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Transnasal Induction of Therapeutic Hypothermia for Neuroprotection

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Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Effective control of core body temperature and producing hypothermia is the standard of care for comatose patients with cardiac arrest and also in neurogenic fevers. Nasopharyngeal space has been a region of great interest to induce therapeutic hypothermia for a long time. This is primarily due to the favorable location of the nasal heat exchanger directly beneath the brain, the main target for hypothermia. This chapter focuses on achieving therapeutic hypothermia of the brain and core body temperature by using transnasal dry air.

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Acknowledgements

This work was supported by a NIH SBIR grant to Harikrishna Tandri (1 R44 HL108542-01A1).

Disclosures

Dr. Tandri holds patents for transnasal cooling and invented the transnasal dry air cooling device (CoolStat).

Author information

Authors and Affiliations

  1. Center for Cardiac Innovations, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Raghuram Chava & Harikrishna Tandri

Authors
  1. Raghuram Chava
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  2. Harikrishna Tandri
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Corresponding author

Correspondence to Harikrishna Tandri .

Editor information

Editors and Affiliations

  1. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA

    Jun Chen

  2. Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Jian Wang

  3. Departments of Anesthesiology and Neurology, Emory University School of Medicine, Atlanta, GA, USA

    Ling Wei

  4. Department of Physiology, Loma Linda University School of Medicine, Loma Linda, CA, USA

    John H. Zhang

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Chava, R., Tandri, H. (2019). Transnasal Induction of Therapeutic Hypothermia for Neuroprotection. In: Chen, J., Wang, J., Wei, L., Zhang, J. (eds) Therapeutic Intranasal Delivery for Stroke and Neurological Disorders. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-030-16715-8_1

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  • DOI: https://doi.org/10.1007/978-3-030-16715-8_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-16713-4

  • Online ISBN: 978-3-030-16715-8

  • eBook Packages: MedicineMedicine (R0)

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