Abstract
Most of the studies on cutaneous wound healing are focused on epidermal closure. This is obviously important, as the epidermis constitutes the main barrier that separates the inner organism from the environment. However, dermal remodeling is key to achieve long-lasting healing of the area that was originally wounded. In this chapter, we summarize what is known on the stromal components that strongly influence the outcome of healing and postulate that dedifferentiation of stably differentiated cells plays a major role in the initial response to wounding, as well as in long-term wound remodeling. Specifically, we explore the available evidence implicating skin pericytes, endothelial cells, Schwann cells, and macrophages as major players in a complex symphony of cellular plasticity and signaling events whose balance will promote healing (by tissue regeneration or repair) or fibrosis.
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Acknowledgments
Writing of this chapter was supported by grants from Instituto de Salud Carlos III (PI13/02172; PI16/01430; AC17/00012), co-funded by the European Union (ERDF/ESF, “Investing in your future”; and Eracosysmed/H2020 Grant Agreement No. 643271). HI received a studentship from the Department of Education, University and Research of the Basque Government (PRE2013-1-1068).
A tribute is given to Dr. Shunichi Morikawa. From the right to the left, the two co-first authors of this chapter, Dr. Haizea Iribar and Dr. Shunichi Morikawa, and his wife, celebrating Japanese culture
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This chapter is dedicated to the memory of the late Dr. Shunichi Morikawa, an original thinker and pioneering scientist who largely increased our current understanding of the role of pericytes in cutaneous wound healing.
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Morikawa, S., Iribar, H., Gutiérrez-Rivera, A., Ezaki, T., Izeta, A. (2019). Pericytes in Cutaneous Wound Healing. In: Birbrair, A. (eds) Pericyte Biology in Disease. Advances in Experimental Medicine and Biology, vol 1147. Springer, Cham. https://doi.org/10.1007/978-3-030-16908-4_1
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