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Nutrigenomic Immunity

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Abstract

The present chapter would first provide evidences from single nucleotide polymorphism (SNP) studies which have established the interaction between polymorphisms within the genes related to immune and inflammatory responses (CRP, IL-1, TNFα, IL-6, LTA4, and SCD-1) and diet composition (vitamin D status, botanical formulation, fat intake, and fatty acid supplementation). SNP studies also show that the content of inflammatory markers (IL-6, CRP, and α2-microglobulin) would be influenced by the interaction between polymorphisms within metabolic pathways (GCKR, Fok-1, and FADS 1/2) and diet composition (fat intake, nutritional counseling, and vitamin D therapy). It is followed by a synthesis of results from human and animal studies that demonstrate differential expression of genes related to immune response and inflammatory processes in response to single (acute) or repeated daily (chronic) consumption of different dietary interventions (vegetables, fruits, and other plant-derived products, fish oils and meals, plant oils and meals, micronutrients, ethnic dietary patterns, calorie restriction, oral challenge tests, different protein sources, and nutritional stress). Altogether, such immune-related gene-diet interactions might affect anthropometric parameters, metabolic profile, and cardiovascular measurements and thereby alter individual susceptibility to metabolic (obesity, diabetes, and non-alcoholic fatty liver diseases), autoimmune (Crohn’s disease), and cardiovascular disorders (atherosclerosis).

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Authors and Affiliations

  1. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Amene Saghazadeh & Nima Rezaei

  2. MetaCognition Interest Group (MCIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Amene Saghazadeh

  3. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Amene Saghazadeh

  4. Department of Cellular and Molecular Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Maryam Mahmoudi

  5. Dietitians and Nutrition Experts Team (DiNET), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Maryam Mahmoudi

  6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

  7. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Nima Rezaei

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  1. Amene Saghazadeh
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  2. Maryam Mahmoudi
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Correspondence to Nima Rezaei .

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Editors and Affiliations

  1. Department Cellular and Molecular Nutrition, Tehran University of Medical Sciences and Dietitians and Nutrition Experts Team (DiNET), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Maryam Mahmoudi

  2. Research Center for Immunodeficiencies, Tehran University of Medical Sciences and Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Nima Rezaei

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Saghazadeh, A., Mahmoudi, M., Rezaei, N. (2019). Nutrigenomic Immunity. In: Mahmoudi, M., Rezaei, N. (eds) Nutrition and Immunity. Springer, Cham. https://doi.org/10.1007/978-3-030-16073-9_24

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