Abstract
Growing evidence indicates that cells are able to communicate with neighbouring and distant cells in the body by production of extracellular vesicles (EV). EV are classified according to their size and mechanisms of formation. Exosomes and microparticles are the most extensively studied clinically relevant forms of EV, and they often reflect the activation status of the parent cell, by carrying similar surface markers and cargo. Because of these molecular characteristics, EV are considered to be mediators of cell activation by transferring molecules (e.g., proteins, lipids, and nucleic acids) to neighbouring or distant cell populations. Increased levels of circulating EV have been observed in various diseases, including hypertension, atherosclerosis, kidney diseases, and cancer. In this chapter, we will address the formation of different EV and their importance in cell-cell communication, controlling basic cellular functions in homeostatic and pathologic conditions associated with cardiovascular diseases. In addition, we highlight their role as biomarkers and discuss the potential of EV as therapeutic tools.
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References
Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255–89.
Burger D, et al. Microparticles: biomarkers and beyond. Clin Sci (Lond). 2013;124(7):423–41.
Kowal J, Tkach M, Thery C. Biogenesis and secretion of exosomes. Curr Opin Cell Biol. 2014;29:116–25.
Xu R, et al. Extracellular vesicle isolation and characterization: toward clinical application. J Clin Invest. 2016;126(4):1152–62.
Roucourt B, et al. Heparanase activates the syndecan-syntenin-ALIX exosome pathway. Cell Res. 2015;25(4):412–28.
Maas SLN, Breakefield XO, Weaver AM. Extracellular vesicles: unique intercellular delivery vehicles. Trends Cell Biol. 2017;27(3):172–88.
Villarroya-Beltri C, et al. Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun. 2013;4:2980.
Chevillet JR, et al. Quantitative and stoichiometric analysis of the microRNA content of exosomes. Proc Natl Acad Sci U S A. 2014;111(41):14888–93.
Loyer X, et al. Microvesicles as cell-cell messengers in cardiovascular diseases. Circ Res. 2014;114(2):345–53.
de Jong OG, et al. Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes. J Extracell Vesicles. 2012;1
Xie Z, et al. Adipose-derived exosomes exert proatherogenic effects by regulating macrophage foam cell formation and polarization. J Am Heart Assoc. 2018;7(5):e007442.
Qin B, et al. MicroRNA-150 targets ELK1 and modulates the apoptosis induced by ox-LDL in endothelial cells. Mol Cell Biochem. 2017;429(1–2):45–58.
Nguyen MA, et al. Extracellular vesicles secreted by atherogenic macrophages transfer microRNA to inhibit cell migration. Arterioscler Thromb Vasc Biol. 2018;38(1):49–63.
Vinas JL, et al. Transfer of microRNA-486-5p from human endothelial colony forming cell-derived exosomes reduces ischemic kidney injury. Kidney Int. 2016;90(6):1238–50.
Gomes CPC, et al. The function and therapeutic potential of long non-coding RNAs in cardiovascular development and disease. Mol Ther Nucl Acids. 2017;8:494–507.
Shan K, et al. Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction. Cell Death Dis. 2016;7(6):e2248.
Sun Z, et al. Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment. Mol Cancer. 2018;17(1):82.
Madrigal-Matute J, et al. Thioredoxin-1/peroxiredoxin-1 as sensors of oxidative stress mediated by NADPH oxidase activity in atherosclerosis. Free Radic Biol Med. 2015;86:352–61.
Pironti G, et al. Circulating exosomes induced by cardiac pressure overload contain functional angiotensin II type 1 receptors. Circulation. 2015;131(24):2120–30.
Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A. 2004;101(36):13368–73.
Choi DS, et al. Proteomics of extracellular vesicles: exosomes and ectosomes. Mass Spectrom Rev. 2015;34(4):474–90.
Qi Y, et al. Activation of the endogenous renin-angiotensin-aldosterone system or aldosterone administration increases urinary exosomal sodium channel excretion. J Am Soc Nephrol. 2016;27(2):646–56.
Jella KK, et al. Exosomal GAPDH from proximal tubule cells regulate ENaC activity. PLoS One. 2016;11(11):e0165763.
Gracia T, et al. Urinary exosomes contain MicroRNAs capable of paracrine modulation of tubular transporters in kidney. Sci Rep. 2017;7:40601.
Burger D, et al. High glucose increases the formation and pro-oxidative activity of endothelial microparticles. Diabetologia. 2017;60(9):1791–800.
Ghosh A, et al. Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice. J Clin Invest. 2008;118(5):1934–43.
Montecalvo A, et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2012;119(3):756–66.
Burger D, et al. Microparticles induce cell cycle arrest through redox-sensitive processes in endothelial cells: implications in vascular senescence. J Am Heart Assoc. 2012;1(3):e001842.
Burger D, et al. Endothelial microparticle-derived reactive oxygen species: role in endothelial signaling and vascular function. Oxidative Med Cell Longev. 2016;2016:5047954.
Shimoda M, Khokha R. Metalloproteinases in extracellular vesicles. Biochim Biophys Acta. 2017;1864(11 Pt A):1989–2000.
Bourdonnay E, et al. Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling. J Exp Med. 2015;212(5):729–42.
Amabile N, et al. Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study. Eur Heart J. 2014;35(42):2972–9.
Amabile N, et al. Predictive value of circulating endothelial microparticles for cardiovascular mortality in end-stage renal failure: a pilot study. Nephrol Dial Transplant. 2012;27(5):1873–80.
Nomura S, et al. Effects of losartan and simvastatin on monocyte-derived microparticles in hypertensive patients with and without type 2 diabetes mellitus. Clin Appl Thromb Hemost. 2004;10(2):133–41.
Sommeijer DW, et al. Pravastatin reduces fibrinogen receptor gpIIIa on platelet-derived microparticles in patients with type 2 diabetes. J Thromb Haemost. 2005;3(6):1168–71.
Wu SY, et al. Fish-oil supplementation alters numbers of circulating endothelial progenitor cells and microparticles independently of eNOS genotype. Am J Clin Nutr. 2014;100(5):1232–43.
Cheng V, et al. Restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery is associated with reduction in microparticles. Surg Obes Relat Dis. 2013;9(2):207–12.
Rodrigues KF, et al. Circulating microparticles levels are increased in patients with diabetic kidney disease: a case-control research. Clin Chim Acta. 2018;479:48–55.
Wang B, et al. Circulating microparticles in patients after ischemic stroke: a systematic review and meta-analysis. Rev Neurosci. 2018;11. https://doi.org/10.1515/revneuro‐2017‐0105.
Agouni A, et al. Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome. Am J Pathol. 2008;173(4):1210–9.
Munkonda MN, et al. Podocyte-derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36. J Extracell Vesicles. 2018;7(1):1432206.
Vader P, et al. Extracellular vesicles for drug delivery. Adv Drug Deliv Rev. 2016;106(Pt A):148–56.
EL Andaloussi S, et al. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013;12(5):347–57.
Ohno S, Drummen GP, Kuroda M. Focus on extracellular vesicles: development of extracellular vesicle-based therapeutic systems. Int J Mol Sci. 2016;17(2):172.
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Rios, F.J., Touyz, R.M., Montezano, A.C., Burger, D. (2019). Microparticles and Exosomes in Cell-Cell Communication. In: Touyz, R., Delles, C. (eds) Textbook of Vascular Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-16481-2_15
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DOI: https://doi.org/10.1007/978-3-030-16481-2_15
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