Abstract
The vascular system is a highly complex and well-organized system in which signal transduction plays critical physiological and pathophysiological roles. The vasculature is equipped with numerous receptors and complex intracellular signaling molecules and networks that drive appropriate responses to extracellular stimuli. Understanding mechanisms whereby extracellular stimuli modulate vascular cell function in health and disease will facilitate discovery and development of new disease-targeted therapies. To date most classical drugs exert effects by inhibiting cell membrane receptors. In this chapter we describe some of the major intracellular signaling systems in vascular smooth muscle cells (VSMCs) with particular emphasis on the role of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs).
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Vass M, Kooistra AJ, Yang D, Stevens RC, Wang MW, de Graaf C. Chemical diversity in the G protein-coupled receptor superfamily. Trends Pharmacol Sci. 2018;39(5):494–512.
Gurevich VV, Gurevich EV. Molecular mechanisms of GPCR signaling: a structural perspective. Int J Mol Sci. 2017;18(12).
Hilger D, Masureel M, Kobilka BK. Structure and dynamics of GPCR signaling complexes. Nat Struct Mol Biol. 2018;25(1):4–12.
Jong YI, Harmon SK, O’Malley KL. GPCR signalling from within the cell. Br J Pharmacol. 2017; https://doi.org/10.1111/bph.14023.
Latorraca NR, Venkatakrishnan AJ, Dror RO. GPCR dynamics: structures in motion. Chem Rev. 2017;117(1):139–55.
Touyz RM, Alves-Lopes R, Rios FJ, Camargo LL, Anagnostopoulou A, Arner A, Montezano AC. Vascular smooth muscle contraction in hypertension. Cardiovasc Res. 2018;114(4):529–39.
Pavlos NJ, Friedman PA. GPCR signaling and trafficking: the long and short of it. Trends Endocrinol Metab. 2017;28(3):213–26.
Strassheim D, Karoor V, Stenmark K, Verin A, Gerasimovskaya E. A current view of G protein-coupled receptor – mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention. Vessel Plus. 2018;2:29.
Thal DM, Vuckovic Z, Draper-Joyce CJ, Liang YL, Glukhova A, Christopoulos A, Sexton PM. Recent advances in the determination of G protein-coupled receptor structures. Curr Opin Struct Biol. 2018;51:28–34.
J Agata, Miao RQ, Yayama K, Chao L, Chao J. Bradykinin B(1) receptor mediates inhibition of neointima formation in rat artery after balloon angioplasty. Hypertension. 2000;36(3):364–70.
Todaka T, Yokoyama C, Yanamoto H, Hashimoto N, Nagata I, Tsukahara T, Hara S, Hatae T, Morishita R, Aoki M, Ogihara T, Kaneda Y, Tanabe T. Gene transfer of human prostacyclin synthase prevents neointimal formation after carotid balloon injury in rats. Stroke. 1999;30(2):419–26.
Chiasson-MacKenzie C, McClatchey AI. Cell-cell contact and receptor tyrosine kinase signaling. Cold Spring Harb Perspect Biol. 2018;10(6):a029215.
Critchley WR, Pellet-Many C, Ringham-Terry B, Harrison MA, Zachary IC, Ponnambalam S. Receptor tyrosine kinase ubiquitination and De-ubiquitination in signal transduction and receptor trafficking. Cell. 2018;7(3):22.
Simons M, Gordon E, Claesson-Welsh L. Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol. 2016;17:611–25.
Du Z, Lovly CM. Mechanisms of receptor tyrosine kinase activation in cancer. Mol Cancer. 2018;17(1):58.
Lai Y, Zhao Z, Zeng T, Liang X, Chen D, Duan X, Zeng G, Wu W. Crosstalk between VEGFR and other receptor tyrosine kinases for TKI therapy of metastatic renal cell carcinoma. Cancer Cell Int. 2018;18:31.
Montor WR, Salas AROSE, Melo FHM. Receptor tyrosine kinases and downstream pathways as druggable targets for cancer treatment: the current arsenal of inhibitors. Mol Cancer. 2018;17(1):55.
Small HY, Montezano AC, Rios FJ, Savoia C, Touyz RM. Hypertension due to antiangiogenic cancer therapy with vascular endothelial growth factor inhibitors: understanding and managing a new syndrome. Can J Cardiol. 2014;30:534–43.
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Neves, K.B., Touyz, R.M. (2019). Vascular Signaling. In: Touyz, R., Delles, C. (eds) Textbook of Vascular Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-16481-2_8
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DOI: https://doi.org/10.1007/978-3-030-16481-2_8
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