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Drugs-Induced Injury, Infections, Vascular, Congenital, and Miscellaneous Disorders

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Surgical Pathology of Non-neoplastic Gastrointestinal Diseases
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Abstract

A variety of infections and drug reactions can involve the stomach. The clinical and pathological features of this heterogeneous group of entities are discussed. This chapter also discusses and illustrates vascular gastropathies, congenital disorders, polypoid lesions, and other conditions such as pancreatic acinar metaplasia, gastritis cystica polyposa/profunda, mucosal calcinosis, amyloidosis, and gastric siderosis.

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References

  1. Douthwaite AH, Lintott GAM. Gastroscopic observation of the effect of aspirin and certain other substances of the stomach. Lancet. 1938;232(6013):1225. https://doi.org/10.1016/S0140–6736(00)78970–7.

    Article  Google Scholar 

  2. Banner W Jr, Tong TG. Iron poisoning. Pediatr Clin N Am. 1986;33(2):393–409.

    Article  Google Scholar 

  3. McGuigan MA. Acute iron poisoning. Pediatr Ann. 1996;25(1):33–8.

    Article  CAS  PubMed  Google Scholar 

  4. Eckstein RP, Symons P. Iron tablets cause histopathologically distinctive lesions in mucosal biopsies of the stomach and esophagus. Pathology. 1996;28(2):142–5.

    Article  CAS  PubMed  Google Scholar 

  5. Abraham SC, Yardley JH, Wu TT. Erosive injury to the upper gastrointestinal tract in patients receiving iron medication: an underrecognized entity. Am J Surg Pathol. 1999;23(10):1241–7.

    Article  CAS  PubMed  Google Scholar 

  6. Smith IM, Bryson G, Glen P. Iron-induced gastric ulceration with radiological and endoscopic appearance of carcinoma. BMJ Case Reports. 2015;2015 https://doi.org/10.1136/bcr-2015–211997.

  7. Jalving M, Koornstra JJ, Wesseling J, Boezen HM, De Jong S, Kleibeuker JH. Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy. Aliment Pharmacol Ther. 2006;24(9):1341–8. https://doi.org/10.1111/j.1365–2036.2006.03127.x.

    Article  CAS  PubMed  Google Scholar 

  8. Ally MR, Veerappan GR, Maydonovitch CL, Duncan TJ, Perry JL, Osgard EM, et al. Chronic proton pump inhibitor therapy associated with increased development of fundic gland polyps. Dig Dis Sci. 2009;54(12):2617–22. https://doi.org/10.1007/s10620–009–0993-z.

    Article  CAS  PubMed  Google Scholar 

  9. Zelter A, Fernández JL, Bilder C, Rodríguez P, Wonaga A, Dorado F, et al. Fundic gland polyps and association with proton pump inhibitor intake: a prospective study in 1,780 endoscopies. Dig Dis Sci. 2011;56(6):1743–8. https://doi.org/10.1007/s10620–010–1493-x.

    Article  CAS  PubMed  Google Scholar 

  10. Choudhry U, Boyce HW Jr, Coppola D. Proton pump inhibitor-associated gastric polyps: a retrospective analysis of their frequency, and endoscopic, histologic, and ultrastructural characteristics. Am J Clin Pathol. 1998;110(5):615–21.

    Article  CAS  PubMed  Google Scholar 

  11. Declich P, Ambrosiani L, Bellone S, Tavani E, Prada A, Bortoli A, et al. Fundic gland polyps under omeprazole treatment [1] (multiple letters). Am J Clin Pathol. 1999;112(4):576–7.

    Article  CAS  PubMed  Google Scholar 

  12. Declich P, Tavani E, Porcellati M, Bellone S, Grassini R. Long-term omeprazole treatment and fundic gland polyps: a very authoritative proof against a link? [7]. Am J Gastroenterol. 2001;96(5):1650.

    Article  CAS  PubMed  Google Scholar 

  13. Berstad AE, Hatlebakk JG, Maartmann-Moe H, Berstad A, Brandtzaeg P. Helicobacter pylori gastritis and epithelial cell proliferation in patients with reflux oesophagitis after treatment with lansoprazole. Gut. 1997;41(6):740–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Klinkenberg-Knol EC, Festen HPM, Jansen JBMJ, Lamers CBHW, Nelis F, Snel P, et al. Long-term treatment with omeprazole for refractory reflux esophagitis: efficacy and safety. Ann Intern Med. 1994;121(3):161–7.

    Article  CAS  PubMed  Google Scholar 

  15. McCloy RF, Arnold R, Bardhan KD, Cattan D, Klinkenberg-Knol E, Maton PN, et al. Pathophysiological effects of long-term acid suppression in man. Dig Dis Sci. 1995;40(2 Supplement):96S–120S. https://doi.org/10.1007/BF02214874.

    Article  CAS  PubMed  Google Scholar 

  16. Lamberts R, Creutzfeldt W, Strüber HG, Brunner G, Solcia E. Long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth, and gastritis. Gastroenterology. 1993;104(5):1356–70.

    Article  CAS  PubMed  Google Scholar 

  17. Lamberts R, Brunner G, Solcia E. Effects of very long (up to 10 years) proton pump blockade on human gastric mucosa. Digestion. 2001;64(4):205–13. https://doi.org/10.1159/000048863.

    Article  CAS  PubMed  Google Scholar 

  18. Kuipers EJ, Lundell L, Klinkenberg-Knol EC, Havu N, Festen HPM, Liedman B, et al. Atrophic gastritis and helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N Engl J Med. 1996;334(16):1018–22. https://doi.org/10.1056/NEJM199604183341603.

    Article  CAS  PubMed  Google Scholar 

  19. Kuipers EJ, Uyterlinde AM, Pena AS, Hazenberg HJA, Bloemena E, Lindeman J, et al. Increase of helicobacter pylori-associated corpus gastritis during acid suppressive therapy: implications for long-term safety. Am J Gastroenterol. 1995;90(9):1401–6.

    CAS  PubMed  Google Scholar 

  20. Meining A, Kiel G, Stolte M. Changes in helicobacter pylori-induced gastritis in the antrum and corpus during and after 12 months of treatment with ranitidine and lansoprazole in patients with duodenal ulcer disease. Aliment Pharmacol Ther. 1998;12(8):735–40. https://doi.org/10.1046/j.1365–2036.1998.00370.x.

    Article  CAS  PubMed  Google Scholar 

  21. Kuipers EJ, Lee A, Klinkenberg-Knol EC, Meuwissen SGM. The development of atrophic gastritis—helicobacter pylori and the effects of acid suppressive therapy. Aliment Pharmacol Ther. 1995;9(4):331–40. https://doi.org/10.1111/j.1365–2036.1995.tb00391.x.

    Article  CAS  PubMed  Google Scholar 

  22. Matsukuma K, Gui D, Olson KA, Tejaswi S, Clayton EF, Thai A. OsmoPrep-associated gastritis. Am J Surg Pathol. 2016;40(11):1550–6. https://doi.org/10.1097/PAS.0000000000000706.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Parfitt JR, Jayakumar S, Driman DK. Mycophenolate Mofetil-related gastrointestinal mucosal injury: variable injury patterns, including graft-versus-host disease-like changes. Am J Surg Pathol. 2008;32(9):1367–72. https://doi.org/10.1097/PAS.0b013e31816bf3fe.

    Article  PubMed  Google Scholar 

  24. Nguyen T, Park JY, Scudiere JR, Montgomery E. Mycophenolic acid (cellcept and myofortic) induced injury of the upper gi tract. Am J Surg Pathol. 2009;33(9):1355–63. https://doi.org/10.1097/PAS.0b013e3181a755bd.

    Article  PubMed  Google Scholar 

  25. Iacobuzio-Donahue CA, Lee EL, Abraham SC, Yardley JH, Wu TT. Colchicine toxicity: distinct morphologic findings in gastrointestinal biopsies. Am J Surg Pathol. 2001;25(8):1067–73. https://doi.org/10.1097/00000478–200108000–00012.

    Article  CAS  PubMed  Google Scholar 

  26. Al-Daraji WI, Al-Mahmoud RM, Ilyas M. Gastric changes following colchicine therapy in patients with FMF. Dig Dis Sci. 2008;53(8):2079–82. https://doi.org/10.1007/s10620–007–0132–7.

    Article  CAS  PubMed  Google Scholar 

  27. Torbenson M, Montgomery EA, Iacobuzio-Donahue C, Yardley JH, Wu TT, Abraham SC. Colchicine effect in a colonic hyperplastic polyp: a lesion mimicking serrated adenoma. Arch Pathol Lab Med. 2002;126(5):615–7.

    PubMed  Google Scholar 

  28. Daniels JA, Gibson MK, Xu L, Sun S, Canto MI, Heath E, et al. Gastrointestinal tract epithelial changes associated with taxanes: marker of drug toxicity versus effect. Am J Surg Pathol. 2008;32(3):473–7. https://doi.org/10.1097/PAS.0b013e3181582331.

    Article  PubMed  Google Scholar 

  29. Jonassaint NL, Guo N, Califano JA, Montgomery EA, Armanios M. The gastrointestinal manifestations of telomere-mediated disease. Aging Cell. 2013;12(2):319–23. https://doi.org/10.1111/acel.12041.

    Article  CAS  PubMed  Google Scholar 

  30. Taha AS. Histopathological aspects of mucosal injury related to non-steroidal anti-inflammatory drugs. Ital J Gastroenterol. 1996;28(SUPPL. 4):12–5.

    CAS  PubMed  Google Scholar 

  31. Quinn CM, Bjarnason I, Price AB. Gastritis in patients on non-steroidal anti-inflammatory drugs. Histopathology. 1993;23(4):341–8. https://doi.org/10.1111/j.1365–2559.1993.tb01217.x.

    Article  CAS  PubMed  Google Scholar 

  32. Hirschowitz BI, Lanas A. Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse. J Clin Gastroenterol. 2002;34(5):523–8. https://doi.org/10.1097/00004836–200205000–00008.

    Article  PubMed  Google Scholar 

  33. Sung JJY, Russell RI, Yeomans N, Chan FKL, Chen SL, Fock KM, et al. Non-steroidal anti-inflammatory drug toxicity in the upper gastrointestinal tract. J Gastroenterol Hepatol. 2000;15(SUPPL. OCTOBER):G58–68. https://doi.org/10.1046/j.1440–1746.2000.02267.x.

    Article  CAS  PubMed  Google Scholar 

  34. Jewell LD, Fields AL, Murray CJW, Thomson ABR. Erosive gastroduodenitis with marked epithelial atypia after hepatic arterial infusion chemotherapy. Am J Gastroenterol. 1985;80(6):421–4. https://doi.org/10.1111/j.1572–0241.1985.tb02136.x.

    Article  CAS  PubMed  Google Scholar 

  35. Wells JJ, Nostrant TT, Wilson JAP, Gyves JW. Gastroduodenal ulcerations in patients receiving selective hepatic artery infusion chemotherapy. Am J Gastroenterol. 1985;80(6):425–9. https://doi.org/10.1111/j.1572–0241.1985.tb02137.x.

    Article  CAS  PubMed  Google Scholar 

  36. Weidner N, Smith JG, LaVanway JM. Peptic ulceration with marked epithelial atypia following hepatic arterial infusion chemotherapy. A lesion initially misinterpreted as carcinoma. Am J Surg Pathol. 1983;7(3):261–8.

    Article  CAS  PubMed  Google Scholar 

  37. Petras RE, Hart WR, Bukowski RM. Gastric epithelial atypia associated with hepatic arterial infusion chemotherapy. Its distinction from early gastric carcinoma. Cancer. 1985;56(4):745–50. https://doi.org/10.1002/1097–0142(19850815)56:4<745::AID-CNCR2820560408>3.0.CO;2-Q.

    Article  CAS  PubMed  Google Scholar 

  38. Brien TP, Farraye FA, Odze RD. Gastric dysplasia-like epithelial atypia associated with chemoradiotherapy for esophageal cancer: a clinicopathologic and immunohistochemical study of 15 cases. Mod Pathol. 2001;14(5):389–96. https://doi.org/10.1038/modpathol.3880323.

    Article  CAS  PubMed  Google Scholar 

  39. Lim LC, Gibbs P, Yip D, Shapiro JD, Dowling R, Smith D, et al. A prospective evaluation of treatment with selective internal radiation therapy (SIR-spheres) in patients with unresectable liver metastases from colorectal cancer previously treated with 5-FU based chemotherapy. BMC Cancer. 2005;5 https://doi.org/10.1186/1471–2407–5-132.

  40. Ogawa F, Mino-Kenudson M, Shimizu M, Ligato S, Lauwers GY. Gastroduodenitis associated with yttrium 90-microsphere selective internal radiation: an iatrogenic complication in need of recognition. Arch Pathol Lab Med. 2008;132(11):1734–8. https://doi.org/10.1043/1543-2165-132.11.1734.

    Article  PubMed  Google Scholar 

  41. Crowder CD, Grabowski C, Inampudi S, Sielaff T, Sherman CA, Batts KP. Selective internal radiation therapy-induced extrahepatic injury an emerging cause of iatrogenic organ damage. Am J Surg Pathol. 2009;33(7):963–75. https://doi.org/10.1097/PAS.0b013e31817ed787.

    Article  PubMed  Google Scholar 

  42. Abraham SC, Bhagavan BS, Lee LA, Rashid A, Wu TT. Upper gastrointestinal tract injury in patients receiving Kayexalate (sodium polystyrene sulfonate) in sorbitol: clinical, endoscopic, and histopathologic findings. Am J Surg Pathol. 2001;25(5):637–44. https://doi.org/10.1097/00000478–200105000–00011.

    Article  CAS  PubMed  Google Scholar 

  43. Harel Z, Harel S, Shah PS, Wald R, Perl J, Bell CM. Gastrointestinal adverse events with sodium polystyrene sulfonate (Kayexalate) use: a systematic review. Am J Med. 2013;126(3):264 .e9–e.e24. https://doi.org/10.1016/j.amjmed.2012.08.016.

    Article  CAS  PubMed  Google Scholar 

  44. Rashid A, Hamilton SR. Necrosis of the gastrointestinal tract in uremic patients as a result of sodium polystyrene sulfonate (kayexalate) in sorbitol: an underrecognized condition. Am J Surg Pathol. 1997;21(1):60–9. https://doi.org/10.1097/00000478–199701000–00007.

    Article  CAS  PubMed  Google Scholar 

  45. Roy-Chaudhury P, Meisels IS, Freedman S, Steinman TI, Steer M. Combined gastric and ileocecal toxicity (serpiginous ulcers) after oral Kayexalate in sorbital therapy. Am J Kidney Dis. 1997;30(1):120–2. https://doi.org/10.1016/S0272–6386(97)90574–6.

    Article  CAS  PubMed  Google Scholar 

  46. Chen Z, Scudiere JR, Montgomery E. Medication-induced upper gastrointestinal tract injury. J Clin Pathol. 2009;62(2):113–9. https://doi.org/10.1136/jcp.2008.058263.

    Article  CAS  PubMed  Google Scholar 

  47. Swanson BJ, Limketkai BN, Liu TC, Montgomery E, Nazari K, Park JY, et al. Sevelamer crystals in the gastrointestinal tract (GIT): a new entity associated with mucosal injury. Am J Surg Pathol. 2013;37(11):1686–93. https://doi.org/10.1097/PAS.0b013e3182999d8d.

    Article  PubMed  Google Scholar 

  48. Arnold MA, Swanson BJ, Crowder CD, Frankel WL, Lam-Himlin D, Singhi AD, et al. Colesevelam and colestipol: novel medication resins in the gastrointestinal tract. Am J Surg Pathol. 2014;38(11):1530–7. https://doi.org/10.1097/PAS.0000000000000260.

    Article  PubMed  Google Scholar 

  49. Vieth M, Montgomery E. Medication-associated gastrointestinal tract injury. Virchows Arch. 2017;470(3):245–66. https://doi.org/10.1007/s00428–017–2077–3.

    Article  CAS  PubMed  Google Scholar 

  50. Seminerio J, McGrath K, Arnold CA, Voltaggio L, Singhi AD. Medication-associated lesions of the GI tract. Gastrointest Endosc. 2014;79(1):140–50. https://doi.org/10.1016/j.gie.2013.08.027.

    Article  PubMed  Google Scholar 

  51. Goto K, Ogawa K. Lanthanum deposition is frequently observed in the gastric mucosa of dialysis patients with lanthanum carbonate therapy: a clinicopathologic study of 13 cases, including 1 case of lanthanum granuloma in the colon and 2 nongranulomatous gastric cases. Int J Surg Pathol. 2016;24(1):89–92. https://doi.org/10.1177/1066896915613434.

    Article  CAS  PubMed  Google Scholar 

  52. Rothenberg ME, Araya H, Longacre TA, Pasricha PJ. Lanthanum-induced gastrointestinal histiocytosis. ACG Case Rep J. 2015;2:187–9.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Yasunaga C, Haratake J, Ohtani A. Specific accumulation of lanthanum carbonate in the gastric mucosal histiocytes in a dialysis patient. Ther Apher Dial. 2015;19(6):622–4. https://doi.org/10.1111/1744–9987.12325.

    Article  PubMed  Google Scholar 

  54. Yabuki K, Shiba E, Harada H, Uchihashi K, Matsuyama A, Haratake J, et al. Lanthanum deposition in the gastrointestinal mucosa and regional lymph nodes in dialysis patients: analysis of surgically excised specimens and review of the literature. Pathol Res Pract. 2016;212(10):919–26. https://doi.org/10.1016/j.prp.2016.07.017.

    Article  PubMed  Google Scholar 

  55. Hoda RS, Sanyal S, Abraham JL, Everett JM, Hundemer GL, Yee E, et al. Lanthanum deposition from oral lanthanum carbonate in the upper gastrointestinal tract. Histopathology. 2017;70(7):1072–8. https://doi.org/10.1111/his.13178.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Davis RL, Abraham JL. Lanthanum deposition in a dialysis patient. Nephrol Dial Transplant. 2009;24(10):3247–50. https://doi.org/10.1093/ndt/gfp364.

    Article  PubMed  Google Scholar 

  57. Rubio-Tapia A, Herman ML, Ludvigsson JF, Kelly DG, Mangan TF, Wu TT, et al. Severe spruelike enteropathy associated with olmesartan. Mayo Clin Proc. 2012;87(8):732–8. https://doi.org/10.1016/j.mayocp.2012.06.003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Shih AR, Lauwers GY, Mattia A, Schaefer EA, Misdraji J. Vascular injury characterizes doxycycline-induced upper gastrointestinal tract mucosal injury. Am J Surg Pathol. 2017;41(3):374–81. https://doi.org/10.1097/PAS.0000000000000792.

    Article  PubMed  Google Scholar 

  59. Xiao SY, Zhao L, Hart J, Semrad CE. Doxycycline-induced gastric and esophageal mucosal injuries with vascular degeneration. Am J Surg Pathol. 2013;37(7):1115–6. https://doi.org/10.1097/PAS.0b013e31828f5b3a.

    Article  PubMed  Google Scholar 

  60. Shaddy SM, Arnold MA, Shilo K, Frankel WL, Harzman AE, Stanich PP, et al. Crospovidone and microcrystalline cellulose. Am J Surg Pathol. 2017;41(4):564–9. https://doi.org/10.1097/PAS.0000000000000790.

    Article  PubMed  Google Scholar 

  61. Rada-Palomino A, Muñoz-Duyos A, Pérez-Romero N, Vargas-Pierola H, Puértolas-Rico N, Ruiz-Campos L, et al. Phlegmonous gastritis: a rare entity as a differential diagnostic of an acute abdomen. Description of a case and a bibliographic review. Revista Espanola de Enfermedades Digestivas. 2014;106(6):418–24.

    PubMed  Google Scholar 

  62. Kim GY, Ward J, Henessey B, Peji J, Godell C, Desta H, et al. Phlegmonous gastritis: case report and review. Gastrointest Endosc. 2005;61(1):168–74. https://doi.org/10.1016/S0016–5107(04)02217–5.

    Article  PubMed  Google Scholar 

  63. Guo J, Young SK, Lorenzo CR, Lee CM, Kanel GC, Brynes RK, et al. Phlegmonous gastritis in a patient with myeloid sarcoma: a case report. Appl Immunohistochem Mol Morphol. 2009;17(5):458–62. https://doi.org/10.1097/PAI.0b013e31819f86e2.

    Article  PubMed  Google Scholar 

  64. Al Rasheed MR, Senseng CG. Sarcina ventriculi : review of the literature. Arch Pathol Lab Med. 2016;140(12):1441–5. https://doi.org/10.5858/arpa.2016–0028-RS.

    Article  PubMed  Google Scholar 

  65. Laass MW, Pargac N, Fischer R, Bernhardt H, Knoke M, Henker J. Emphysematous gastritis caused by Sarcina ventriculi. Gastrointest Endosc. 2010;72(5):1101–3. https://doi.org/10.1016/j.gie.2010.02.021.

    Article  PubMed  Google Scholar 

  66. Tolentino LF, Kallichanda N, Javier B, Yoshimori R, French SW. A case report of gastric perforation and peritonitis associated with opportunistic infection by Sarcina ventriculi. Lab Med. 2003;34(7):535–7. https://doi.org/10.1309/CDFF-04HE-9FHD-QPAN.

    Article  Google Scholar 

  67. Haroon Al Rasheed MR, Kim GJ, Senseng C. A rare case of Sarcina ventriculi of the stomach in an asymptomatic patient. Int J Surg Pathol. 2016;24(2):142–5.

    Article  PubMed  Google Scholar 

  68. Lam-Himlin D, Tsiatis AC, Montgomery E, Pai RK, Brown JA, Razavi M, et al. Sarcina organisms in the gastrointestinal tract: a clinicopathologic and molecular study. Am J Surg Pathol. 2011;35(11):1700–5. https://doi.org/10.1097/PAS.0b013e31822911e6.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Crowther JS. Sarcina ventriculi in human faeces. J Med Microbiol. 1971;4(3):343–50.

    Article  CAS  PubMed  Google Scholar 

  70. Lowe SE, Pankratz HS, Zeikus JG. Influence of pH extremes on sporulation and ultrastructure of Sarcina ventriculi. J Bacteriol. 1989;171(7):3775–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Canale-Parola E. Biology of the sugar-fermenting Sarcinae. Bacteriol Rev. 1970;34(1):82–97.

    CAS  PubMed  PubMed Central  Google Scholar 

  72. Mylona EE, Baraboutis IG, Papastamopoulos V, Tsagalou EP, Vryonis E, Samarkos M, et al. Gastric syphilis: a systematic review of published cases of the last 50 years. Sex Transm Dis. 2010;37(3):177–83. https://doi.org/10.1097/OLQ.0b013e3181c0d51f.

    Article  PubMed  Google Scholar 

  73. Martín-Ezquerra G, Fernandez-Casado A, Barco D, Jucglà A, Juanpere-Rodero N, Manresa JM, et al. Treponema pallidum distribution patterns in mucocutaneous lesions of primary and secondary syphilis: an immunohistochemical and ultrastructural study. Hum Pathol. 2009;40(5):624–30. https://doi.org/10.1016/j.humpath.2008.10.017.

    Article  CAS  PubMed  Google Scholar 

  74. Chen CY, Chi KH, George RW, Cox DL, Srivastava A, Rui Silva M, et al. Diagnosis of gastric syphilis by direct immunofluorescence staining and real-time PCR testing. J Clin Microbiol. 2006;44(9):3452–6. https://doi.org/10.1128/JCM.00721–06.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. Neafie RC, Marty AM. Unusual infections in humans. Clin Microbiol Rev. 1993;6(1):34–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Rank EL, Goldenberg SA, Hasson J, Cartun RW, Grey N. Treponema pallidum and helicobacter pylori recovered in a case of chronic active gastritis. Am J Clin Pathol. 1992;97(1):116–20.

    Article  CAS  PubMed  Google Scholar 

  77. Fernandez-Flores A, Garcia Varona A. Anti-Treponema antibody also stains helicobacter heilmannii. Appl Immunohistochem Mol Morphol. 2016;24(3):e20–1. https://doi.org/10.1097/PAI.0000000000000266.

    Article  PubMed  Google Scholar 

  78. Hinnant KL, Rotterdam HZ, Bell ET, Tapper ML. Cytomegalovirus infection of the alimentary tract: a clinicopathological correlation. Am J Gastroenterol. 1986;81(10):944–50.

    CAS  PubMed  Google Scholar 

  79. Xiao SY, Hart J. Marked gastric foveolar hyperplasia associated with active cytomegalovirus infection. Am J Gastroenterol. 2001;96(1):223–6. https://doi.org/10.1111/j.1572–0241.2001.03480.x.

    Article  CAS  PubMed  Google Scholar 

  80. Nohr EW, Itani DM, Andrews CN, Kelly MM. Varicella-zoster virus gastritis: case report and review of the literature. Int J Surg Pathol. 2017;25(5):449–52. https://doi.org/10.1177/1066896917696751.

    Article  PubMed  Google Scholar 

  81. Rivera-Vaquerizo PA, Gomez-Garrido J, Vicente-Gutierrez M, Blasco-Colmenarejo M, Mayor-Lopez J, Perez-Flores R. Varicella zoster gastritis 3 years after bone marrow transplantation for treatment of acute leukemia. Gastrointest Endosc. 2001;53(7):809–10.

    Article  CAS  PubMed  Google Scholar 

  82. Chen ZM, Shah R, Zuckerman GR, Wang HL. Epstein-Barr virus gastritis: an underrecognized form of severe gastritis simulating gastric lymphoma. Am J Surg Pathol. 2007;31(9):1446–51. https://doi.org/10.1097/PAS.0b013e318050072f.

    Article  PubMed  Google Scholar 

  83. Kitayama Y, Honda S, Sugimura H. Epstein-Barr virus-related gastric pseudolymphoma in infectious mononucleosis. Gastrointest Endosc. 2000;52(2):290–1. https://doi.org/10.1067/mge.2000.107715.

    Article  CAS  PubMed  Google Scholar 

  84. Loffeld RJ, Loffeld BC, Arends JW, Flendrig JA, van Spreeuwel JP. Fungal colonization of gastric ulcers. Am J Gastroenterol. 1988;83(7):730–3.

    CAS  PubMed  Google Scholar 

  85. Cherney CL, Chutuape A, Fikrig MK. Fatal invasive gastric mucormycosis occurring with emphysematous gastritis: case report and literature review. Am J Gastroenterol. 1999;94(1):252–6. https://doi.org/10.1111/j.1572–0241.1999.00809.x.

    Article  CAS  PubMed  Google Scholar 

  86. Mohamed AE, Ghandour ZM, Al-Karawi MA, Yasawy MI, Sammak B. Gastrointestinal parasites presentations and histological diagnosis from endoscopic biopsies and surgical specimens. Saudi Med J. 2000;21(7):629–34.

    CAS  PubMed  Google Scholar 

  87. Forester G, Sidhom O, Nahass R, Andavolu R. AIDS-associated cryptosporidiosis with gastric stricture and a therapeutic response to paromomycin. Am J Gastroenterol. 1994;89(7):1096–8.

    CAS  PubMed  Google Scholar 

  88. Garone MA, Winston BJ, Lewis JH. Cryptosporidiosis of the stomach. Am J Gastroenterol. 1986;81(6):465–70.

    CAS  PubMed  Google Scholar 

  89. Sohn WM, Na BK, Kim TH, Park TJ. Anisakiasis: report of 15 gastric cases caused by Anisakis type I larvae and a brief review of Korean Anisakiasis cases. Korean J Parasitol. 2015;53(4):465–70. https://doi.org/10.3347/kjp.2015.53.4.465.

    Article  PubMed  PubMed Central  Google Scholar 

  90. Rider JA, Klotz AP, Kirsner JB. Gastritis with veno-capillary ectasia as a source of massive gastric hemorrhage. Gastroenterology. 1953;24(1):118–23. https://doi.org/10.1016/S0016–5085(53)80070–3.

    Article  CAS  PubMed  Google Scholar 

  91. Jabbari M, Cherry R, Lough JO, Daly DS, Kinnear DG, Goresky CA. Gastric antral vascular ectasia: the watermelon stomach. Gastroenterology. 1984;87(5):1165–70. https://doi.org/10.1016/S0016–5085(84)80080–3.

    Article  CAS  PubMed  Google Scholar 

  92. Dulai GS, Jensen DM, Kovacs TOG, Gralnek IM, Jutabha R. Endoscopic treatment outcomes in watermelon stomach patients with and without portal hypertension. Endoscopy. 2004;36(1):68–72. https://doi.org/10.1055/s-2004–814112.

    Article  CAS  PubMed  Google Scholar 

  93. Charneau J, Petit R, Cales P, Dauver A, Boyer J. Antral motility in patients with cirrhosis with or without gastric antral vascular ectasia. Gut. 1995;37(4):488–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Quintero E, Pique JM, Bombi JA, Bordas JM, Sentis J, Elena M, et al. Gastric mucosal vascular ectasias causing bleeding in cirrhosis. A distinct entity associated with hypergastrinemia and low serum levels of pepsinogen I. Gastroenterology. 1987;93(5):1054–61.

    Article  CAS  PubMed  Google Scholar 

  95. Gostout CJ, Viggiano TR, Ahlquist DA, Wang KK, Larson MV, Balm R. The clinical and endoscopic spectrum of the watermelon stomach. J Clin Gastroenterol. 1992;15(3):256–63.

    Article  CAS  PubMed  Google Scholar 

  96. Ward EM, Raimondo M, Rosser BG, Wallace MB, Dickson RD. Prevalence and natural history of gastric antral vascular ectasia in patients undergoing orthotopic liver transplantation. J Clin Gastroenterol. 2004;38(10):898–900. https://doi.org/10.1097/00004836–200411000–00013.

    Article  PubMed  Google Scholar 

  97. Tobin RW, Hackman RC, Kimmey MB, Durtschi B, Hayashi A, Malik R, et al. Bleeding from gastric antral vascular ectasia in marrow transplant patients. Gastrointest Endosc. 1996;44(3):223–9. https://doi.org/10.1016/S0016–5107(96)70155–4.

    Article  CAS  PubMed  Google Scholar 

  98. Smith E, Tekola B, Patrie J, Cornella S, Caldwell S. Clinical characterization of gastric antral vascular ectasia: a potential manifestation of the metabolic syndrome. Am J Med. 2016;129(12):1329 e19–23. https://doi.org/10.1016/j.amjmed.2016.07.007.

    Article  Google Scholar 

  99. Hudson C, Fontenot E, Landreneau S. Gastric antral vascular ectasia presenting as a polypoid mass in a patient with cirrhosis. Gastrointest Endosc. 2017; https://doi.org/10.1016/j.gie.2017.08.002.

    Article  PubMed  Google Scholar 

  100. Selinger CP, Ang YS. Gastric antral vascular ectasia (GAVE): an update on clinical presentation, pathophysiology and treatment. Digestion. 2008;77(2):131–7. https://doi.org/10.1159/000124339.

    Article  PubMed  Google Scholar 

  101. James Sarfeh I, Tarnawski A. Portal hypertensive gastritis. Gastroenterology. 1984;86(3):592. https://doi.org/10.1016/S0016–5085(84)80052–9.

    Article  Google Scholar 

  102. Sarin SK, Sreenivas DV, Lahoti D, Saraya A. Factors influencing development of portal hypertensive gastropathy in patients with portal hypertension. Gastroenterology. 1992;102(3):994–9.

    Article  CAS  PubMed  Google Scholar 

  103. Parikh SS, Desai SB, Prabhu SR, Trivedi MH, Shankaran K, Bhukhanwala FA, et al. Congestive Gastropathy: factors influencing development, endoscopic features, helicobacter pylori infection, and microvessel changes. Am J Gastroenterol. 1994;89(7):1036–42. https://doi.org/10.1111/j.1572–0241.1994.tb03219.x.

    Article  CAS  PubMed  Google Scholar 

  104. Primignani M, Carpinelli L, Preatoni P, Battaglia G, Carta A, Prada A, et al. Natural history of portal hypertensive gastropathy in patients with liver cirrhosis. Gastroenterology. 2000;119(1):181–7. https://doi.org/10.1053/gast.2000.8555.

    Article  CAS  PubMed  Google Scholar 

  105. Thuluvath PJ, Yoo HY. Portal hypertensive gastropathy. Am J Gastroenterol. 2002;97(12):2973–8. https://doi.org/10.1016/S0002–9270(02)05511–9.

    Article  PubMed  Google Scholar 

  106. Sogaard KK, Astrup LB, Vilstrup H, Gronbaek H. Portal vein thrombosis; risk factors, clinical presentation and treatment. BMC Gastroenterol. 2007;7 https://doi.org/10.1186/1471–230X-7–34.

  107. Kamath PS, Lacerda M, Ahlquist DA, McKusick MA, Andrews JC, Nagorney DA. Gastric mucosal responses to intrahepatic portosystemic shunting in patients with cirrhosis. Gastroenterology. 2000;118(5):905–11. https://doi.org/10.1016/S0016–5085(00)70176–4.

    Article  CAS  PubMed  Google Scholar 

  108. Cubillas R, Rockey DC. Portal hypertensive gastropathy: a review. Liver Int. 2010;30(8):1094–102. https://doi.org/10.1111/j.1478–3231.2010.02286.x.

    Article  CAS  PubMed  Google Scholar 

  109. Ohta M, Yamaguchi S, Gotoh N, Tomikawa M. Pathogenesis of portal hypertensive gastropathy: a clinical and experimental review. Surgery. 2002;131(1):S165–S70. https://doi.org/10.1067/msy.2002.119499.

    Article  PubMed  Google Scholar 

  110. Ohta M, Higashi MHH, Ueno K, Tomikawa M, Kishihara F, Kawanaka H, et al. Portal and gastric mucosal hemodynamics in cirrhotic patients with portal-hypertensive gastropathy. Hepatology. 1994;20(6):1432–6. https://doi.org/10.1002/hep.1840200609.

    Article  CAS  PubMed  Google Scholar 

  111. Massoni F, Ricci L, Pelosi M, Ricci S. The portal hypertensive Gastropathy: a case and review of literature. J Clin Diagn Res. 2016;10(6):HD01–2. https://doi.org/10.7860/JCDR/2016/14489.7942.

    Article  PubMed  PubMed Central  Google Scholar 

  112. McCormack TT, Sims J, Eyre-Brook I, Kennedy H, Goepel J, Johnson AG, et al. Gastric lesions in portal hypertension: inflammatory gastritis or congestive gastropathy? Gut. 1985;26(11):1226–32. https://doi.org/10.1136/gut.26.11.1226.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. Han S, Chaudhary N, Wassef W. Portal hypertensive gastropathy and gastric antral vascular ectasia. Curr Opin Gastroenterol. 2015;31(6):506–12. https://doi.org/10.1097/MOG.0000000000000214.

    Article  PubMed  Google Scholar 

  114. Chaer RA, Helton WS. Dieulafoy’s disease. J Am Coll Surg. 2003;196(2):290–6. https://doi.org/10.1016/S1072–7515(02)01801-X.

    Article  PubMed  Google Scholar 

  115. Nguyen DC, Jackson CS. The Dieulafoy’s lesion: an update on evaluation, diagnosis, and management. J Clin Gastroenterol. 2015;49(7):541–9. https://doi.org/10.1097/MCG.0000000000000321.

    Article  PubMed  Google Scholar 

  116. Baxter M, Aly EH. Dieulafoy’s lesion: current trends in diagnosis and management. Ann R Coll Surg Engl. 2010;92(7):548–54. https://doi.org/10.1308/003588410X12699663905311.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  117. Marangoni G, Cresswell AB, Faraj W, Shaikh H, Bowles MJ. An uncommon cause of life-threatening gastrointestinal bleeding: 2 synchronous Dieulafoy lesions. J Pediatr Surg. 2009;44(2):441–3. https://doi.org/10.1016/j.jpedsurg.2008.09.033.

    Article  PubMed  Google Scholar 

  118. Juler GL, Labitzke HG, Lamb R, Allen R. The pathogenesis of Dieulafoy’s gastric erosion. Am J Gastroenterol. 1984;79(3):195–200. https://doi.org/10.1111/j.1572–0241.1984.tb05118.x.

    Article  CAS  PubMed  Google Scholar 

  119. Miko TL, Thomázy VA. The caliber persistent artery of the stomach: a unifying approach to gastric aneurysm, Dieulafoy’s lesion, and submucosal arterial malformation. Hum Pathol. 1988;19(8):914–21. https://doi.org/10.1016/S0046–8177(88)80006–6.

    Article  CAS  PubMed  Google Scholar 

  120. Stark ME, Gostout CJ, Balm RK. Clinical features and endoscopic management of Dieulafoy’s disease. Gastrointest Endosc. 1992;38(5):545–50. https://doi.org/10.1016/S0016–5107(92)70513–6.

    Article  CAS  PubMed  Google Scholar 

  121. Senger JL, Kanthan R. The evolution of Dieulafoy’s lesion since 1897: then and now-a journey through the Lens of a pediatric lesion with literature review. Gastroenterol Res Pract. 2012;2012:432517. https://doi.org/10.1155/2012/432517.

    Article  PubMed  PubMed Central  Google Scholar 

  122. Chung IK, Kim EJ, Lee MS, Kim HS, Park SH, Lee MH, et al. Bleeding Dieulafoy’s lesions and the choice of endoscopic method: comparing the hemostatic efficacy of mechanical and injection methods. Gastrointest Endosc. 2000;52(6):721–4. https://doi.org/10.1067/mge.2000.108040.

    Article  CAS  PubMed  Google Scholar 

  123. Matsui S, Kamisako T, Kudo M, Inoue R. Endoscopic band ligation for control of nonvariceal upper GI hemorrhage: comparison with bipolar electrocoagulation. Gastrointest Endosc. 2002;55(2):214–8. https://doi.org/10.1067/mge.2002.121337.

    Article  PubMed  Google Scholar 

  124. Park CH, Sohn YH, Lee WS, Joo YE, Choi SK, Rew JS, et al. The usefulness of endoscopic hemoclipping for bleeding Dieulafoy lesions. Endoscopy. 2003;35(5):388–92. https://doi.org/10.1055/s-2003–38780.

    Article  CAS  PubMed  Google Scholar 

  125. Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Kim SJ. A prospective, randomized trial of endoscopic band ligation versus endoscopic hemoclip placement for bleeding gastric Dieulafoy’s lesions. Endoscopy. 2004;36(8):677–81. https://doi.org/10.1055/s-2004–825661.

    Article  CAS  PubMed  Google Scholar 

  126. Khoury T, Rivera L. Foregut duplication cysts: a report of two cases with emphasis on embryogenesis. World J Gastroenterol. 2011;17(1):130–4. https://doi.org/10.3748/wjg.v17.i1.130.

    Article  PubMed  PubMed Central  Google Scholar 

  127. Sharma S, Nezakatgoo N, Sreenivasan P, Vanatta J, Jabbour N. Foregut cystic developmental malformation: new taxonomy and classification—unifying embryopathological concepts. Indian J Pathol Microbiol. 2009;52(4):461–72. https://doi.org/10.4103/0377–4929.56119.

    Article  PubMed  Google Scholar 

  128. Horne G, Ming-Lum C, Kirkpatrick AW, Parker RL. High-grade neuroendocrine carcinoma arising in a gastric duplication cyst: a case report with literature review. Int J Surg Pathol. 2007;15(2):187–91. https://doi.org/10.1177/1066896906295777.

    Article  PubMed  Google Scholar 

  129. Rowling JT. Some observations on gastric cysts. Br J Surg. 1959;46(199):441–5.

    Article  CAS  PubMed  Google Scholar 

  130. Holcomb Iii GW, Gheissari A, O’Neill JA Jr, Shorter NA, Bishop HC. Surgical management of alimentary tract duplications. Ann Surg. 1989;209(2):167–74.

    Article  Google Scholar 

  131. Kuraoka K, Nakayama H, Kagawa T, Ichikawa T, Yasui W. Adenocarcinoma arising from a gastric duplication cyst with invasion to the stomach: a case report with literature review. J Clin Pathol. 2004;57(4):428–31. https://doi.org/10.1136/jcp.2003.013946.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  132. Dolan RV, Remine WH, Dockerty MB. The fate of heterotopic pancreatic tissue: a study of 212 cases. Arch Surg. 1974;109(6):762–5. https://doi.org/10.1001/archsurg.1974.01360060032010.

    Article  CAS  PubMed  Google Scholar 

  133. Martinez NS, Morlock CG, Dockerty MB, Waugh JM, Weber HM. Heterotopic pancreatic tissue involving the stomach. Ann Surg. 1958;147(1):1–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  134. Chen HL, Chang WH, Shih SC, Bair MJ, Lin SC. Changing pattern of ectopic pancreas: 22 years of experience in a medical center. J Formos Med Assoc. 2008;107(12):932–6. https://doi.org/10.1016/S0929–6646(09)60016–4.

    Article  PubMed  Google Scholar 

  135. Lindtner RA, Schreiber F, Langner C. Cytokeratin 7 immunostaining facilitates recognition of pancreatic heterotopia in gastric biopsies. Pathol Int. 2007;57(8):548–50. https://doi.org/10.1111/j.1440–1827.2007.02138.x.

    Article  PubMed  Google Scholar 

  136. Distler M, Ruckert F, Aust D, Saeger HD, Grutzmann R. Pancreatic heterotopia of the duodenum: anatomic anomaly or clinical challenge? J Gastrointest Surg. 2011;15(4):631–6. https://doi.org/10.1007/s11605–011–1420–2.

    Article  PubMed  Google Scholar 

  137. Gaspar Fuentes A, Campos Tarrech JM, Fernández Burgui JL, Castells Tejón E, Ruíz Rossello J, Gómez Pérez J, et al. Pancreatic ectopias. Revista Espanola de las Enfermedades del Aparato Digestivo. 1973;39(3):255–68.

    CAS  PubMed  Google Scholar 

  138. Osanai M, Miyokawa N, Tamaki T, Yonekawa M, Kawamura A, Sawada N. Adenocarcinoma arising in gastric heterotopic pancreas: clinicopathological and immunohistochemical study with genetic analysis of a case. Pathol Int. 2001;51(7):549–54. https://doi.org/10.1046/j.1440–1827.2001.01240.x.

    Article  CAS  PubMed  Google Scholar 

  139. Chetty R, Weinreb I. Gastric neuroendocrine carcinoma arising from heterotopic pancreatic tissue. J Clin Pathol. 2004;57(3):314–7. https://doi.org/10.1136/jcp.2003.013557.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  140. Wang HH, Zeroogian JM, Spechler SJ, Goyal RK, Antonioli DA. Prevalence and significance of pancreatic acinar metaplasia at the gastroesophageal junction. Am J Surg Pathol. 1996;20(12):1507–10.

    Article  CAS  PubMed  Google Scholar 

  141. Jhala NC, Montemor M, Jhala D, Lu L, Talley L, Haber MM, et al. Pancreatic acinar cell metaplasia in autoimmune gastritis. Arch Pathol Lab Med. 2003;127(7):854–7. https://doi.org/10.1043/1543–2165(2003)127<854:PACMIA>2.0.CO;2.

    Article  PubMed  Google Scholar 

  142. Hammock L, Jorda M. Gastric endocrine pancreatic heterotopia: report of a case with histologic and immunohistochemical findings and review of the literature. Arch Pathol Lab Med. 2002;126(4):464–7.

    PubMed  Google Scholar 

  143. To T, Wajja A, Wales PW, Langer JC. Population demographic indicators associated with incidence of pyloric stenosis. Arch Pediatr Adolesc Med. 2005;159(6):520–5. https://doi.org/10.1001/archpedi.159.6.520.

    Article  PubMed  Google Scholar 

  144. Mullassery D, Perry D, Goyal A, Jesudason EC, Losty PD. Surgical practice for infantile hypertrophic pyloric stenosis in the United Kingdom and Ireland-a survey of members of the British Association of Paediatric Surgeons. J Pediatr Surg. 2008;43(6):1227–9. https://doi.org/10.1016/j.jpedsurg.2007.12.075.

    Article  PubMed  Google Scholar 

  145. Applegate MS, Druschel CM. The epidemiology of infantile hypertrophic pyloric stenosis in New York state: 1983 to 1990. Arch Pediatr Adolesc Med. 1995;149(10):1123–9. https://doi.org/10.1001/archpedi.1995.02170230077011.

    Article  CAS  PubMed  Google Scholar 

  146. Zhu J, Zhu T, Lin Z, Qu Y, Mu D. Perinatal risk factors for infantile hypertrophic pyloric stenosis: a meta-analysis. J Pediatr Surg. 2017;52(9):1389–97. https://doi.org/10.1016/j.jpedsurg.2017.02.017.

    Article  PubMed  Google Scholar 

  147. Peeters B, Benninga MA, Hennekam RC. Infantile hypertrophic pyloric stenosis—genetics and syndromes. Nat Rev Gastroenterol Hepatol. 2012;9(11):646–60. https://doi.org/10.1038/nrgastro.2012.133.

    Article  CAS  PubMed  Google Scholar 

  148. Wayne C, Hung JH, Chan E, Sedgwick I, Bass J, Nasr A. Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. J Pediatr Surg. 2016;51(5):779–82. https://doi.org/10.1016/j.jpedsurg.2016.02.021.

    Article  PubMed  Google Scholar 

  149. Eberly MD, Eide MB, Thompson JL, Nylund CM. Azithromycin in early infancy and pyloric stenosis. Pediatrics. 2015;135(3):483–8. https://doi.org/10.1542/peds.2014–2026.

    Article  PubMed  Google Scholar 

  150. Poon TS, Zhang AL, Cartmill T, Cass DT. Changing patterns of diagnosis and treatment of infantile hypertrophic pyloric stenosis: a clinical audit of 303 patients. J Pediatr Surg. 1996;31(12):1611–5.

    Article  CAS  PubMed  Google Scholar 

  151. Panteli C. New insights into the pathogenesis of infantile pyloric stenosis. Pediatr Surg Int. 2009;25(12):1043–52. https://doi.org/10.1007/s00383–009–2484-x.

    Article  PubMed  Google Scholar 

  152. Taylor ND, Cass DT, Holland AJA. Infantile hypertrophic pyloric stenosis: has anything changed? J Paediatr Child Health. 2013;49(1):33–7. https://doi.org/10.1111/jpc.12027.

    Article  PubMed  Google Scholar 

  153. Hernanz-Schulman M. Infantile hypertrophic pyloric stenosis. Radiology. 2003;227(2):319–31. https://doi.org/10.1148/radiol.2272011329.

    Article  PubMed  Google Scholar 

  154. Rolle U, Piaseczna-Piotrowska A, Puri P. Interstitial cells of Cajal in the normal gut and in intestinal motility disorders of childhood. Pediatr Surg Int. 2007;23(12):1139–52. https://doi.org/10.1007/s00383–007–2022–7.

    Article  PubMed  Google Scholar 

  155. Aspelund G, Langer JC. Current management of hypertrophic pyloric stenosis. Semin Pediatr Surg. 2007;16(1):27–33. https://doi.org/10.1053/j.sempedsurg.2006.10.004.

    Article  PubMed  Google Scholar 

  156. Perger L, Fuchs JR, Komidar L, Mooney DP. Impact of surgical approach on outcome in 622 consecutive pyloromyotomies at a pediatric teaching institution. J Pediatr Surg. 2009;44(11):2119–25. https://doi.org/10.1016/j.jpedsurg.2009.02.067.

    Article  PubMed  Google Scholar 

  157. Chalya PL, Manyama M, Kayange NM, Mabula JB, Massenga A. Infantile hypertrophic pyloric stenosis at a tertiary care hospital in Tanzania: a surgical experience with 102 patients over a 5-year period. BMC Res Notes. 2015;8:690. https://doi.org/10.1186/s13104–015–1660–4.

    Article  PubMed  PubMed Central  Google Scholar 

  158. Carmack SW, Genta RM, Schuler CM, Saboorian MH. The current spectrum of gastric polyps: a 1-year national study of over 120,000 patients. Am J Gastroenterol. 2009;104(6):1524–32. https://doi.org/10.1038/ajg.2009.139.

    Article  PubMed  Google Scholar 

  159. Cao H, Wang B, Zhang Z, Zhang H, Qu R. Distribution trends of gastric polyps: an endoscopy database analysis of 24121 northern Chinese patients. J Gastroenterol Hepatol. 2012;27(7):1175–80. https://doi.org/10.1111/j.1440–1746.2012.07116.x.

    Article  PubMed  Google Scholar 

  160. Archimandritis A, Spiliadis C, Tzivras M, Vamvakousis B, Davaris P, Manika Z, et al. Gastric epithelial polyps: a retrospective endoscopic study of 12974 symptomatic patients. Ital J Gastroenterol. 1996;28(7):387–90.

    CAS  PubMed  Google Scholar 

  161. Islam RS, Patel NC, Lam-Himlin D, Nguyen CC. Gastric polyps: a review of clinical, endoscopic, and histopathologic features and management decisions. Gastroenterol Hepatol. 2013;9(10):640–51.

    Google Scholar 

  162. Gencosmanoglu R, Sen-Oran E, Kurtkaya-Yapicier O, Tozun N. Xanthelasmas of the upper gastrointestinal tract. J Gastroenterol. 2004;39(3):215–9. https://doi.org/10.1007/s00535–003–1288–3.

    Article  PubMed  Google Scholar 

  163. Chandan VS, Wang W, Landas SK. Gastric lipid islands. Arch Pathol Lab Med. 2004;128(8):937–8. https://doi.org/10.1043/1543–2165(2004)128<937:GLI>2.0.CO;2.

    Article  PubMed  Google Scholar 

  164. Hori S, Tsutsumi Y. Helicobacter pylori infection in gastric xanthomas: Immunohistochemical analysis of 145 lesions. Pathol Int. 1996;46(8):589–93.

    Article  CAS  PubMed  Google Scholar 

  165. Isomoto H, Mizuta Y, Inoue K, Matsuo T, Hayakawa T, Miyazaki M, et al. A close relationship between helicobacter pylori infection and gastric xanthoma. Scand J Gastroenterol. 1999;34(4):346–52. https://doi.org/10.1080/003655299750026344.

    Article  CAS  PubMed  Google Scholar 

  166. Yi SY. Dyslipidemia and H pylori in gastric xanthomatosis. World J Gastroenterol. 2007;13(34):4598–601.

    Article  PubMed  PubMed Central  Google Scholar 

  167. Shibukawa N, Ouchi S, Wakamatsu S, Wakahara Y, Kaneko A. Gastric xanthoma is a predictive marker for metachronous and synchronous gastric cancer. World J Gastrointest Oncol. 2017;9(8):327–32. https://doi.org/10.4251/wjgo.v9.i8.327.

    Article  PubMed  PubMed Central  Google Scholar 

  168. Kitamura S, Muguruma N, Okamoto K, Tanahashi T, Fukuya A, Tanaka K, et al. Clinicopathological assessment of gastric xanthoma as potential predictive marker of gastric Cancer. Digestion. 2017;96(4):199–206. https://doi.org/10.1159/000481346.

    Article  PubMed  Google Scholar 

  169. Abraham SC, Singh VK, Yardley JH, Wu TT. Hyperplastic polyps of the stomach: associations with histologic patterns of gastritis and gastric atrophy. Am J Surg Pathol. 2001;25(4):500–7. https://doi.org/10.1097/00000478–200104000–00010.

    Article  CAS  PubMed  Google Scholar 

  170. Goddard AF, Badreldin R, Pritchard DM, Walker MM, Warren B. The management of gastric polyps. Gut. 2010;59(9):1270–6. https://doi.org/10.1136/gut.2009.182089.

    Article  PubMed  Google Scholar 

  171. Amaro R, Neff GW, Karnam US, Tzakis AG, Raskin JB. Acquired hyperplastic gastric polyps in solid organ transplant patients. Am J Gastroenterol. 2002;97(9):2220–4. https://doi.org/10.1016/S0002–9270(02)04332–0.

    Article  PubMed  Google Scholar 

  172. Jewell KD, Toweill DL, Swanson PE, Upton MP, Yeh MM. Gastric hyperplastic polyps in post transplant patients: a clinicopathologic study. Mod Pathol. 2008;21(9):1108–12. https://doi.org/10.1038/modpathol.2008.87.

    Article  PubMed  Google Scholar 

  173. Gonzalez-Obeso E, Fujita H, Deshpande V, Ogawa F, Lisovsky M, Genevay M, et al. Gastric hyperplastic polyps: a heterogeneous clinicopathologic group including a distinct subset best categorized as mucosal prolapse polyp. Am J Surg Pathol. 2011;35(5):670–7. https://doi.org/10.1097/PAS.0b013e3182127d2b.

    Article  PubMed  Google Scholar 

  174. Boncher J, Bronner M, Goldblum JR, Liu X. Reticulin staining clarifies florid benign signet ring cell change with mitotic activity in a penetrating gastric ulcer. Am J Surg Pathol. 2011;35(5):762–6. https://doi.org/10.1097/PAS.0b013e318213f833.

    Article  PubMed  Google Scholar 

  175. Ohkusa T, Takashimizu I, Fujiki K, Suzuki S, Shimoi K, Horiuchi T, et al. Disappearance of hyperplastic polyps in the stomach after eradication of helicobacter pylori: a randomized, controlled trial. Ann Intern Med. 1998;129(9):712–5.

    Article  CAS  PubMed  Google Scholar 

  176. Ljubičić N, Banić M, Kujundžić M, Antić Z, Vrkljan M, Kovačević I, et al. The effect of eradicating helicobacter pylori infection on the course of adenomatous and hyperplastic gastric polyps. Eur J Gastroenterol Hepatol. 1999;11(7):727–30.

    Article  PubMed  Google Scholar 

  177. Daibo M, Itabashi M, Hirota T. Malignant transformation of gastric hyperplastic polyps. Am J Gastroenterol. 1987;82(10):1016–25.

    CAS  PubMed  Google Scholar 

  178. Han AR, Sung CO, Kim KM, Park CK, Min BH, Lee JH, et al. The clinicopathological features of gastric hyperplastic polyps with neoplastic transformations: a suggestion of indication for endoscopic polypectomy. Gut Liver. 2009;3(4):271–5. https://doi.org/10.5009/gnl.2009.3.4.271.

    Article  PubMed  PubMed Central  Google Scholar 

  179. Hattori T. Morphological range of hyperplastic polyps and carcinomas arising in hyperplastic polyps of the stomach. J Clin Pathol. 1985;38(6):622–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  180. Dirschmid K, Platz-Baudin C, Stolte M. Why is the hyperplastic polyp a marker for the precancerous condition of the gastric mucosa? Virchows Arch. 2006;448(1):80–4. https://doi.org/10.1007/s00428–005–0068–2.

    Article  PubMed  Google Scholar 

  181. Offerhaus GJA, Billaud M, Gruber SB. Peutz-Jehgers syndrome. Tumours of the Digestive System. Editors Bosman FT, Carneiro F, Hruban RH and Theise ND, IARC, Lyon, 2010:166–70.

    Google Scholar 

  182. Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW. ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol. 2015;110(2):223–62. https://doi.org/10.1038/ajg.2014.435.

    Article  PubMed  PubMed Central  Google Scholar 

  183. Brosens LAA, van Hattem WA, Jansen M, de Leng WWJ, Giardiello FM, Offerhaus GJA. Gastrointestinal polyposis syndromes. Curr Mol Med. 2007;7(1):29–46. https://doi.org/10.2174/156652407779940404.

    Article  CAS  PubMed  Google Scholar 

  184. McGarrity TJ, Kulin HE, Zaino RJ. Peutz-Jeghers syndrome. Am J Gastroenterol. 2000;95(3):596–604. https://doi.org/10.1016/S0002–9270(99)00890–4.

    Article  CAS  PubMed  Google Scholar 

  185. Lam-Himlin D, Park JY, Cornish TC, Shi C, Montgomery E. Morphologic characterization of syndromic gastric polyps. Am J Surg Pathol. 2010;34(11):1656–62. https://doi.org/10.1097/PAS.0b013e3181f2b1f1.

    Article  PubMed  Google Scholar 

  186. Van Lier MGF, Westerman AM, Wagner A, Looman CWN, Wilson JHP, De Rooij FWM, et al. High cancer risk and increased mortality in patients with Peutz—Jeghers syndrome. Gut. 2011;60(2):141–7. https://doi.org/10.1136/gut.2010.223750.

    Article  PubMed  Google Scholar 

  187. Giardiello FM, Brensinger JD, Tersmette AC, Goodman SN, Petersen GM, Booker SV, et al. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology. 2000;119(6):1447–53. https://doi.org/10.1053/gast.2000.20228.

    Article  CAS  PubMed  Google Scholar 

  188. Jansen M, De Leng WWJ, Baas AF, Myoshi H, Mathus-Vliegen L, Taketo MM, et al. Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis. Gut. 2006;55(1):1–5. https://doi.org/10.1136/gut.2005.069062.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  189. Langeveld D, Jansen M, De Boer DV, Van Sprundel M, Brosens LAA, Morsink FH, et al. Aberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt. Gut. 2012;61(6):839–46. https://doi.org/10.1136/gutjnl-2011–300622.

    Article  CAS  PubMed  Google Scholar 

  190. Howe JR, Roth S, Ringold JC, Summers RW, Järvinen HJ, Sistonen P, et al. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science. 1998;280(5366):1086–8. https://doi.org/10.1126/science.280.5366.1086.

    Article  CAS  PubMed  Google Scholar 

  191. Howe JR, Ringold JC, Summers RW, Mitros FA, Nishimura DY, Stone EM. A gene for familial juvenile polyposis maps to chromosome 18q21.1. Am J Hum Genet. 1998;62(5):1129–36. https://doi.org/10.1086/301840.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  192. Howe JR, Bair JL, Sayed MG, Anderson ME, Mitros FA, Petersen GM, et al. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet. 2001;28(2):184–7. https://doi.org/10.1038/88919.

    Article  CAS  PubMed  Google Scholar 

  193. Aretz S, Stienen D, Uhlhaas S, Stolte M, Entius MM, Loff S, et al. High proportion of large genomic deletions and a genotype-phenotype update in 80 unrelated families with juvenile polyposis syndrome. J Med Genet. 2007;44(11):702–9. https://doi.org/10.1136/jmg.2007.052506.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  194. Sayed MG, Ahmed AF, Ringold JR, Anderson ME, Bair JL, Mitros FA, et al. Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis. Ann Surg Oncol. 2002;9(9):901–6.

    Article  CAS  PubMed  Google Scholar 

  195. Sweet K, Willis J, Zhou XP, Gallione C, Sawada T, Alhopuro P, et al. Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. J Am Med Assoc. 2005;294(19):2465–73. https://doi.org/10.1001/jama.294.19.2465.

    Article  CAS  Google Scholar 

  196. Schreibman IR, Baker M, Amos C, McGarrity TJ. The hamartomatous polyposis syndromes: a clinical and molecular review. Am J Gastroenterol. 2005;100(2):476–90. https://doi.org/10.1111/j.1572–0241.2005.40237.x.

    Article  PubMed  Google Scholar 

  197. Offerhaus GJA, Howe JR. Juvenile polyposis. WHO Classification of Tumours of the Digestive System 2010:166–7.

    Google Scholar 

  198. Ma C, Giardiello FM, Montgomery EA. Upper tract juvenile polyps in juvenile polyposis patients: dysplasia and malignancy are associated with foveolar, intestinal, and pyloric differentiation. Am J Surg Pathol. 2014;38(12):1618–26.

    Article  PubMed  PubMed Central  Google Scholar 

  199. Gonzalez RS, Adsay V, Graham RP, Shroff SG, Feely MM, Drage MG, et al. Massive gastric juvenile-type polyposis: a clinicopathological analysis of 22 cases. Histopathology. 2017;70(6):918–28. https://doi.org/10.1111/his.13149.

    Article  PubMed  Google Scholar 

  200. Lawless ME, Toweill DL, Jewell KD, Jain D, Lamps L, Krasinskas AM, et al. Massive gastric juvenile polyposis: a clinicopathologic study using SMAD4 immunohistochemistry. Am J Clin Pathol. 2017;147(4):390. https://doi.org/10.1093/ajcp/aqx015.

    Article  CAS  PubMed  Google Scholar 

  201. Howe JR, Mitros FA, Summers RW. The risk of gastrointestinal carcinoma in familial juvenile polyposis. Ann Surg Oncol. 1998;5(8):751–6.

    Article  CAS  PubMed  Google Scholar 

  202. Slavik T, Montgomery EA. Cronkhite-Canada syndrome six decades on: the many faces of an enigmatic disease. J Clin Pathol. 2014;67(10):891–7. https://doi.org/10.1136/jclinpath-2014–202488.

    Article  PubMed  Google Scholar 

  203. Ward EM, Wolfsen HC. Review article: the non-inherited gastrointestinal polyposis syndromes. Aliment Pharmacol Ther. 2002;16(3):333–42. https://doi.org/10.1046/j.1365–2036.2002.01172.x.

    Article  CAS  PubMed  Google Scholar 

  204. Daniel ES, Ludwig SL, Lewin KJ, Ruprecht RM, Rajacich GM, Schwabe AD. The cronkhite-Canada syndrome: an analysis of clinical and pathologic features and therapy in 55 patients. Medicine (United States). 1982;61(5):293–309.

    CAS  Google Scholar 

  205. Riegert-Johnson DL, Osborn N, Smyrk T, Boardman LA. Cronkhite-Canada syndrome hamartomatous polyps are infiltrated with IgG4 plasma cells [1]. Digestion. 2007;75(2–3):96–7. https://doi.org/10.1159/000102963.

    Article  PubMed  Google Scholar 

  206. Sweetser S, Ahlquist DA, Osborn NK, Sanderson SO, Smyrk TC, Chari ST, et al. Clinicopathologic features and treatment outcomes in Cronkhite-Canada syndrome: support for autoimmunity. Dig Dis Sci. 2012;57(2):496–502. https://doi.org/10.1007/s10620–011–1874–9.

    Article  PubMed  Google Scholar 

  207. Burke AP, Sobin LH. The pathology of Cronkhite-Canada polyps. A comparison to juvenile polyposis. Am J Surg Pathol. 1989;13(11):940–6. https://doi.org/10.1097/00000478–198911000–00004.

    Article  CAS  PubMed  Google Scholar 

  208. Wolfsen HC, Carpenter HA, Talley NJ. Menetrier’s disease: a form of hypertrophic gastropathy or gastritis? Gastroenterology. 1993;104(5):1310–9. https://doi.org/10.1016/0016–5085(93)90339-E.

    Article  CAS  PubMed  Google Scholar 

  209. Isobe T, Kobayashi T, Hashimoto K, Kizaki J, Miyagi M, Aoyagi K, et al. Cronkhite-Canada syndrome complicated with multiple gastric cancers and multiple colon adenomas. Am J Case Rep. 2013;14:120–8. https://doi.org/10.12659/AJCR.889083.

    Article  PubMed  PubMed Central  Google Scholar 

  210. Egawa T, Kubota T, Otani Y, Kurihara N, Abe S, Kimata M, et al. Surgically treated Cronkhite-Canada syndrome associated with gastric cancer. Gastric Cancer. 2000;3(3):156–60.

    Article  PubMed  Google Scholar 

  211. Watanabe T, Kudo M, Shirane H, Kashida H, Tomita S, Orino A, et al. Cronkhite-Canada syndrome associated with triple gastric cancers: a case report. Gastrointest Endosc. 1999;50(5):688–91.

    Article  CAS  PubMed  Google Scholar 

  212. Chadalavada R, Brown DK, Walker AN, Sedghi S. Cronkhite-Canada syndrome: sustained remission after corticosteroid treatment. Am J Gastroenterol. 2003;98(6):1444–6. https://doi.org/10.1111/j.1572–0241.2003.07509.x.

    Article  PubMed  Google Scholar 

  213. Goto A. Cronkhite-Canada syndrome: epidemiological study of 110 cases reported in Japan. Archiv fur Japanische Chirurgie. 1995;64(1):3–14.

    CAS  PubMed  Google Scholar 

  214. Pilarski R, Stephens JA, Noss R, Fisher JL, Prior TW. Predicting PTEN mutations: an evaluation of cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome clinical features. J Med Genet. 2011;48(8):505–12. https://doi.org/10.1136/jmg.2011.088807.

    Article  CAS  PubMed  Google Scholar 

  215. Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E. Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria. J Natl Cancer Inst. 2013;105(21):1607–16. https://doi.org/10.1093/jnci/djt277.

    Article  CAS  PubMed  Google Scholar 

  216. Ngeow J, Sesock K, Eng C. Clinical implications for Germline PTEN Spectrum disorders. Endocrinol Metab Clin N Am. 2017;46(2):503–17. https://doi.org/10.1016/j.ecl.2017.01.013.

    Article  Google Scholar 

  217. Eng C. Will the real Cowden syndrome please stand up: revised diagnostic criteria. J Med Genet. 2000;37(11):828–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  218. Pilarski R, Eng C. Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome. J Med Genet. 2004;41(5):323–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  219. Al-Thihli K, Palma L, Marcus V, Cesari M, Kushner YB, Barkun A, et al. A case of Cowden’s syndrome presenting with gastric carcinomas and gastrointestinal polyposis. Nat Clin Pract Gastroenterol Hepatol. 2009;6(3):184–9. https://doi.org/10.1038/ncpgasthep1359.

    Article  PubMed  Google Scholar 

  220. Hamby LS, Lee EY, Schwartz RW. Parathyroid adenoma and gatric carcinoma as manifestations of cowden’s disease. Surgery. 1995;118(1):115–7. https://doi.org/10.1016/S0039–6060(05)80018–2.

    Article  CAS  PubMed  Google Scholar 

  221. Doglioni C, Laurino L, Dei Tos AP, De Boni M, Franzin G, Braidotti P, et al. Pancreatic (acinar) metaplasia of the gastric mucosa: histology, ultrastructure, immunocytochemistry, and clinicopathologic correlations of 101 cases. Am J Surg Pathol. 1993;17(11):1134–43. https://doi.org/10.1097/00000478–199311000–00006.

    Article  CAS  PubMed  Google Scholar 

  222. Krishnamurthy S, Dayal Y. Pancreatic metaplasia in Barrett’s esophagus: an immunohistochemical study. Am J Surg Pathol. 1995;19(10):1172–80.

    Article  CAS  PubMed  Google Scholar 

  223. Integlia MJ. Pancreatic metaplasia of the gastric mucosa in pediatric patients. Am J Gastroenterol. 1997;92(9):1553–6.

    CAS  PubMed  Google Scholar 

  224. Krishnamurthy S, Integlia MJ, Grand RJ, Dayal Y. Pancreatic acinar cell clusters in pediatric gastric mucosa. Am J Surg Pathol. 1998;22(1):100–5. https://doi.org/10.1097/00000478–199801000–00013.

    Article  CAS  PubMed  Google Scholar 

  225. Jhala N, Jhala D, West B, Atkinson BF, Haber MH. Pancreatic (acinar cell) metaplasia or early pancreatic heterotopia? Am J Clin Pathol. 1994;101:385.

    Google Scholar 

  226. Johansson J, Hakansson HO, Mellblom L, Kempas A, Kjellen G, Brudin L, et al. Pancreatic acinar metaplasia in the distal oesophagus and the gastric cardia: prevalence, predictors and relation to GORD. J Gastroenterol. 2010;45(3):291–9. https://doi.org/10.1007/s00535–009–0161–4.

    Article  PubMed  Google Scholar 

  227. Littler ER, Gleibermann E. Gastritis cystica polyposa. (Gastric mucosal prolapse at gastroenterostomy site, with cystic and infiltrative epithelial hyperplasia). Cancer. 1972;29(1):205–9. https://doi.org/10.1002/1097–0142(197201)29:1<205::AID-CNCR2820290130>3.0.CO;2-J.

    Article  CAS  PubMed  Google Scholar 

  228. Qizilbash AH. Gastritis cystica and carcinoma arising in old gastrojejunostomy stoma. Can Med Assoc J. 1975;112(12):1432–3.

    CAS  PubMed  PubMed Central  Google Scholar 

  229. Tomizuka T, Mazaki T, Mado K, Henmi A, Ishii Y, Masuda H, et al. A case of gastritis cystica profunda. Surgery. 2008;143(3):449–50. https://doi.org/10.1016/j.surg.2007.02.009.

    Article  PubMed  Google Scholar 

  230. Béchade D, Desramé J, Algayres JP. Gastritis cystica profunda in a patient with no history of gastric surgery. Endoscopy. 2007;39(Suppl 1):E80–1. https://doi.org/10.1055/s-2006–945070.

    Article  PubMed  Google Scholar 

  231. Xu G, Peng C, Li X, Zhang W, Lv Y, Ling T, et al. Endoscopic resection of gastritis cystica profunda: preliminary experience with 34 patients from a single center in China. Gastrointest Endosc. 2015;81(6):1493–8. https://doi.org/10.1016/j.gie.2014.11.017.

    Article  PubMed  Google Scholar 

  232. Yu XF, Guo LW, Chen ST, Teng LS. Gastritis cystica profunda in a previously unoperated stomach: a case report. World J Gastroenterol. 2015;21(12):3759–62. https://doi.org/10.3748/wjg.v21.i12.3759.

    Article  PubMed  PubMed Central  Google Scholar 

  233. Franzin G, Novelli P. Gastritis cystica profunda. Histopathology. 1981;5(5):535–47. https://doi.org/10.1111/j.1365–2559.1981.tb01817.x.

    Article  CAS  PubMed  Google Scholar 

  234. Odze RD, Greenson J, Lauwers G, Goldblum J. Gastritis cystica profunda versus invasive adenocarcinoma. Am J Surg Pathol. 2012;36(2):316. https://doi.org/10.1097/PAS.0b013e31823edb3b.

    Article  PubMed  Google Scholar 

  235. Wang L, Yan H, Cao DC, Huo L, Huo HZ, Wang B, et al. Gastritis cystica profunda recurrence after surgical resection: 2-year follow-up. World J Surg Oncol. 2014;12(1) https://doi.org/10.1186/1477–7819–12–133.

  236. Fonde EC, Rodning CB. Gastritis cystica profunda. Am J Gastroenterol. 1986;81(6):459–64. https://doi.org/10.1111/j.1572–0241.1986.tb01523.x.

    Article  CAS  PubMed  Google Scholar 

  237. Franzin G, Musola R, Zamboni G, Manfrini C. Gastritis cystica polyposa: a possible precancerous lesion. Tumori. 1985;71(1):13–8.

    Article  CAS  PubMed  Google Scholar 

  238. Choi MG, Jeong JY, Kim KM, Bae JM, Noh JH, Sohn TS, et al. Clinical significance of gastritis cystica profunda and its association with Epstein-Barr virus in gastric cancer. Cancer. 2012;118(21):5227–33. https://doi.org/10.1002/cncr.27541.

    Article  PubMed  Google Scholar 

  239. Park CH, Park JM, Jung CK, Kim DB, Kang SH, Lee SW, et al. Early gastric cancer associated with gastritis cystica polyposa in the unoperated stomach treated by endoscopic submucosal dissection. Gastrointest Endosc. 2009;69(6):e47–50. https://doi.org/10.1016/j.gie.2008.10.020.

    Article  PubMed  Google Scholar 

  240. Deery S, Yates R, Hata J, Shi C, Parikh AA. Gastric adenocarcinoma associated with gastritis cystica profunda in an unoperated stomach. Am Surg. 2012;78(8):E379–E80.

    PubMed  Google Scholar 

  241. Gorospe M, Fadare O. Gastric mucosal calcinosis: clinicopathologic considerations. Adv Anat Pathol. 2007;14(3):224–8. https://doi.org/10.1097/PAP.0b013e31805048ea.

    Article  PubMed  Google Scholar 

  242. Greenson JK, Trinidad SB, Pfeil SA, Brainard JA, McBride PT, Colijn HO, et al. Gastric mucosal calcinosis: calcified aluminum phosphate deposits secondary to aluminum-containing antacids or sucralfate therapy in organ transplant patients. Am J Surg Pathol. 1993;17(1):45–50. https://doi.org/10.1097/00000478–199301000–00005.

    Article  CAS  PubMed  Google Scholar 

  243. Kuzela DC, Huffer WE, Conger JD, Winter SD, Hammond WS. Soft tissue calcification in chronic dialysis patients. Am J Pathol. 1977;86(2):403–24.

    CAS  PubMed  PubMed Central  Google Scholar 

  244. Ou Tim L, Hurwitz S, Tuch P. The endoscopic diagnosis of gastric calcification. J Clin Gastroenterol. 1982;4(3):213–5.

    Article  CAS  PubMed  Google Scholar 

  245. Saab S, Venkataramani A, Behling CA, Savides TJ. Gastric mucosal calcinosis in a patient with dyspepsia. J Clin Gastroenterol. 1996;22(2):156–7. https://doi.org/10.1097/00004836–199603000–00020.

    Article  CAS  PubMed  Google Scholar 

  246. Nayak HK, Mohindra S, Iqbal S, Saraswat VA, Agarwal V, Pande G. Gastric mucosal calcinosis mimicking malignancy. Am J Gastroenterol. 2016;111(10):1380. https://doi.org/10.1038/ajg.2016.274.

    Article  PubMed  Google Scholar 

  247. Ebert EC, Nagar M. Gastrointestinal manifestations of amyloidosis. Am J Gastroenterol. 2008;103(3):776–87. https://doi.org/10.1111/j.1572–0241.2007.01669.x.

    Article  PubMed  Google Scholar 

  248. Menke DM, Kyle RA, Fleming CR, Wolfe JT III, Kurtin PJ, Oldenburg WA. Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis. Mayo Clin Proc. 1993;68(8):763–7. https://doi.org/10.1016/S0025–6196(12)60634-X.

    Article  CAS  PubMed  Google Scholar 

  249. Said SM, Grogg KL, Smyrk TC. Gastric amyloidosis: clinicopathological correlations in 79 cases from a single institution. Human Pathology. 2015;46(4):491–8. Original contribution. https://doi.org/10.1016/j.humpath.2014.12.009.

    Article  CAS  PubMed  Google Scholar 

  250. Seon CS, Park YS, Jung YM, Choi JH, Son BK, Ahn SB, et al. Gastric outlet obstruction due to gastric amyloidosis mimicking malignancy in a patient with ankylosing spondylitis. Clin Endosc. 2013;46(6):651–5. https://doi.org/10.5946/ce.2013.46.6.651.

    Article  PubMed  PubMed Central  Google Scholar 

  251. Khan Z, Darr U, Renno A, Tiwari A, Sofi A, Nawras A. Massive upper and lower GI bleed from simultaneous primary (AL) amyloidosis of the stomach and transverse colon in a patient with multiple myeloma. Case Rep Gastroenterol. 2017;11(3):625–31. https://doi.org/10.1159/000480073.

    Article  PubMed  PubMed Central  Google Scholar 

  252. Rivera R, Kaul V, DeCross A, Whitney-Miller C. Primary gastric amyloidosis presenting as an isolated gastric mass. Gastrointest Endosc. 2012;76(1):186–7. https://doi.org/10.1016/j.gie.2012.02.059.

    Article  PubMed  Google Scholar 

  253. Tada S, Lida M, Iwashita A, Matsui T, Fuchigami T, Yamamoto T, et al. Endoscopic and biopsy findings of the upper digestive tract in patients with amyloidosis. Gastrointest Endosc. 1990;36(1):10–4. https://doi.org/10.1016/S0016–5107(90)70913–3.

    Article  CAS  PubMed  Google Scholar 

  254. Jimenez-Zepeda VH, Vajpeyi R, John R, Trudel S. Light chain deposition disease affecting the gastrointestinal tract in the setting of post-living donor kidney transplantation. Int J Hematol. 2012;96(1):125–31. https://doi.org/10.1007/s12185–012–1090–1.

    Article  PubMed  Google Scholar 

  255. Kwon JH, Jeong SH, Kim JW, Bang SM, Kim H, Kim YH, et al. Case report: a case of light chain deposition disease involving liver and stomach with chronic hepatitis C virus infection and hepatocellular carcinoma. J Med Virol. 2011;83(5):810–4. https://doi.org/10.1002/jmv.22050.

    Article  PubMed  Google Scholar 

  256. Conte D, Velio P, Brunelli L, Mandelli C, Cesana M, Ferrario L, et al. Stainable Iron in gastric and duodenal mucosa of primary hemochromatosis patients and alcoholics. Am J Gastroenterol. 1987;82(3):237–40. https://doi.org/10.1111/j.1572–0241.1987.tb05298.x.

    Article  CAS  PubMed  Google Scholar 

  257. Marginean EC, Bennick M, Cyczk J, Robert ME, Jain D. Gastric siderosis: patterns and significance. Am J Surg Pathol. 2006;30(4):514–20. https://doi.org/10.1097/00000478–200604000–00013.

    Article  PubMed  Google Scholar 

  258. Antunes AG, Cadilla J, Guerreiro H. Gastric siderosis as a cause of dyspepsia. BMJ Case Rep. 2016;2016 https://doi.org/10.1136/bcr-2016–216862.

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Chandan, V.S. (2019). Drugs-Induced Injury, Infections, Vascular, Congenital, and Miscellaneous Disorders. In: Zhang, L., Chandan, V., Wu, TT. (eds) Surgical Pathology of Non-neoplastic Gastrointestinal Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-15573-5_8

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