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Urological and Sexual Outcomes in Patients with Hirschsprung’s Disease

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Hirschsprung's Disease and Allied Disorders

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Abstract

Recent years have witnessed increasing interest toward the urological and sexual outcomes of Hirschsprung’s disease, as these are also major contributors to individual long-term well-being, physical health, and psychosocial functioning. Although the reported rates of iatrogenic injuries to the urogenital tract from pull-through surgery have been low, recent studies have suggested that the incidence of these and congenital urogenital anomalies may have been underestimated. As the developments of the enteric nervous system and renal tract share common genetic signaling pathways with an implied role for RET, the genetic basis of congenital anomalies of the kidney and urinary tract in association with Hirschsprung’s disease are of scientific interest. The data on postoperative physical sexual functions and fertility among Hirschsprung’s patients is limited, although physical sexual functions appear to be preserved in the majority. There is good evidence to suggest that domains of psychosexual functioning may be impaired by the presence of impairment of fecal control and chronic disease and that sensitive discussion of issues relating to sexuality could serve to alleviate distress and negative self-perceptions, with secondary benefits of improved social integration and disease-specific quality of life.

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Abbreviations

CAKUT:

Congenital anomalies of the kidney and urinary tract

FMTC:

Familial medullary thyroid cancer

GDNF:

Glial cell line neurotrophic factor

GFRα1:

GDNF family receptor alpha-1

LUTS:

Lower urinary tract symptoms

MEN2:

Multiple endocrine neoplasia type s2

QoL:

Quality of life

RET:

REarranged during Transfection

UI:

Urinary incontinence

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Authors and Affiliations

  1. Section of Pediatric Surgery, Pediatric Liver and Gut Research Group, Pediatric Research Center, Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

    Kristiina Kyrklund & Mikko P. Pakarinen

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  1. Kristiina Kyrklund
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  2. Mikko P. Pakarinen
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Correspondence to Mikko P. Pakarinen .

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  1. National Children’s Research Centre, Our Lady’s Childrens Hospital, University College Dublin, Dublin, Ireland

    Prem Puri

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Kyrklund, K., Pakarinen, M.P. (2019). Urological and Sexual Outcomes in Patients with Hirschsprung’s Disease. In: Puri, P. (eds) Hirschsprung's Disease and Allied Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-15647-3_31

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  • DOI: https://doi.org/10.1007/978-3-030-15647-3_31

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