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Advancements of Mass Spectrometry in Biomedical Research pp 327–358Cite as

Mass Spectrometry in Advancement of Redox Precision Medicine

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1140))

Abstract

Redox (portmanteau of reduction-oxidation) reactions involve the transfer of electrons between chemical species in biological processes fundamental to life. It is of outmost importance that cells maintain a healthy redox state by balancing the action of oxidants and antioxidants; failure to do so leads to a multitude of diseases including cancer, diabetes, fibrosis, autoimmune diseases, and cardiovascular and neurodegenerative diseases. From the perspective of precision medicine, it is therefore beneficial to interrogate the redox phenotype of the individual—similar to the use of genomic sequencing—in order to design tailored strategies for disease prevention and treatment. This chapter provides an overview of redox metabolism and focuses on how mass spectrometry (MS) can be applied to advance our knowledge in redox biology and precision medicine.

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Abbreviations

4-HDTE:

4-hydroxydodecatrienal

4-HHE:

4-hydroxy-2-hexenal

4-HNE:

4-hydroxy-2-nonenal

4-HNDE:

4-hydroxynondienal

8-oxo-dA:

8-oxo-2′-deoxyadenosine

8-oxo-dG:

8-oxo-2′-deoxyguanosine

AA:

Arachidonic acid

AhpC:

Alkyl hydroperoxide reductase subunit C

ALA:

Alpha-linolenic acid

APCI:

Atmospheric-pressure chemical ionization

BQB:

Bromoacetonylquinolinium bromide

CAT:

Catalase

CID:

Collision-induced dissociation

COX:

Cyclooxygenase

CYP450:

Cytochrome p450

Cys:

Cysteine

CySS:

Cystine

DCP-NEt2C:

DCP-NEt2-Coumarin

DHA:

Docosahexaenoic acid

DTT:

Dithiothreitol

E+:

Ethidium

EET:

Epoxyeicosatrienoic acid

ELISA:

Enzyme-linked immunosorbent assay

EPA:

Eicosapentaenoic acid

ESI:

Electrospray ionization

FEM:

N-(2-ferroceneethyl)maleimide

FMEA:

Ferrocenecarboxylic acid (2-maleimidoyl)ethylamide

FOX:

Ferrous oxidation of xylenol assay

GC:

Gas chromatography

GPX:

Glutathione peroxidase

GR:

Glutathione reductase

GSH:

Glutathione

GSSG:

Oxidized glutathione

Hb:

Hemoglobin

HCD:

High-energy collision-induced dissociation

Hcy:

Homocysteine

HE:

Hydroethidine

HETE:

Hydroxyeicosatetraenoic acid

HILIC:

Hydrophilic interaction chromatography

HMDB:

The Human Metabolome Database

HODE:

Hydroxyoctadecadienoic acid

HPLC:

High-performance liquid chromatography

HUVEC:

Human umbilical vein endothelial cells

IAA:

Iodoacetic acid

IAM:

Iodoacetamide

ICAT:

Isotope-coded affinity tag

IP:

Ion pair

IPCF:

Isopropylchlroformate

iTRAQ:

Isobaric tags for relative and absolute quantitation

LA:

Linoleic acid

LC:

Liquid chromatography

LDL:

Low-density lipoprotein

LLE:

Liquid-liquid extraction

LOOH:

Lipid hydroperoxide

LOX:

Lipoxygenase

M1dG:

3-(2-Deoxy-β-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine

MALDI:

Matrix assisted laser desorption/ionization

mBB:

Monobromobimane

MDA:

Malondialdehyde

MDMS-SL:

Multi-dimensional MS-based shotgun lipidomics

Met:

Methionine

MMTS:

Methyl ethanethiosulfonate

MRM:

Multiple reaction monitoring

MS:

Mass spectrometry

MSTP:

4-(5-Methanesulfonyl-[1,2,3,4]tetrazol-1-yl)-phenol

NAD+:

Nicotinamide adenine dinucleotide

NADP+:

Nicotinamide adenine dinucleotide phosphate

NBenzM:

N-benzylmaleimide

NCycloM:

N-cyclohexylmaleimide

ND:

Not determined

NEM:

N-ethylmaleimide

PBMC:

Peripheral blood mononuclear cells

PC:

Phosphatidylcholine

PCA:

Perchloric acid

PE:

Phosphatidylethanolamine

Pro:

Proline

PRX:

Peroxiredoxin

PS:

Phosphatidylserine

PTGS:

Prostaglandin endoperoxide synthase

PUFA:

Polyunsaturated fatty acid

RNS:

Reactive nitrogen species

ROS:

Reactive oxygen species

RP:

Reversed-phase

SIM:

Selected ion monitoring

SOD:

Superoxide dismutase

SPE:

Solid-phase extraction

SSA:

5-Sulfosalicylic acid

TBA:

Thiobarbituric acid

TBARS:

Thiobarbituric acid reactive substance

TCA:

Trichloroacetic acid

TCEP:

Tris(2-carboxyethyl)phosphine hydrochloride

TLC:

Thin-layer chromatography

TMT:

Tandem mass tag

TOF:

Time-of-flight

TRX:

Thioredoxin

Tyr:

Tyrosine

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Acknowledgments

The authors of this review article are supported by the National Cancer Institute and National Institute of Environmental Health Sciences under award numbers R33 ES025645 (C.M.F., H.W., A.W.T), U01 CA215848 (C.M.F, X.C., A.W.T.), and P30 CA012197 Comprehensive Cancer Center of Wake Forest University NCI CCSG (C.M.F., J.L.).

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Author notes

  1. Xiaofei Chen, Jingyun Lee, and Hanzhi Wu contributed equally to this chapter.

Authors and Affiliations

  1. Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA

    Xiaofei Chen, Jingyun Lee, Hanzhi Wu, Allen W. Tsang & Cristina M. Furdui

  2. Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA

    Jingyun Lee, Allen W. Tsang & Cristina M. Furdui

  3. Center for Redox Biology and Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA

    Allen W. Tsang & Cristina M. Furdui

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Correspondence to Cristina M. Furdui .

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  1. Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA

    Alisa G. Woods

  2. Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA

    Costel C. Darie

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Chen, X., Lee, J., Wu, H., Tsang, A.W., Furdui, C.M. (2019). Mass Spectrometry in Advancement of Redox Precision Medicine. In: Woods, A., Darie, C. (eds) Advancements of Mass Spectrometry in Biomedical Research. Advances in Experimental Medicine and Biology, vol 1140. Springer, Cham. https://doi.org/10.1007/978-3-030-15950-4_19

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