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Breast-Conserving Therapy: Hypofractionated and Conventional Whole-Breast Irradiation and Accelerated Partial-Breast Irradiation

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Breast Disease

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Abstract

Breast irradiation after breast-conserving surgery (BCS) is an essential component of breast conservation therapy for maximizing local control and overall survival. The most widely used fractionation regimen until recently was 1.8- to 2-Gy daily fractions for a total of 45–50 Gy to the whole breast over 5 weeks with or without a boost to the surgical bed. However, a new optimal dose and fractionation schedule for radiation therapy after BCS has been defined recently. There is renewed interest in hypofractionation for whole-breast irradiation (WBI), and this approach has important practical advantages and biological implications. The convenience of this method may facilitate patient acceptance and compliance with radiation therapy. Irradiating only the tumor-bearing quadrant of the breast in one to ten fractions instead of irradiating the whole breast after BCS has also increased in popularity recently.

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Authors and Affiliations

  1. Radiation Oncology, Medicana International Hospital, Istanbul, Turkey

    Fusun Tokatlı

  2. Department of Radiation Oncology, Florence Nightingale Hospital, Istanbul, Turkey

    Maktav Dincer

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  1. Fusun Tokatlı
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  2. Maktav Dincer
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Correspondence to Maktav Dincer .

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Editors and Affiliations

  1. Oncology Institute, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey

    Adnan Aydiner

  2. Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey

    Abdullah Igci

  3. Division of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Magee-Women’s Hospital of UPMC, Pittsburgh, PA, USA

    Atilla Soran

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Tokatlı, F., Dincer, M. (2019). Breast-Conserving Therapy: Hypofractionated and Conventional Whole-Breast Irradiation and Accelerated Partial-Breast Irradiation. In: Aydiner, A., Igci, A., Soran, A. (eds) Breast Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-16792-9_12

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  • DOI: https://doi.org/10.1007/978-3-030-16792-9_12

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