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Infectious Diseases: Modelling, Immunity

  • Klaus Krickeberg
  • Pham Van Trong
  • Pham Thi My Hanh
Chapter
Part of the Statistics for Biology and Health book series (SBH)

Abstract

It has been observed for centuries that a patient who survives an episode of certain infectious diseases such as smallpox or measles becomes immune for life against a further infection. For smallpox, the idea therefore arose to infect persons artificially by a “mild” form of the disease. This practice seems to have originated very early in China where dried smallpox scabs were blown into the nose of an individual who then contracted a mild form of the disease and was immune upon recovery. Starting in the eighteenth century, a modified procedure named “variolation” was used in Europe. Here the dried scabs were injected under the skin.

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Klaus Krickeberg
    • 1
  • Pham Van Trong
    • 2
  • Pham Thi My Hanh
    • 2
  1. 1.Grosser Kamp 4BielefeldGermany
  2. 2.Faculty of Public HealthThai Binh Medical UniversityThai BinhVietnam

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