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Mesothelioma pp 99–122Cite as

Pathological Diagnosis of Mesothelioma

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Abstract

The diagnosis of mesothelioma is one of the most difficult challenges faced by pathologists. Its histologic diagnosis is stepwise and should be based on morphological assessment, associated with clinical and radiological findings, and supported by immunohistochemistry as well as more recent molecular tests. This neoplasm displays a wide variety of histologic patterns and the major dilemmas consist in differential diagnosis with benign mesothelial proliferations and other mimicking malignant tumors.

The histological findings of mesothelioma could facilitate its diagnosis and provide important prognostic information. The immunohistochemical approach should lie on the application of a panel including positive (mesothelial-related) and negative markers, which should be selected on the basis of morphology and clinical information. In challenging cases, molecular markers could help distinguish between benign and malignant mesothelial proliferations.

This chapter is an update of the morphological, immunohistochemical, and molecular features, with particular regard to diffuse malignant mesothelioma diagnosis.

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Authors and Affiliations

  1. Department of Surgical, Medical, Molecular Pathology, and Critical Area, University of Pisa, Pisa, Italy

    Gabriella Fontanini

  2. Unit of Pathological Anatomy, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

    Greta Alì & Rossella Bruno

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  1. Gabriella Fontanini
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  2. Greta Alì
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  3. Rossella Bruno
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Correspondence to Gabriella Fontanini .

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  1. Department of Medical Oncology, Humanitas Gavazzeni Hospital, Bergamo, Italy

    Giovanni Luca Ceresoli

  2. Scientific Direction, Humanitas Gavazzeni Hospital, Bergamo, Italy

    Emilio Bombardieri

  3. Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy

    Maurizio D'Incalci

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Fontanini, G., Alì, G., Bruno, R. (2019). Pathological Diagnosis of Mesothelioma. In: Ceresoli, G., Bombardieri, E., D'Incalci, M. (eds) Mesothelioma. Springer, Cham. https://doi.org/10.1007/978-3-030-16884-1_7

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