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Bacilli and Agrobiotechnology: Phytostimulation and Biocontrol pp 201–215Cite as

Tapping the Potential of Metabolomics in New Natural Products Discovery from Bacillus Species

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Abstract

The genus Bacillus has been a source of bioactive metabolites that could be used as lead compounds for drug discovery. However, natural product isolation demands too much time, resource, larger material, and efficient strategies of dereplication. In tackling these challenges, metabolomics can be used as a tool that facilitates the process of metabolites isolation and dereplication. As an emerging technology, metabolomics has a great and largely untapped potential in the fields of natural product discovery. Using metabolomics technologies, hundreds and thousands of metabolites can be identified and characterized in small biological or environmental samples. Summary of recent bioactive metabolites isolated from bacilli together with metabolomics techniques and its potential application in microbial natural products discovery is summarized in this chapter.

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Acknowledgments

The authors are thankful to the Bangladesh Academy of Sciences for funding this work under the BAS-USDA project to MTI. They are also thankful to the RMC of BSMRAU, University Grants Commission of Bangladesh, and Ministry of Science and Technology of Bangladesh for partial funding to this work.

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Authors and Affiliations

  1. Department of Biology, College of Natural and Computational Science, Ambo University, Ambo, Ethiopia

    Zerihun T. Dame

  2. Institute of Biotechnology and Genetic Engineering (IBGE), Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh

    Md Tofazzal Islam

Authors
  1. Zerihun T. Dame
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  2. Md Tofazzal Islam
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Editor information

Editors and Affiliations

  1. Institute of Biotechnology and Genetic Engineering (IBGE), Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh

    Md Tofazzal Islam

  2. West Virginia University, Morgantown, WV, USA

    M. Mahfuz Rahman

  3. Department of Microbiology, Assam University, Silchar, Assam, India

    Piyush Pandey

  4. Faculty of Life Sciences, Humboldt University of Berlin, Berlin, Germany

    Michael Henry Boehme

  5. Department of Applied Biosciences, Ghent University, Ghent, Belgium

    Geert Haesaert

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Dame, Z.T., Islam, M.T. (2019). Tapping the Potential of Metabolomics in New Natural Products Discovery from Bacillus Species. In: Islam, M., Rahman, M., Pandey, P., Boehme, M., Haesaert, G. (eds) Bacilli and Agrobiotechnology: Phytostimulation and Biocontrol. Bacilli in Climate Resilient Agriculture and Bioprospecting. Springer, Cham. https://doi.org/10.1007/978-3-030-15175-1_11

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