Skip to main content
SpringerLink
Log in

The Emerging Medical Landscape

  • Chapter
  • First Online:
The Biology of Senescence

Part of the book series: Practical Issues in Geriatrics ((PIG))

  • 519 Accesses

Abstract

The emerging clinical landscape is dominated by the overwhelming human responsibility and the rising incidence of non-transmissible chronic diseases including cancers, diabetes, CV, neurodegenerative (Alzheimer’s, Parkinson’s), respiratory and kidney diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 89.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    For general considerations, see [2,3,4]. As in many other countries, the situation of cancer in France is periodically evaluated by the “Institut du cancer”, INCa (see “La situation du cancer en France”. www.e-cancer.fr; see also Vernant JP. Recommandations pour le troisième plan cancer. Juillet 2013; on Internet); Jougla E. Indicateurs de mortalité “prématurée” et “évitable”. HCSP Avril 2013. Collection Documents; for more societal considerations see [5,6,7].

  2. 2.

    i.e. when Pasteur discovered bacteria and their central role, in. the mid XIXth century. Simultaneously, the discoveries of Claude Bernard, Gregor Mendel and Charles Darwin began to have medical applications [16]. See also Parascandola [17] for a historical discussion on the new concept of causation in epidemiology and its extension to every class of disease, transmissible or non transmissible.

  3. 3.

    For example, a new mechanism has recently been proposed in a mice model which questions the production of deoxycholic acid, ADC, in some gut Bacteria induced by the feeding regime. ADC itself can induce cancer through its pro-ageing cellular effects [25]. This is a prototype of cascade mechanisms which are the origin of several dysbioses.

References

  1. Brand S. Whole earth discipline. New York: Viking Penguin Publications; 2008. (a French version has been published in 2014 by Tristam ed Auch).

    Google Scholar 

  2. Aouba A, et al. L’évolution de la mortalité et des causes de décès entre 1990 et2009. Actualité et Dossier en Santé Publique. 2012;80:24–8.

    Google Scholar 

  3. Cambois E, et al. Ageing and health in France: an unexpected expansion of disability in mild-adulthood over recent years. Eur J Public Health Adv. 2012;23(4):1–7. https://doi.org/10.1093/eurpub/cks136.

    Article  Google Scholar 

  4. Puymirat E, et al. Association of changes in clinical characteristics and management with improvement in survival among patients with ST-elevation myocardial infarction. JAMA. 2012;308:998–1006.

    Article  CAS  Google Scholar 

  5. Grimaldi A, et al. Les maladies chroniques. Vers la 3e médecine. Paris: Odile Jacob; 2017.

    Google Scholar 

  6. Kontis V, et al. Future life expectancy in 35 industrialized countries: projections with a Bayesian model ensemble. Lancet. 2017;389(10076):1323–35.

    Article  Google Scholar 

  7. Toussaint JF, et al. Croissance et renoncements : vieillir à l’épreuve du temps. Esprit Juillet. 2010;7:60–74.

    Article  Google Scholar 

  8. Federau A. Pour une philosophie de l’Anthropocène. Paris: PUF Publication; 2017.

    Google Scholar 

  9. Hibbard KA, et al. The great acceleration. In: Costanza R, et al., editors. Sustainability or collapse? An integrated history and future of people on earth. Dalhem Worshop Report 96. Cambridge: MIT Press; 2017. p. 417–46.

    Google Scholar 

  10. Rockström J. A safe operating space for humanity. Nature. 2009;461:472–5.

    Article  Google Scholar 

  11. Steffen W, et al. The Anthropocene: are humans now overwhelming the great forces of nature? AMJBIO J Human Environ. 2007;36:614–21.

    Article  CAS  Google Scholar 

  12. Hsiang SM, et al. Civil conflicts are associated with the global climate. Nature. 2013;476:438–41.

    Article  Google Scholar 

  13. Swynghedauw B. L’homme malade de lui-même. Paris: Belin Editions; 2015.

    Google Scholar 

  14. Watts N, et al. The lancet countdown : tracking progress on health and climate change. Lancet. 2017;389:1151–64.

    Article  Google Scholar 

  15. MacMichael A, et al. Globalization, climate change, and human health. N Engl J Med. 2013;368:1335–432013.

    Article  Google Scholar 

  16. Swynghedauw B. Les racines dixneuviémistes de la révolution biologique contemporaine. Histoire Sc Med. 2006;40:141–50.

    Google Scholar 

  17. Parascandola M. The epidemiological transition and changing concepts of causation and causal inference. Rev Histoire Sc. 2011;64:243–62.

    Article  Google Scholar 

  18. GBDS, Global Burden of Disease 2016. Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the GBDS 2016. Lancet. 2016;390:1211–59.

    Google Scholar 

  19. GBDS, Global Burden of Disease 2016. DALYS and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYS) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the GBDS 2016. Lancet. 2016;390:1260–344.

    Google Scholar 

  20. Rocca WA, et al. Bilateral oophorectomy and accelerated ageing: cause or effect? J Gerontol A Biol Sci Med Sci. 2017;72:1213–7.

    Article  Google Scholar 

  21. Rochefort H. Endocrine disruptors (EDs) and hormone-deendent cancers: correlation or causal relationships? C R Biol. 2017;340:439–45.

    Article  Google Scholar 

  22. Yusuf S, et al. Global burden of cardiovascular diseases. Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies. Circulation. 2001;104:2855–64.

    Article  CAS  Google Scholar 

  23. Labonté R, et al. The growing impact of globalization for health and public health practice. Annu Rev Public Health. 2011;32:263–83.

    Article  Google Scholar 

  24. Bray F, et al. Global cancer transitions according to the human development index (2008-2030): a human population-based study. Lancet Oncol. 2012;13:790–801.

    Article  Google Scholar 

  25. Yoshimoto S, et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature. 2013;499:92–101.

    Article  Google Scholar 

  26. Berger MF, et al. The emerging clinical relevance of genomics in cancer medicine. Nat. Rev Clin Oncol. 2018;15:353–65.

    Article  CAS  Google Scholar 

  27. Alexandrov LB, et al. Signatures of mutational processes in human cancer. Nature. 2013;500:415–21.

    Article  CAS  Google Scholar 

  28. Kandoth C, et al. Mutational landscape and significance across 12 major cancer types. Nature. 2013;502:333–9.

    Article  CAS  Google Scholar 

  29. Lawrence MS, et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013;499:214–8.

    Article  CAS  Google Scholar 

  30. Burcelin R, et al. Immuno-microbiota cross and talk : the new paradigm of metabolic diseases. Semin Immunol. 2012;24:67–74.

    Article  CAS  Google Scholar 

  31. von Hertzen L, et al. Natural immunity. Biodiversity loss and inflammatory diseases are two global megatrends that might be related. EMBO Rep. 2011;12:1089–95.

    Article  Google Scholar 

  32. Pinheiro PS, et al. Cancer incidence in first generation US Hispanics: Cubans, Mexicans, PuertoRicans, and new Latinos. Cancer Epidemiol Biomark Prev. 2009;18:2162–9.

    Article  Google Scholar 

  33. Rouhani P, et al. Increasing rates of melanoma among nonwhites in Florida compared with the US. Arch Dermatol. 2010;146:741–6.

    Article  Google Scholar 

  34. Cutler DM, et al. Evidence for significant compression of morbidity in the elderly US population. Cambridge: Voir le site du NBER; 2013.

    Book  Google Scholar 

  35. Lozano R, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study. Lancet. 2012;380:2095–128.

    Article  Google Scholar 

  36. Alpérovitch A, et al. Do we really know the cause of death of the very old? Comparison between official mortality statistics and cohort study classification. Eur J Epidemiol. 2009;24:669–75.

    Article  Google Scholar 

  37. Finkel T, et al. The common biology of cancer and ageing. Nature. 2007;448:767–74.

    Article  CAS  Google Scholar 

  38. Cupit-Link MC, et al. Biology of premature ageing in survivors of cancer. ESMO Open. 2017;2:e000250.

    Article  Google Scholar 

  39. Peretti C. Personnes hospitalisées pour infarctus du myocarde en France: tendances 2002–2008. BEH. 2012;4:459–65.

    Google Scholar 

  40. Bounhoure JP. L’infarctus du myocarde au-delà de 75 ans. In: Les effets du vieillissement sur le système CV. Paris: Frison-Roche pub; 1986.

    Google Scholar 

  41. Plouin PF, et al. L’hypertension artérielle du sujet âgé. Bull Acad Natle Méd. 2006;190:793–806.

    Google Scholar 

  42. Danaei G, et al. National, regional, and global trends in systolic blood pressure since 1980: a systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5.4 million participants. Lancet. 2011;377:568–77.

    Article  Google Scholar 

  43. Komajda M, et al. The euro heart failure survey programme. A survey on the quality of care among patients with heart failure in Europe. Part II: treatment. Eur Heart J. 2003;24:464–74.

    Article  CAS  Google Scholar 

  44. Baldi I, et al. Neurodegenerative diseases and exposure in the elderly. Am J Epidemiol. 2003;157:409–14.

    Article  Google Scholar 

  45. Beach TG, et al. Patterns of gliosis in Alzheimer’s disease and ageing cerebrum. Glia. 1989;2:420–36.

    Article  CAS  Google Scholar 

  46. Collier TJ, et al. Ageing as a primary risk factor for Parkinson’s disease! Evidence from studies of non-human primates. Nat Rev Neurosci. 2011;12:359–66.

    Article  CAS  Google Scholar 

  47. Godet O, et al. Association of white-matter lesions with brain atrophy markers : the three-city Dijon MRI study. Cerebrovasc Dis. 2009;28:177–84.

    Article  Google Scholar 

  48. Jacqmin-Gadda H, et al. 20-year prevalence projections for dementia and impact of preventive policy about risk factors. Eur J Epidemiol. 2013;28:493–502.

    Article  Google Scholar 

  49. Ménard J. Rapport Pour le malade et ses proches, chercher, soigner et prendre soin. Commission sur l’Alzheimer Novembre 2007.

    Google Scholar 

  50. Weller RO, et al. Cerebrovascular disease is a major factor in the failure of elimination of Abeta from the ageing human brain. AA N Y Acad Sci. 2002;977:162–8.

    Article  CAS  Google Scholar 

  51. Chilosi M, et al. The pathogenesis of COPD and IPF : distinct horns for the same devil? Respir Res. 2012;13:3.

    Article  Google Scholar 

  52. Cottin V, et al. Pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema syndrome. Eur Respir J. 2010;35:105–11.

    Article  CAS  Google Scholar 

  53. Ponçot-Mongars R, et al. Syndrome emphysème-fibrose pulmonaire combinés. Revue Maladies Respiratoires. 2013;30:222–6.

    Article  Google Scholar 

  54. Bartling B. Cellular senescence in normal and premature lung ageing. Z Gerontol Geriat. 2013;46:613–22.

    Article  CAS  Google Scholar 

  55. Belmin J, et col. ed. Gériatrie. Elsevier/Masson; 2009. 835 pp.

    Google Scholar 

  56. Schmitt R, et al. Mechanisms of renal ageing. Kidney Int. 2017;92(3):569–79. https://doi.org/10.1916/j.kint.2017.02.036.

    Article  CAS  PubMed  Google Scholar 

  57. Sturmlechner I, et al. Cellular senescence in renal ageing and disease. Nat Rev Nephrol. 2017;13:77–89.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. French Institute of Health and Medical Research, Paris, France

    Bernard Swynghedauw

Authors
  1. Bernard Swynghedauw
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Swynghedauw, B. (2019). The Emerging Medical Landscape. In: The Biology of Senescence. Practical Issues in Geriatrics. Springer, Cham. https://doi.org/10.1007/978-3-030-15111-9_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-15111-9_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-15110-2

  • Online ISBN: 978-3-030-15111-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation