Infectious Disorders of the Duodenum and Small Bowel

  • Audrey N. SchuetzEmail author


Infectious agents causing infection of the small bowel include viruses, bacteria, fungi, and parasites. This chapter covers histopathology of small bowel infections of the duodenum and small intestine (jejunum and ileum). Infectious agents which cause disease that may result in a biopsy to obtain a diagnosis are covered in this chapter. Clinical features, histopathologic features, differential diagnosis, and treatment and prognosis are covered for each infectious entity. Parasites encompass the largest group of infectious agents leading to small intestinal disease. The nematodes Strongyloides, Anisakis, and Angiostrongylus are discussed, as is Giardia, the most common intestinal protozoan worldwide. Intestinal disease due to the coccidian parasites Cryptosporidium and Cyclospora is also described. A description of adenoviral disease and comparison of cytopathic effects of other viruses common to the intestine is provided. Whipple disease due to Tropheryma whipplei is also discussed, and a histologic differential diagnosis of this disease is provided. Finally, microsporidial small intestinal disease in immunocompromised hosts is discussed.


Duodenum Small intestine Bacteria Virus Parasite Mycobacteria Whipple Infection Small bowel Strongyloides Anisakis Angiostrongylus Cryptosporidium Cyclospora Tropheryma whipplei Microsporidiasis 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Laboratory Medicine and PathologyMayo ClinicRochesterUSA

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