. J Oral Maxillofac Surg. 2012;70(2):461–72.

    Article  Google Scholar 

  23. Vargo JA, Ferris RL, Clump DA, Heron DE. Stereotactic body radiotherapy as primary treatment for elderly patients with medically inoperable head and neck cancer. Front Oncol. 2014;4:214.

    Article  Google Scholar 

  24. Khan L, Tjong M, Raziee H, Lee J, Erler D, Chin L, et al. Role of stereotactic body radiotherapy for symptom control in head and neck cancer patients. Support Care Cancer. 2015;23(4):1099.

    Article  Google Scholar 

  25. Chen HHW, Tsai S, Wang M, Wu Y, Hsueh W, Yang M, et al. Experience in fractionated stereotactic body radiation therapy boost for newly diagnosed nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2006;66(5):1408–14.

    Article  Google Scholar 

  26. Hara W, Loo BW, Goffinet DR, Chang SD, Adler JR, Pinto HA, et al. Excellent local control with stereotactic radiotherapy boost after external beam radiotherapy in patients with nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2008;71(2):393–400.

    Article  Google Scholar 

  27. Al-Mamgani A, Tans L, Teguh DN, van Rooij P, Zwijnenburg EM, Levendag PC. Stereotactic body radiotherapy: a promising treatment option for the boost of oropharyngeal cancers not suitable for brachytherapy: a single-institutional experience. Int J Radiat Oncol Biol Phys. 2012;82(4):1494–500.

    Article  Google Scholar 

  28. Lee DS, Kim YS, Cheon JS, Song JH, Son SH, Jang JS, et al. Long-term outcome and toxicity of hypofractionated stereotactic body radiotherapy as a boost treatment for head and neck cancer: the importance of boost volume assessment. Radiat Oncol. 2012;7(1):85.

    Article  Google Scholar 

  29. Ghaly M, Halthore A, Antone J, Zhang H, Cohen J, Sachs H, et al. Dose-escalated stereotactic radiosurgery (SRS) boost for unfavorable locally advanced oropharyngeal cancer: phase I/II trial. Int J Radiat Oncol Biol Phys. 90(1):S122.

    Google Scholar 

  30. Patel PR, Salama JK. Reirradiation for recurrent head and neck cancer. Expert Rev Anticancer Ther. 2012;12(9):1177–89.

    Article  CAS  Google Scholar 

  31. McDonald MW, Lawson J, Garg MK, Quon H, Ridge JA, Saba N, et al. ACR appropriateness criteria retreatment of recurrent head and neck cancer after prior definitive radiation: Expert panel on radiation oncology-head and neck cancer. Int J Radiat Oncol Biol Phys. 2011;80(5):1292–8.

    Article  Google Scholar 

  32. Tortochaux J, Tao Y, Tournay E, Lapeyre M, Lesaunier F, Bardet E, et al. Randomized phase III trial (GORTEC 98-03) comparing re-irradiation plus chemotherapy versus methotrexate in patients with recurrent or a second primary head and neck squamous cell carcinoma, treated with a palliative intent. Radiother Oncol. 2011;100(1):70–5.

    Article  CAS  Google Scholar 

  33. Lartigau EF, Tresch E, Thariat J, Graff P, Coche-Dequeant B, Benezery K, et al. Multi institutional phase II study of concomitant stereotactic reirradiation and cetuximab for recurrent head and neck cancer. Radiother Oncol. 2013;109(2):281–5.

    Article  CAS  Google Scholar 

  34. Langer CJ, Harris J, Horwitz EM, Nicolaou N, Kies M, Curran W, et al. Phase II study of low-dose paclitaxel and cisplatin in combination with split-course concomitant twice-daily reirradiation in recurrent squamous cell carcinoma of the head and neck: results of radiation therapy oncology group protocol 9911. J Clin Oncol. 2007;25(30):4800–5.

    Article  CAS  Google Scholar 

  35. Spencer SA, Harris J, Wheeler RH, Machtay M, Schultz C, Spanos W, et al. Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. Head Neck. 2008;30(3):281–8.

    Article  Google Scholar 

  36. Voynov G, Heron DE, Burton S, Grandis J, Quinn A, Ferris R, et al. Frameless stereotactic radiosurgery for recurrent head and neck carcinoma. Technol Cancer Res Treat. 2006;5(5):529–35.

    Article  Google Scholar 

  37. Roh K, Jang J, Jang H, Kim M, Kim B, Kim Y, et al. Fractionated stereotactic radiotherapy as reirradiation for locally recurrent head and neck cancer. Int J Radiat Oncol Biol Phys. 2009;74(5):1348–55.

    Article  Google Scholar 

  38. Heron DE, Ferris RL, Karamouzis M, Andrade RS, Deeb EL, Burton S, et al. Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a phase I dose-escalation trial. Int J Radiat Oncol Biol Phys. 2009;75(5):1493–500.

    Article  Google Scholar 

  39. Rwigema JCM, Heron DE, Ferris RL, Andrade RS, Gibson MK, Yang Y, et al. The impact of tumor volume and radiotherapy dose on outcome in previously irradiated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapy. Am J Clin Oncol. 2011;34(4):372–9.

    Article  Google Scholar 

  40. Unger KR, Lominska CE, Deeken JF, Davidson BJ, Newkirk KA, Gagnon GJ, et al. Fractionated stereotactic radiosurgery for reirradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2010;77(5):1411–9.

    Article  Google Scholar 

  41. Cengiz M, Özyiğit G, Yazici G, Doğan A, Yildiz F, Zorlu F, et al. Salvage reirradiation with stereotactic body radiotherapy for locally recurrent head-and-neck tumors. Int J Radiat Oncol Biol Phys. 2011;81(1):104–9.

    Article  Google Scholar 

  42. Ozyigit G, Cengiz M, Yazici G, Yildiz D, Yildiz F, Gurkaynak M, et al. A retrospective comparison of robotic stereotactic body radiotherapy and three-dimensional conformal radiotherapy for the reirradiation of locally recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2011;81(4):e268.

    Article  Google Scholar 

  43. Vargo JA, Wegner RE, Heron DE, Ferris RL, Rwigema JM, Quinn A, et al. Stereotactic body radiation therapy for locally recurrent, previously irradiated nonsquamous cell cancers of the head and neck. Head Neck. 2012;34(8):1153–61.

    Article  Google Scholar 

  44. Comet B, Kramar A, Faivre-Pierret M, Dewas S, Coche-Dequeant B, Degardin M, et al. Salvage stereotactic reirradiation with or without cetuximab for locally recurrent head-and-neck cancer: a feasibility study. Int J Radiat Oncol Biol Phys. 2012;84(1):203–9.

    Article  Google Scholar 

  45. Vargo JA, Ferris RL, Ohr J, Clump DA, Davis KS, Duvvuri U, et al. A prospective phase 2 trial of reirradiation with stereotactic body radiation therapy plus cetuximab in patients with previously irradiated recurrent squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 2015;91(3):480–8.

    Article  Google Scholar 

  46. Bonner JA, Harari PM, Giralt J. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354:567.

    Article  CAS  Google Scholar 

  47. Gebhardt BJ, Vargo JA, Ling D, Jones B, Mohney M, Clump DA, et al. Carotid dosimetry and the risk of carotid blowout syndrome following re-irradiation with head and neck stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys. 2018;101(1):195–200.

    Article  Google Scholar 

  48. Kong L, Hu J, Guan X, Gao J, Lu R, Lu JJ. Phase I/II trial evaluating carbon ion radiotherapy for salvaging treatment of locally recurrent nasopharyngeal carcinoma. J Cancer. 2016;7(7):774–83.

    Article  CAS  Google Scholar 

  49. Romesser PB, Cahlon O, Scher ED, Hug EB, Sine K, Deselm C, et al. Proton beam reirradiation for recurrent head and neck cancer: multi-institutional report on feasibility and early outcomes. Int J Radiat Oncol Biol Phys. 2016;95(1):386–95.

    Article  Google Scholar 

  50. McDonald MW, Zolali-Meybodi O, Lehnert SJ, Estabrook NC, Liu Y, Cohen-Gadol AA, et al. Reirradiation of recurrent and second primary head and neck cancer with proton therapy. Int J Radiat Oncol Biol Phys. 2016;96(4):808–19.

    Article  Google Scholar 

  51. Ling DC, Vargo JA, Ferris RL, Ohr J, Clump DA, Yau W-W, et al. Risk of severe toxicity according to site of recurrence in patients treated with stereotactic body radiation therapy for recurrent head and neck cancer. Int J Radiat Oncol Biol Phys. 2016;95(3):973–80.

    Article  Google Scholar 

  52. Liang NL, Guedes BD, Duvvuri U, Singh MJ, Chaer RA, Makaroun MS, et al. Outcomes of interventions for carotid blowout syndrome in patients with head and neck cancer. J Vasc Surg. 2016;63(6):1525–30.

    Article  Google Scholar 

  53. Yazici G, Sanlı TY, Cengiz M, Yuce D, Gultekin M, Hurmuz P, et al. A simple strategy to decrease fatal carotid blowout syndrome after stereotactic body reirradiation for recurrent head and neck cancers. Radiat Oncol. 2013;8(1):242.

    Article  Google Scholar 

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Correspondence to Irene Karam .

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Lang, P., Poon, I., Chin, L., Karam, I. (2019). Head and Neck Stereotactic Body Radiation Therapy. In: Trifiletti, D., Chao, S., Sahgal, A., Sheehan, J. (eds) Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-16924-4_27

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  • DOI: https://doi.org/10.1007/978-3-030-16924-4_27

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