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Intranasal Delivery of Drugs for Ischemic Stroke Treatment: Targeting IL-17A

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Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Stroke is the second most common cause of death worldwide and a major cause of disability. However, uncertainty surrounds the efficacy and safety of peripheral or intracerebroventricular drug administration for stroke treatment. Intranasal delivery is emerging as a noninvasive option for delivering drugs to the central nervous system with minimal peripheral exposure. Use of the intranasal route could potentially reduce systemic exposure and side effects. Intranasal delivery provides rapid onset that occurs within minutes. Additionally, this method facilitates the delivery of large and/or charged molecules, which fail to effectively cross the blood-brain barrier. We have shown previously that intranasal delivery of exogenous interleukin-17A (IL-17A) promotes the survival, neuronal differentiation, and subsequent synaptogenesis of neural precursor cells in the subventricular zone during stroke recovery, as well as spontaneous recovery and angiogenesis. Therefore, although IL-17A is well-known for contributing to damage in acute ischemic stroke, it might also mediate neurorepair and spontaneous recovery after stroke when delivered intranasally.

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Author information

Authors and Affiliations

  1. Department of Anesthesia, Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China

    Yun Lin

  2. Department of Critical Care Medicine, Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China

    Jiancheng Zhang

  3. Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Jian Wang

Authors
  1. Yun Lin
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  2. Jiancheng Zhang
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  3. Jian Wang
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Corresponding author

Correspondence to Jian Wang .

Editor information

Editors and Affiliations

  1. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA

    Jun Chen

  2. Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Jian Wang

  3. Departments of Anesthesiology and Neurology, Emory University School of Medicine, Atlanta, GA, USA

    Ling Wei

  4. Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA

    John H. Zhang

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Lin, Y., Zhang, J., Wang, J. (2019). Intranasal Delivery of Drugs for Ischemic Stroke Treatment: Targeting IL-17A. In: Chen, J., Wang, J., Wei, L., Zhang, J. (eds) Therapeutic Intranasal Delivery for Stroke and Neurological Disorders. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-030-16715-8_8

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  • DOI: https://doi.org/10.1007/978-3-030-16715-8_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-16713-4

  • Online ISBN: 978-3-030-16715-8

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