Evaluation and Management of Pediatric Nephrolithiasis
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Abstract
The incidence of nephrolithiasis in pediatrics is increasing. All children with nephrolithiasis should have a complete metabolic evaluation on initial presentation, as a metabolic risk factor may be found in the majority of children. Careful consideration in pediatric nephrolithiasis of rare genetic causes of kidney stones disease should be at the forefront of the evaluation, as many of these disorders present in childhood and are associated with a lifetime of morbidities related to nephrolithiasis as well as the risk for development of chronic kidney disease. Treatment of the underlying metabolic risk factors helps prevent further stone formation and the morbidities associated with stone formation, such as pain, surgery, and chronic kidney disease.
Keywords
Pediatric Nephrolithiasis Primary hyperoxaluria Dent disease Cystinuria GeneticsReferences
- 1.Taisan GE, Ross ME, Liahi S, et al. Annual incidence of nephrolithiasis among children and adults in South Carolina from 1997–2012, with a particular increase in the adolescent female population. Clin J Am Soc Nephrol. 2016;11(3):488–96.CrossRefGoogle Scholar
- 2.Novak TE, Lakshmanan Y, Trock BJ, et al. Sex prevalence of pediatric kidney stone disease in the United States. Urology. 2009;74(1):104–7.PubMedCrossRefGoogle Scholar
- 3.Dwyer ME, Krambeck AE, Bergstralh EJ, et al. Temporal trends in incidence of kidney stones among children: a 25-year population based study. J Urol. 2012;188:247–52.PubMedPubMedCentralCrossRefGoogle Scholar
- 4.Bonzo JR, Taisan GE. The emergence of kidney stone disease during childhood—impact on adults. Curr Urol Rep. 2017;18(44):1–6.Google Scholar
- 5.Tasian GE, Kabarriti AE, Kalmus A, et al. Kidneystone recurrence among children and adolescents. J Urol. 2017;197:246–52.PubMedCrossRefGoogle Scholar
- 6.Cameron MA, Sakhaee K, Moe OW. Nephrolithiasis in children. Pediatr Nephrol. 2005;20:1587–92.PubMedCrossRefGoogle Scholar
- 7.Hoppe B, Kemper MJ. Diagnostic examination of the child with urolithiasis or nephrocalcinosis. Pediatr Nephrol. 2010;25:403–13.PubMedCrossRefGoogle Scholar
- 8.Spivacow FR, Negri AL, del Valle EE, et al. Metabolic risk factors in children with kidney stone disease. Pediatr Nephrol. 2008;23:1129–33.PubMedCrossRefGoogle Scholar
- 9.Cochat P, Pichault V, Bacchetta J, et al. Nephrolithiasis related to inborn metabolic disease. Pediatr Nephrol. 2010;25:415–24.PubMedCrossRefGoogle Scholar
- 10.Edvardsson V, Goldfarb D, Lieske J, et al. Hereditary causes of kidney stones and chronic kidney disease. Pediatr Nephrol. 2013;28:1923–42.PubMedPubMedCentralCrossRefGoogle Scholar
- 11.Braun DA, Lawson JA, Gee HY, et al. Prevalence of monogenic causes in pediatric patients with nephrolithiasis or nephrocalcinosis. Clin J Am Soc Nephrol. 2016;11(4):664–72.PubMedPubMedCentralCrossRefGoogle Scholar
- 12.Daga A, Majmundar AJ, Braun DA, Gee HY, et al. Whole exome sequencing frequently detects a monogenic cause in early onset nephrolithiasis and Nephrocalcinosis. Kidney Int. 2018;93(1):204–13.PubMedCrossRefGoogle Scholar
- 13.Guven AG, Koyun M, Baysal YE, et al. Urolithiasis in the first year of life. Pediatr Nephrol. 2010;25:129–34.PubMedCrossRefGoogle Scholar
- 14.Poito C, La Manna A, Signoriello G, Marte A. Recurrent abdominal pain in childhood urolithiasis. Pediatrics. 2009;124(6):e1088–94.CrossRefGoogle Scholar
- 15.Schell-Feith EA, Kist-van Holthe JE, van der Heijden AJ. Nephrocalcinosis in preterm infants. Pediatr Nephrol. 2010;25:221–30.PubMedCrossRefGoogle Scholar
- 16.Skolarikos A, Dellis A, Knoll T. Ureteropelvic obstruction and renal stones: etiology and treatment. Urolithiasis. 2015;43(1):5–12.PubMedCrossRefGoogle Scholar
- 17.Stephany HA, Clayton DB, Tanaka ST, et al. Development of upper tract stones in patients with congenital neurogenic bladder. J Pediatr Urol. 2014;10(1):112–7.PubMedCrossRefGoogle Scholar
- 18.Raj GV, Auge BK, Assimos D, et al. Metabolic abnormalities associated with renal calculi in patients with horseshoe kidneys. J Endourol. 2004;18(2):157–61.PubMedCrossRefGoogle Scholar
- 19.Nazzal L, Puri S, Goldfarb D. Enteric hyperoxaluria: an important cause of end-stage kidney disease. Nephrol Dial Transplant. 2016;31L:375–82.CrossRefGoogle Scholar
- 20.Asplin J. The management of patients with enteric hyperoxaluria. Urolithiasis. 2016;44:33–43.PubMedCrossRefGoogle Scholar
- 21.Gibeny E, Goldfarb D. The association of nephrolithiasis with cystic fibrosis. Am J Kidney Dis. 2003;42:1–11.CrossRefGoogle Scholar
- 22.Pober B. Williams-Beuren syndrome. N Engl J Med. 2010;362:239–52.PubMedCrossRefGoogle Scholar
- 23.Weinstein DA, Somers MJ, Wolfsdorf JI. Decreased urinary citrate excretion in type 1a glycogen storage disease. J Pediatr. 2001;138(3):378–82.PubMedCrossRefGoogle Scholar
- 24.Rake J, Visser G, Labrune P, et al. Guidelines for management of glycogen storage disease type 1—European study on glycogen storage disease type 1 (ESGSD 1). Eur J Pediatr. 2002;161(1):S112–9.PubMedCrossRefGoogle Scholar
- 25.McNally M, Pyzik P, Rubenstein J, et al. Empiric use of potassium citrate reduces kidney-stone incidence with the ketogenic diet. Pediatrics. 2009;124:e300–4.PubMedPubMedCentralCrossRefGoogle Scholar
- 26.Kossoff E, Pyzik P, Furth S, et al. Kidney stones, carbonic anhydrase inhibitors, and the ketogenic diet. Epilepsia. 2002;43(10):1168–71.PubMedCrossRefGoogle Scholar
- 27.Blank S, Scanlon KS, Sinks TH, et al. An outbreak of hypervitaminosis D associated with the overfortification of milk from a home delivery-dairy. Am J Public Health. 1995;85(5):656–9.PubMedPubMedCentralCrossRefGoogle Scholar
- 28.Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol. 2003;2(1):397–401.CrossRefGoogle Scholar
- 29.Saltel E, Angel JB, Futter NG, et al. Increased prevalence and analysis of risk factors for indinavir nephrolithiasis. J Urol. 2000;164(6):1895–7.PubMedCrossRefGoogle Scholar
- 30.Raheem O, Mirheydar H, Palazzi K, et al. Prevalence of nephrolithiasis in human immunodeficiency virus infected patients on the highly active antiretroviral therapy. J Endourol. 2012;26(8):1095–8.PubMedCrossRefGoogle Scholar
- 31.Grant MT, Eisner BH, Bechis SK. Ureteral obstruction due to radiolucent atazanavir ureteral stone. J Endourol Case Rep. 2017;3(1):152–4.PubMedPubMedCentralCrossRefGoogle Scholar
- 32.Rockwood N, Mandalia S, Bower M. Ritonavir boosted atazanavir exposure is associated with an increased rate of renal stones compared with efavirenz, ritonavir-boosted lopinavir and ritonavir-boosted darunavir. AIDS. 2011;25(13):1671–3.PubMedCrossRefGoogle Scholar
- 33.Azvi Z, Koktener A, Uras N, et al. Nephrolithiasis associated with ceftriaxone therapy a prospective study in 51 children. Arch Dis Child. 2004;11:1069–72.Google Scholar
- 34.Taylor EN, Fung TT, Curhan GC. DASH-style diet associates with reduced risk for kidney stones. J Am Soc Nephrol. 2009;20(10):2253–9.PubMedPubMedCentralCrossRefGoogle Scholar
- 35.Nouvenne A, Ticinesi A, Morelli I, et al. Fad diets and their effect on urinary stone formation. Transl Androl Urol. 2014;3(3):303–12.PubMedPubMedCentralGoogle Scholar
- 36.Lopez M, Hoppe B. History epidemiology and regional diversities of urolithaisis. Pediatr Nephrol. 2010;25:49–59.PubMedCrossRefGoogle Scholar
- 37.Coe F, Parks JH, Moore ES. Familial idiopathic hypercalciuria. NEJM. 1979;300:337–40.PubMedCrossRefGoogle Scholar
- 38.Passerotti C, Chow JS, Silva A, et al. Ultrasound versus computerized tomography for evaluation of urolithiasis. J Urol. 2009;182(4 suppl):1829–34.PubMedCrossRefGoogle Scholar
- 39.Coe F, Worcester E, Evan A. Idiopathic hypercalciuria and formation of calcium renal stones. Nat Rev Nephrol. 2016;12(9):519–33.PubMedPubMedCentralCrossRefGoogle Scholar
- 40.Hoppe B, Beck BB, Milliner DS. The primary hyperoxalurias. Kidney Int. 2009;75:1264–71.PubMedPubMedCentralCrossRefGoogle Scholar
- 41.Sumorok N, Goldfarb D. Update on cystinuria. Curr Opin Nephrol Hypertens. 2013;22(4):427–31.PubMedPubMedCentralCrossRefGoogle Scholar
- 42.Wang SS, Devuyst O, Courtoy PJ, et al. Mice lacking renal chloride channel CLC-5 are a model for Dent’s disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. Hum Mol Genet. 2000;9:2937–45.PubMedCrossRefGoogle Scholar
- 43.Hoopes RR Jr, Shrimpton AE, Knohl SJ, et al. Dent disease with mutations in OCRL1. Am J Hum Genet. 2005;76:260–7.PubMedCrossRefGoogle Scholar
- 44.Williams-Larson AW. Urinary calculi associated with purine metabolism. Uric acid nephrolithiasis. Endocrinol Metab Clin N Am. 1990;19(4):821–38.CrossRefGoogle Scholar
- 45.Torres R, Puig J, Jinnah H. Update on the phenotypic spectrum of Lesch-Nyhan disease and its attenuated variants. Curr Rheumatol Rep. 2012;14(2):189–94.PubMedPubMedCentralCrossRefGoogle Scholar
- 46.Jones DP, Mahmoud H, Chesney RW. Tumor lysis syndrome: pathogenesis and management. Pediatr Nephrol. 1995;9(2):206–12.PubMedCrossRefGoogle Scholar
- 47.Goldman SC, Holcenberg JS, Finklestein JZ, et al. Randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Blood. 2001;97(10):2998–3003.PubMedCrossRefGoogle Scholar
- 48.Edvardsson V, Palsson R, Olafsson I, et al. Clinical features and genotype of adenine phosphoribosyltransferase deficiency in Iceland. Am J Kidney Dis. 2001;38:473–90.PubMedCrossRefGoogle Scholar
- 49.Bollee G, Dollinger C, Boutaaud L, et al. Phenotype and genotype characterization of adenine phosphoribosyltransferase deficiency. J Am Soc Nephrol. 2010;21:679–88.PubMedPubMedCentralCrossRefGoogle Scholar
- 50.Matos V, van Melle G, Boulat O, et al. Urinary phosphate/creatinine, calcium/creatinine, and magnesium/creatinine ratios in a healthy pediatric population. J Pediatr. 1997;131:252–7.PubMedCrossRefGoogle Scholar
- 51.Miliner DS. Urolithiasis. In: Avner ED, Harmon WE, Niaudet P, Yoshikawa N, editors. Pediatric nephrology, Vol. 2. 6th ed. Berlin/Heidelberg: Springer; 2009. p. 1405–30.CrossRefGoogle Scholar
- 52.So NP, Osoria AV, Simon SD, et al. Normal urinary calcium/creatinine ratios in African-American and Caucasian children. Pediatr Nephrol. 2001;16:133–9.PubMedCrossRefGoogle Scholar
- 53.Polinsky MS, Kaiser BA, Baluarte HJ, et al. Renal stones and hypercalciuria. In: Barnes LA, DeVivo DC, Kaback MM, Morrow G, Oski FA, Rudolph AM, editors. Advances in pediatrics, vol. 40. St. Louis: Mosby; 1993. p. 353–84.Google Scholar
- 54.Matoo A, Goldfarb DS. Cystinuria. Semin Nephrol. 2008;28(2):181–91.CrossRefGoogle Scholar
- 55.Baum MA. Approach to stone formation in the pediatric population. Clin Rev Bone Miner Metab. 2012;10:50–60.CrossRefGoogle Scholar