Abstract
This chapter will provide the reader with an overview of the contemporary management of coronary heart disease. It will touch on the epidemiology of the condition and highlight key points of its pathophysiology and risk factors. The diagnostic process and modalities employed will be discussed, and the various therapeutic options will be explained. Finally, the area of acute coronary syndromes will be reviewed and an outline of current best practice guidelines provided. While not an exhaustive review of the subject, we hope to provide an accessible analysis of the current evidence-based treatment of coronary heart disease to the non-specialist.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Global Health Estimates 2016: deaths by cause, age, sex, by country and by region, 2000–2016. Geneva: World Health Organization; 2018. Available from: www.who.int/healthinfo/global_burden_disease/estimates/en/.
Deaths registered in England and Wales (series DR): 2016: Office for National Statistics; 2017. Available from: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsregisteredinenglandandwalesseriesdr/2016.
Doll R, Peto R, Boreham J, Sutherland I. Mortality in relation to smoking: 50 years’ observations on male British doctors. Br Med J. 2004;328(7455):1519–28.
Hagg S, Fall T, Ploner A, Magi R, Fischer K, Draisma HHM, et al. Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. Int J Epidemiol. 2015;44(2):578–86.
Cole CB, Nikpay M, Stewart AFR, McPherson R. Increased genetic risk for obesity in premature coronary artery disease. Eur J Hum Genet. 2016;24(4):587–91.
Logue J, Murray HM, Welsh P, Shepherd J, Packard C, Macfarlane P, et al. Obesity is associated with fatal coronary heart disease independently of traditional risk factors and deprivation. Heart. 2011;97(7):564–8.
Jones PJH. Dietary cholesterol and the risk of cardiovascular disease in patients: a review of the Harvard Egg Study and other data. Int J Clin Pract. 2009;63(s163):1–8.. 37–43
Allonier C, Chevalier A, Zins M, Catelinois O, Consoli SM, Goldberg M, et al. Anxiety or depressive disorders and risk of ischaemic heart disease among French power company employees. Int J Epidemiol. 2004;33(4):779–86.
Hagstrom E, Norlund F, Stebbins A, Armstrong PW, Chiswell K, Granger CB, et al. Psychosocial stress and major cardiovascular events in patients with stable coronary heart disease. J Intern Med. 2018;283(1):83–92.
Kivimaki M, Nyberg ST, Batty GD, Fransson EI, Heikkila K, Alfredsson L, et al. Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet. 2012;380(9852):1491–7.
Li J, Zhang M, Loerbroks A, Angerer P, Siegrist J. Work stress and the risk of recurrent coronary heart disease events: a systematic review and meta-analysis. Int J Occup Med Environ Health. 2015;28(1):8–19.
Newton JN, Briggs ADM, Murray CJL, Dicker D, Foreman KJ, Wang H, et al. Changes in health in England, with analysis by English regions and areas of deprivation, 1990–2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2015;386(10010):2257–74.
Mackenbach JP, Cavelaars A, Kunst AE, Groenhof F, Inequ EUWGS. Socioeconomic inequalities in cardiovascular disease mortality – an international study. Eur Heart J. 2000;21(14):1141–51.
Carlsson AC, Li X, Holzmann MJ, Wandell P, Gasevic D, Sundquist J, et al. Neighbourhood socioeconomic status and coronary heart disease in individuals between 40 and 50 years. Heart. 2016;102(10):775–82.
Avendano M, Kunst AE, Huisman M, Lenthe FV, Bopp M, Regidor E, et al. Socioeconomic status and ischaemic heart disease mortality in 10 Western European populations during the 1990s. Heart. 2006;92(4):461–7.
Alonso Gonzalez M, Rodriguez Artalejo F, Del Rey Calero J. Relationship between socioeconomic status and ischaemic heart disease in cohort and case-control studies: 1960–1993. Int J Epidemiol. 1998;27(3):350–8.
Vyas MV, Garg AX, Iansavichus AV, Costella J, Donner A, Laugsand LE, et al. Shift work and vascular events: systematic review and meta-analysis. BMJ-Br Med J. 2012;345:e4800.
O’Donnell CJ, Nabel EG. Genomic medicine genomics of cardiovascular disease. N Engl J Med. 2011;365(22):2098–109.
Tonino PAL, De Bruyne B, Pijls NHJ, Siebert U, Ikeno F, van ’t Veer M, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360(3):213–24.
Roffi M, Patrono C, Collet J-P, Mueller C, Valgimigli M, Andreotti F, et al. 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016;37(3):267–+.
Pedersen TR, Kjekshus J, Berg K, Haghfelt T, Faergeman O, Thorgeirsson G, et al. Randomized trial of cholesterol-lowering in 4444 patients with coronary-heart-disease – the scandinavian simvastatin survival study (4S). Lancet. 1994;344(8934):1383–9.
DeWilde S, Carey IM, Richards N, Whincup PH, Cook DG. Trends in secondary prevention of ischaemic heart disease in the UK 1994–2005: use of individual and combination treatment. Heart. 2008;94(1):83–8.
Hippisley-Cox J, Coupland C. Effect of combinations of drugs on all cause mortality in patients with ischaemic heart disease: nested case-control analysis. Bmj-Br Med J. 2005;330(7499):1059–63.
Neumann F-J, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al. 2018 ESC/EACTS guidelines on myocardial revascularization. Eur Heart J. 2019;40(2):87–165.
Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119–+.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Collison, D., Oldroyd, K.G. (2019). Ischaemic Heart Disease. In: Touyz, R., Delles, C. (eds) Textbook of Vascular Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-16481-2_33
Download citation
DOI: https://doi.org/10.1007/978-3-030-16481-2_33
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-16480-5
Online ISBN: 978-3-030-16481-2
eBook Packages: MedicineMedicine (R0)