Abstract
Proctocolectomy and creation of an ileal pouch-anal anastomosis (IPAA), first described by Parks and Nicholls, is the preferred and most commonly performed surgical procedure for patients requiring resection of the entire large intestine provided they demonstrate good sphincter function and lack risk factors for postoperative complications or dysfunction. The operation was initially developed for patients with ulcerative colitis or familial adenomatous polyposis to preserve the normal route of defecation and avoid the need for a permanent stoma while ensuring acceptable functional results and satisfactory patient-reported quality of life.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Parks AG, Nicholls RJ. Proctocolectomy without ileostomy for ulcerative colitis. Br Med J. 1978;2(6130):85–8.
Magro F, Gionchetti P, Eliakim R, Ardizzone S, Armuzzi A, Barreiro-de Acosta M, et al. Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: Definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders. J Crohns Colitis. 2017;11:649–70.
Panis Y, Poupard B, Nemeth J, et al. Ileal pouch-anal anastomosis for Crohn’s disease. Lancet. 1996;347:854–7.
Joyce MR, Fazio VW. Can ileal pouch anal anastomosis be used in Crohn’s disease? Adv Surg. 2009;43:111–37.
Bemelman WA, Warusavitarne J, Sampietro GM, et al. ECCO-ESCP consensus on surgery for Crohn’s Disease. J Crohns Colitis. 2018;12:1–16.
Lightner AL, Dattani S, Dozois EJ, Moncrief SB, Pemberton JH, Mathis KL. Pouch excision: indications and outcomes. Color Dis. 2017;19(10):912–6.. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28387059
Amiot A, Gornet JM, Baudry C, Munoz-Bongrand N, Auger M, Simon M, Allez M, Cattan P, Sarfati E, Lemann M. Crohn’s disease recurrence after total proctocolectomy with definitive ileostomy. Dig Liver Dis. 2011;43:698–702.
Peyregne V, Francois Y, Gilly FN, Descos JL, Flourie B, Vignal J. Outcome of ileal pouch after secondary diagnosis of Crohn’s disease. Int J Color Dis. 2000;15:49–53.
Brown CJ, Maclean AR, Cohen Z, Macrae HM, O’Connor BI, McLeod RS. Crohn’s disease and indeterminate colitis and the ileal pouch-anal anastomosis: outcomes and patterns of failure. Dis Colon Rectum. 2005;48(8):1542–9.
de Oca J, Sanchez-Santos R, Rague JM, et al. Long-term results of ileal pouch-anal anastomosis in Crohn’s disease. Inflamm Bowel Dis. 2003;9:171–5.
Hyman NH, Fazio VW, Tuckson W’B, Lavery IC. Consequences of ileal pouch-anal anastomosis for Crohn’s disease. Dis Colon Rectum. 1991;34:653–7.
Grobler SP, Hosie KB, Affie E, et al. Outcome of restorative proctocolectomy when the diagnosis is suggestive of Crohn’s disease. Gut. 1993;34:1384–8.
Sagar PM, Dozois RR, Wolff BG. Long-term results of ileal pouch-anal anastomosis in patients with Crohn‘s disease. Dis Colon Rectum. 1996;39:893–8.
Braveman JM, Schoetz DJ Jr, Marcello PW, et al. The fate of the ileal pouch in patients developing Crohn’s disease. Dis Colon Rectum. 2004;47:1613.
Tekkis PP, Heriot AG, Smith O, Smith JJ, Windsor AC, Nicholls RJ. Long-term outcomes of restorative proctocolectomy for Crohn’s disease and indeterminate colitis. Color Dis. 2005;7:218–23.
American College of Gastroenterology Chronic Constipation Task Force. An evidence-based approach to the management of chronic constipation in North America. Am J Gastroenterol. 2005;100 Suppl. 1:S1–4.
Milonakis E, Allan RN, Keighley MR. How does pouch construction for a final diagnosis of Crohn’s disease compare with ileoproctostomy for established Crohn’s proctocolitis? Dis Colon Rectum. 2001;44:1137–42.
Regimbeau JM, Panis Y, Pocard M, et al. Long-term results of ileal pouch-anal anastomosis for colorectal Crohn’s disease. Dis Colon Rectum. 2001;44:769–78.
Melton GB, Fazio VW, Kiran RP, et al. Long-term outcomes with ileal pouchanal anastomosis and Crohn’s disease: pouch retention and implications of delayed diagnosis. Ann Surg. 2008;248:608–16.
Shen B, Patel S, Lian L. Natural History of Crohn’s disease in patients who underwent intentional restorative proctocolectomy with ileal pouch-anal anastomosis. Aliment Pharmacol Ther. 2010;31:745–53.
Grucela AL, Bauer JJ, Gorfine SS, et al. Outcome and long-term function of restorative proctocolectomy for Crohn’s disease: comparison to patients with ulcerative colitis. Color Dis. 2011;13:426–30.
Fazio VW, Kiran RP, Remzi FH, Coffey JC, Heneghan HM, Kirat HT, et al. Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients. Ann Surg. 2013;257:679–85.
Le Q, Melmed G, Dubinsky M, et al. Surgical outcome of ileal pouch-anal anastomosis when used intentionally for well-defined Crohn’s disease. Inflamm Bowel Dis. 2013;19:30–6.
Delaney CP, Fazio VW, Remzi FH, et al. Prospective, age-related analysis of surgical results, functional outcome, and quality of life after ileal pouch-anal anastomosis. Ann Surg. 2003;238:221–8.
Yamamoto T, Bain IM, Allan RN, Keighley MRB. Persistent perineal sinus after proctocolectomy for Crohn’s disease. Dis Colon Rectum. 1999;42:96–101.
Li W, Stocchi L, Elagili F, Kiran RP, Strong SA. Healing of perineal wound after proctectomy in Crohn’s disease patients: only preoperative perineal sepsis predict poor outcome. Tech Coloproctol. 2017;21:715–20.
Murphy P, Khot Z, Vogt K, et al. Quality of life after total proctocolectomy with ileostomy or IPAA: a systematic review. Dis Colon Rectum. 2015;58:899–908.
Pellino G, Sciaudone G, Selvaggi F, et al. Delayed diagnosis is influenced by the clinical pattern of Crohn’s disease and affects treatment outcomes and quality of life in the long term: a cross-sectional study of 361 patients in Southern Italy. Eur J Gastroenterol Hepatol. 2015;27:175–81.
Dignass A, Van Assche G, Lindsay JO, et al. European Crohn’s and Colitis Organisation (ECCO). The second European evidence-based consensus on the diagnosis and management of Crohn’s disease: current management. J Crohns Colitis. 2010;4(1):28–62.
Weaver KN, Gregory M, Syal G, et al. Ustekinumab is effective for the treatment of Crohn’s disease of the pouch in a multicenter cohort. Inflamm Bowel Dis. 2019;25(4):767–74.
Malik T, Lee MJ, Harikrishnan AB. The incidence of stoma related morbidity—a systematic review of randomised controlled trials. Ann R Coll Surg Engl. 2018;100(7):501–8.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Gallo, G., Bemelman, W.A. (2019). Role of IPAA for Crohn’s Disease. In: Hyman, N., Fleshner, P., Strong, S. (eds) Mastery of IBD Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-16755-4_15
Download citation
DOI: https://doi.org/10.1007/978-3-030-16755-4_15
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-16754-7
Online ISBN: 978-3-030-16755-4
eBook Packages: MedicineMedicine (R0)