Abstract
Micro-computed tomography (micro-CT) has its applications in various areas including bone structures, geological studies, and medical devices. This review focuses on cardiovascular applications of micro-CT and presents some of our cardiovascular device scans and animal model scans with corresponding reconstructions. After scanning with micro-CT, a 3D geometry is obtained, and a computational fluid dynamics (CFD) model can be studied to examine the properties of the desired devices or animal models. This review also compares micro-CT with other imaging modalities and discusses its advantages and disadvantages. Our findings show that micro-CT is highly suitable for biomedical device scans since it requires very little preparation (if any), no coating or vacuum treatment. Moreover, it offers resolution down to the submicron level of the sample’s morphology and internal microstructure which permits progressive imaging from the entire body down to the tissue level.
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References
Boerckel JD, Mason DE, McDermott AM, Alsberg E. Microcomputed tomography: approaches and applications in bioengineering. Stem Cell Res Therapy. 2014;5(6):144.
D’Onofrio C, et al. Three dimensional computational model of a blood oxygenator reconstructed from micro-CT scans. Med Eng Phys. 2017;47:190–7.
Pierce EL, Bloodworth CH, Naran A, Easley TF, Jensen MO, Yoganathan AP. Novel method to track soft tissue deformation by micro-computed tomography: application to the mitral valve. Ann Biomed Eng. 2016;44(7):2273–81.
Kim JS, Min J, Recknagel AK, Riccio M, Butcher J. Quantitative three-dimensional analysis of embryonic chick morphogenesis via microcomputed tomography. Anat Rec (Hoboken). 2011;294(1):1–10.
Wang Y, et al. Aortic arch morphogenesis and flow modeling in the chick embryo. Ann Biomed Eng. 2009;37(6):1069–81.
Ritman EL. Micro-computed tomography of the lungs and pulmonary-vascular system. Proc Am Thorac Soc. 2005;2(6):477–80.
Kriete A, Breithecker A, Rau WD. 3D imaging of lung tissue by confocal microscopy and micro-CT. Proc SPIE. 2001;4257:8.
Lin ASP, Barrows TH, Cartmell SH, Guldberg RE. Microarchitectural and mechanical characterization of oriented porous polymer scaffolds. Biomaterials. 2003;24(3):481–9.
Badea CT, Hedlund LW, Cook J, Berridge BR, Johnson GA. Micro-CT imaging assessment of dobutamine-induced cardiac stress in rats. J Pharmacol Toxicol Methods. 2011;63(1):24–9.
Badea CT, Johnston S, Johnson B, Lin M, Hedlund LW, Johnson GA. A dual micro-CT system for small animal imaging. Proc SPIE. 2008;6913:691342.
Kim AJ, et al. Micro-computed tomography provides high accuracy congenital heart disease diagnosis in neonatal and fetal mice. Circ Cardiovasc Imaging. 2013;6(4):551–9.
Sangaralingham SJ, et al. Cardiac micro-computed tomography imaging of the aging coronary vasculature. Circ Cardiovasc Imaging. 2012;5(4):518–24.
Makdisi G, Wang IW. Extra corporeal membrane oxygenation (ECMO) review of a lifesaving technology. J Thoracic Dis. 2015;7(7):E166–76.
Pekkan K, et al. In vitro validation of a self-driving aortic-turbine venous-assist device for Fontan patients. J Thoracic Cardiovas Surg. 2018;156(1):292–301.e7.
Thiex R, et al. Haemorrhagic tracheal necrosis as a lethal complication of an aneurysm model in rabbits via endoluminal incubation with elastase. Acta Neurochir. 2004;146(3):285–9.
Kim M-S, et al. Intravenous contrast media application using cone-beam computed tomography in a rabbit model. Imaging Sci Dent. 2015;45(1):31–9.
Miskolczi L, Nemes B, Cesar L, Masanari O, Gounis MJ. Contrast Injection via the central artery of the left ear in rabbits: a new technique to simplify follow-up studies. Am J Neuroradiol. 2005;26(8):1964.
Pannu HK, Thompson RE, Phelps J, Magee CA, Fishman EK. Optimal contrast agents for vascular imaging on computed tomography: iodixanol versus iohexol1. Acad Radiol. 2005;12(5):576–84.
Mortier P, et al. Comparison of drug-eluting stent cell size using micro-CT: Important data for bifurcation stent selection. EuroIntervention. 2008;4:391–6.
Muhammad J, et al. Patient-specific atrial hemodynamics of a double lumen neonatal cannula in correct caval position. Artif Organs. 2018;42(4):401–9.
Eom H-J, et al. Coronary bifurcation stent morphology in dual-source CT: validation with micro-CT. Int J Card Imaging. 2016;32(11):1659–65.
Vanommeslaeghe F, Van Biesen W, Dierick M, Boone M, Dhondt A, Eloot S. Micro-computed tomography for the quantification of blocked fibers in hemodialyzers. Sci Rep. 2018;8(1):2677.
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Çakmak, B., Ermek, E., Jamil, M., Horasan, A., Pekkan, K. (2020). Applications of Micro-CT in Cardiovascular Engineering and Bio-inspired Design. In: Orhan, K. (eds) Micro-computed Tomography (micro-CT) in Medicine and Engineering. Springer, Cham. https://doi.org/10.1007/978-3-030-16641-0_11
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DOI: https://doi.org/10.1007/978-3-030-16641-0_11
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